PROSTATE CONDITIONS INCLUDING MEDICATIONS

Question 2

describe the hypothalamic pituitary testicular axis

Answer 2

hypothalamus releases GNRH
ant pit releases FSH AND LH
FSH BINDS TO SERTOLI CELLS (SUSTENTACULAR CELLS) TO NURTURE CELLS
LH BINDS TO LEYDIG CELLS RESPONSIBLE FOR PRODUCTION OF sperm CELLS

Question 3

WHAT IS THE ROLE OF SPERMATOGENIC CELLS

Answer 3

MAKE SPERM CELLS

Question 4

WHAT IS THE ROLE OF SUSTENTACULAR (SERTOLI CELLS)

Answer 4

NOURISH DEVELOPING SPERM

Question 5

WHAT IS THE ROLE OF INTERSITITIAL ENDOCHRINE CELLS (LEYDIG CELLS)

Answer 5

PRODUCE ANDROGENS > TESTOSTERONE

Question 6

WHAT IS THE ROLE OF MYOID CELLS

Answer 6

CONTRACT RHYTHMICALLY TO SQUEEZE SPERM AND FLUIDS OUT ON THE SEMINEFEROUS TUBES

Question 7

WHAT IS THE LOCATION OF THE PROSTATE

Answer 7

ENCIRCLES THE PROSTATIC URETHRA

Question 8

THE PROSTATE IS MADE UP OF WHAT GLANDS

Answer 8

TUBULOALVEOLAR

Question 9

WHAT ARE THE TUBULOALVEOLAR CELLS EMBEDDED IN

Answer 9

STROMA

Question 10

THE SUPPORTS OF THE STROMA OF THE PROSTATE GLAND ARE

Answer 10

FIBROUS CT
SMOOTH MM FIBRES
PROSTATIC INTERSTIIAL CELLS

Question 11

THE SMOOTH MUSCLE FIBRES OF THE STOMA OF TEH PROSTATE GLAND POSESS WHAT RECEPTORS

Answer 11

ALPHA 1 ANDRENERGIS RECEPTORS

Question 12

WHAT DO ALPHA 1 ANDRONERGIC RECEPTORS RESPOND TO AND WHAT DOES IT CAUSE

Answer 12

SYMPATHETIC NS (NOREADRENALINE AND ADRENALINE)

CAUSING PROSTATIC CONTRACTION

Question 13

TAMSULOSIN IS WHAT KIND OF MEDICATION

Answer 13

ANDRONERGIC ANTAGONIST

Question 14

what region of the sprostate is most commonly affected by benign prostatic hyperplaysia

Answer 14

transition zone

Question 15

what causes benign prostatic hyperplaysia

Answer 15

DHT dihydrotestosterone

Question 16

what region of the prostate is most commonly affected by prostate cancer

Answer 16

peripheral zone

Question 17

what enzyme converts testosterone to DHT

Answer 17

5a reductatse

Question 18

where does DHT bond and what does it do

Answer 18

androgen receptors in the prostate which stimulates production of growth factors

Question 19

what are the two types of clinical features of benign prostatic hyperplaysia

Answer 19

obstructuve issues - obstruction to urinary flow
irritative issues - retention of urine

Question 20

where are 5a reductase receptors located

Answer 20

prostate and hair follicles

Question 21

what drug unhibits 5 alpha reductase

Answer 21

finasteride

Question 22

how does finasteride work

Answer 22

inhibits the 5 alpha reducatse receptors and in turn decreased the amount of Dihydrotestosterone in the prostate, causing less growth of the prostate.

can also take to prevent male pattern baldness

Question 23

what is the most common cancer of the prostate

Answer 23

adenocarcinoma

Question 24

what is the aetiology of prostate cancer

Answer 24

unknown, but seems to be a complex interplay between age genetics, hormones, and environmental influences

Question 25

if a prostate tumour arises in the periphery of the gland what is there a risk for

Answer 25

metastisis to the spine spread through blood and lymphatics