Protein Structure, Ligand Binding And Conformational Change- Reversible Binding And The Control Of Conformation

Question 1

What can the addition or removal of phosphate cause?

Answer 1

Reversible conformational change in proteins

Question 2

What is a common form of post-translational modification?

Answer 2

The addition and removal of phosphate

Question 3

What does the protein kinase do?

Answer 3

It catalyses the transfer of a phosphate group to other proteins

Question 4

Where is the terminal phosphate of ATP is transferred to?

Answer 4

specific R groups

Question 5

What does the protein phosphatases do?

Answer 5

It catalyses the removal of a phosphate group from other proteins

Question 6

What does phosphorylation bring about?

Answer 6

Conformational changes which can affect a protein’s activity

Question 7

What is regulated by phosphorylation of a protein?

Answer 7

The activity of many cellular proteins such as enzymes and receptors

Question 8

Are some proteins activated by phosphorylation?

Answer 8

Yes but other are inhibited

Question 9

Does adding a phosphate group add a positive or negative charge

Answer 9

A negative charge

Question 10

Can ionic interactions in the unphosphorylated protein be disrupted?

Answer 10

Yes and new ones can be created