Prolactin

Question 1

inhibitor of PRL release

Answer 1

dopamine

Question 2

effects of excess PRL

Answer 2

inhibition of reproduction in males and females

Question 3

promoters of PRL

Answer 3

estrogen, breast suckling, super high TRH

Question 4

clinical features of hyperprolactinemia

Answer 4

women: amenorrhea and galactorrhea in fertile
men: loss of libido, ED

Question 5

common etiologies for hyperprolactinemia

Answer 5

pituitary adenoma
pharmacological: Dopamine receptor antags
primary hypothyroidism: XS TRH stimulates PRL secretion
PCOS: polycystic ovaries, idiopathic

Question 6

bromocriptine definition

Answer 6

dopamine agonist

Question 7

bromocriptine adverse effects

Answer 7

GI problems, orthostasis and syncope, decreased efficacy of anti-psychotics

Question 8

bromocriptine dosage

Answer 8

adverse effects mitigated if the therapy is titrated slowly to peak

Question 9

bromocriptine indications

Answer 9

hyper-PRL, acromegaly, Parkinson’s

Question 10

bromocriptine eval.

Answer 10

plasma PRL to normal, clinical symptom management in hyper–PRL

Question 11

cabergoline definition & dosage

Answer 11

higher affinity, longer half life than bromocriptine. more expensive but few doses per week

Question 12

cabergoline adverse effects

Answer 12

in high doses associated with cardiac valvular disease