Prostatic Hyperplasia Flashcards Preview

Medicine Phase 2a GU > Prostatic Hyperplasia > Flashcards

Flashcards in Prostatic Hyperplasia Deck (10):
1

Define

Increase in the size of the prostatic gland without malignancy

2

Pathophysiology

Glandular epithelial cells and stroll cells undergo hyperplasia
Usually the MEDIAN LOBE is affected

3

Aetiology

Not fully known.
Assumed relationship to androgens, possibly promoting cell proliferation in the prostate.

4

Epidemiology

Affects QOL of:
40% of men in 50s
90% of men in 90s

5

Clinical presentation

Frequent urination
Incomplete emptying
Intermittent stream
Weak stream
Urgency
Nocturia
Straining (I-PSS grading)

6

Diagnosis

History
Ultrasound
DRE

7

Treatment

Watchful waiting.
Alpha blockers (doxazosin) to those with severe voiding problems.
5-alpha reductase inhibitor (finasteride)
Surgery: Large prostate/failure to respond; transurethral resection of the prostate.

8

Complications

Recurrent UTI. Bladder calculi.

9

Treatment - example of alpha blocker

Doxazosin or Tamsulosin

10

Treatment - example of 5-alpha reductase inhibitor

Finasteride