Protein Function and Regulation

Question 1

list the major regulatory mechanisms that control enzyme activity (plus examples)

Answer 1

D

Question 2

discuss the allosteric properties of a key regulatory enzyme

Answer 2

A

Question 3

discuss the concept of enzyme cascades and the use of protein kinases and phosphatases to regulate activity

Answer 3

D

Question 4

define the term zymogen

Answer 4

H

Question 5

explain how activation of the clotting cascade leads to the formation of fibrin

Answer 5

D

Question 6

discuss the mechanisms that are involved in the regulation of clot formation and breakdown

Answer 6

S

Question 7

explain the physiological roles of myoglobin and haemoglobin

Answer 7

R

Question 8

contrast the oxygen-binding properties of myoglobin and haemoglobin and explain why haemoglobin is most suited to its role as an oxygen transporter

Answer 8

H

Question 9

describe the major structural differences between oxygenated and deoxygenated haemoglobin and the molecular basis of cooperativity

Answer 9

O

Question 10

describe the effects of CO2, H+, 2,3-bisphosphoglycerate and carbon monoxide on the binding of oxygen by haemoglobin, and the physiological significance of these effects

Answer 10

F

Question 11

appreciate that mutations in globin genes can give rise to diseases such as sickle cell anaemia

Answer 11

I

Question 12

outline of the key features needed for protein secretion

Answer 12

I

Question 13

describe the differences between constitutive and regulated secretion

Answer 13

I

Question 14

outline of the structure of collagen

Answer 14

I

Question 15

outline of the processing of collagen

Answer 15

O