Prolactin Flashcards

1
Q

inhibitor of PRL release

A

dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

effects of excess PRL

A

inhibition of reproduction in males and females

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

promoters of PRL

A

estrogen, breast suckling, super high TRH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

clinical features of hyperprolactinemia

A

women: amenorrhea and galactorrhea in fertile
men: loss of libido, ED

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

common etiologies for hyperprolactinemia

A

pituitary adenoma
pharmacological: Dopamine receptor antags
primary hypothyroidism: XS TRH stimulates PRL secretion
PCOS: polycystic ovaries, idiopathic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

bromocriptine definition

A

dopamine agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

bromocriptine adverse effects

A

GI problems, orthostasis and syncope, decreased efficacy of anti-psychotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

bromocriptine dosage

A

adverse effects mitigated if the therapy is titrated slowly to peak

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

bromocriptine indications

A

hyper-PRL, acromegaly, Parkinson’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

bromocriptine eval.

A

plasma PRL to normal, clinical symptom management in hyper–PRL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

cabergoline definition & dosage

A

higher affinity, longer half life than bromocriptine. more expensive but few doses per week

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

cabergoline adverse effects

A

in high doses associated with cardiac valvular disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly