Prolactin Flashcards
inhibitor of PRL release
dopamine
effects of excess PRL
inhibition of reproduction in males and females
promoters of PRL
estrogen, breast suckling, super high TRH
clinical features of hyperprolactinemia
women: amenorrhea and galactorrhea in fertile
men: loss of libido, ED
common etiologies for hyperprolactinemia
pituitary adenoma
pharmacological: Dopamine receptor antags
primary hypothyroidism: XS TRH stimulates PRL secretion
PCOS: polycystic ovaries, idiopathic
bromocriptine definition
dopamine agonist
bromocriptine adverse effects
GI problems, orthostasis and syncope, decreased efficacy of anti-psychotics
bromocriptine dosage
adverse effects mitigated if the therapy is titrated slowly to peak
bromocriptine indications
hyper-PRL, acromegaly, Parkinson’s
bromocriptine eval.
plasma PRL to normal, clinical symptom management in hyper–PRL
cabergoline definition & dosage
higher affinity, longer half life than bromocriptine. more expensive but few doses per week
cabergoline adverse effects
in high doses associated with cardiac valvular disease
