Pro-Hemostatic Therapies Flashcards Preview

Common Surgery Meds > Pro-Hemostatic Therapies > Flashcards

Flashcards in Pro-Hemostatic Therapies Deck (12):
1

Recombinant activated Factor VIIa (NovoSeven RT)

Route

Indications

Route: IV

Indications: bleeding and perioperative management of congenital factor VII deficiency
acquired hemophilia
congenital hemophilia

massively bleeding trauma pts (improve survivability)

Off label: warfarin related intercerebal hemorrhage

2

Recombinant activated Factor VIIa (NovoSeven RT) MOA

Recombinant factor VIIa, vit K-dependent glycoprotein, promotes hemostasis by activating extrinsic

3

Recombinant activated Factor VIIa (NovoSeven RT)

Adverse effects

Contraindications

BBW- arterial and venous thrombosis
HTN, bradycardia, CVD, fever, vomiting, renal impairment, hypersensistivity rxn, hemorrhage, hemarthrosis

Contraind: NONE

4

What should pt be screened for before and after use of Recombinant activated Factor VIIa (NovoSeven RT)?

PT and factor VII coag activity

5

Transexamic acid (Lysteda)
route
indications

route: IV, PO

indications: heavy menstrual bleeding, tooth extraction in hemophilia
blood loss prevention and reduction in high blood loss surgeries, trauma-associated hemorrhage, traumatic hypehma

6

Transexamic acid (Lysteda) MOA

forms reversible complex that displaces plasminogen from fibrin resulting in inhibition of fibrinolysis and also inhibits proteolytic activity of plasmin

7

Transexamic acid (Lysteda)
Adverse Effects
Contraind

Adverse Effects: HA, abdominal pain, skeletal muscle pain, nasal sx, fatigue, anemia, CNS depression, retinal venous and arterial occlusions, VTE, eizures

Contraind: hypersensitivity, acquired defective color vision, active intravascular clotting, subarachnoid hemorrhage

8

When should Transexamic acid (Lysteda) be used in surgery setting to be mot effective for uncontrolled bleeding?

within 3 hours of injury onset

9

Demopressin (DDAVP)
Route
Indications

Route: IV, intranasal

Indications: diabetes insipidus, nocturia, primary nostural enuresis, hemophilia A, von willebran disease, uremic bleeding, prevention of surgical bleeding in pts with uremia
Off-label: intracranial hemorrhage associated with antiplatelet agents (ASA, Plavix)

10

Demopressin (DDAVP) MOA

Synthetic analogue of ADH arginine vasopressin. IN dose dependent manner, demopressin increases cAMP in renal rubular cells which ↑ water permeability resulting in ↓ urine volume and ↑ urine osmolality

↑ plama levels of vWF, factor VII and t-PA contributing to shortened activate d aPTT and bleeding time

11

Demopressin (DDAVP)
Adverse reactions
Contraind

Adverse reactions: hyponatremia, HA, dizziness, N/V, abdominal pain, rhinitis, nasal congestion, epistaxis, thrombotic events (rare)

Contraind: hypersensitivity to agent, hyponatremia

12

What pregnancy category is Demopressin (DDAVP)?

Cat B