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YEAR 1: MCD - Metabolism > Proteins > Flashcards

Flashcards in Proteins Deck (10)
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1

Which form are all amino acids in ?

L optical isomer

2

Hydrophobic

Glycine
Alanine
Proline
Valine
Leucine
Isoleucine
Tryptophan
Phenylalanine

3

Hydrophilic

Serine
Theory one
Tyrosine
Asparagine
Glutamine
Cysteine

4

Positively charged side chain

Arginine
Lysine
Histidine is protonated (+) under pH 6

5

Negatively charged

Glutamate
Aspartate

6

Why can proteins not tolerate a great change in pH?

Ionisation state of amino acids is essential for function.
Changes in pH = change in ionisation state = change in property
Amino acids can take up and release protons = gives them capacity to resist some changes in pH

7

When do disulphide bridges form?

Cytosine chains oxidise
Covalent bond between 2 amino acids

8

Why does proline cause a kink in the peptide chain?

When proline is added = loss of NH group
Side chain can’t form hydrogen bonds with C=O of another part of chain
KINK

9

What is a parallel beta strand?

Beta sheets run parallel to each other
Beta sheets run anti parallel = antiparallel beta sheet

10

How does warfarin work?

Glutamate needs to be converted to gamma-carboxylglutamate
This is needed for calcium binding
Warfarin inhibits this reaction