Proton Pump Inhibitors

Question 1

Proton Pump Inhibitors Drug Names

Answer 1

Omeprazole 
Esomeprazole 
Lansoprazole 
Pantoprazole 
Rabeprazole

Question 2

Proton Pump Inhibitors Therapeutic Actions

Answer 2

• Act at specific secretory surface receptors to prevent the final step of acid production and thereby decrease the level of acid in the stomach

Question 3

Proton Pump Inhibitors Indications

Answer 3

• Short-term treatment of active duodenal ulcers, GERD, erosive esophagitis, and benign active gastric disease
• Long-term treatment of pathological hypersecretory conditions

Question 4

Proton Pump Inhibitors Contraindications and Cautions

Answer 4

Contraindications:
• Known allergy

Caution:
• Pregnancy or lactation

Question 5

Proton Pump Inhibitors DDI

Answer 5

DDI: 
•	Benzodiazepines, phenytoin, warfarin
-	Increase toxicity of these meds
•	Ketoconazole, theophylline
-	Decreased levels of these medications
•	Sucralfate
-	PPIs not absorbed well
•	Clopidogrel
-	Increase CV effects

Question 6

Proton Pump Inhibitors Adverse Effects

Answer 6

• CNS effects: Dizziness, headache, asthenia, vertigo, insomnia, apathy
• GI Effects: Diarrhea, abdominal pain, and tongue atrophy
• Upper respiratory tract symptoms: Cough, stuff nose, hoarseness, and epistaxis

Question 7

Proton Pump Inhibitors:

Assessment

Answer 7

Assess:
Hx: Allergy, lactation and pregnancy
Physical: vital signs, Neurological status, orientation, affect, reflexes, abdominal, respiratory status (baseline)

Question 8

Proton Pump Inhibitors:

Diagnosis

Answer 8

Dx:

• Diarrhea
• Risk for constipation
• Imbalanced nutrition: less than body requirements
• Disturbed sensory perception (kinesthetic, auditory)
• Risk for injury
• Deficient knowledge

Question 9

Proton Pump Inhibitors;

Implementation

Answer 9

Implementation:
• Administer drug before meals
• Provide appropriate safety and comfort measures
• Monitor the patient for diarrhea or constipation
• Monitor the patient’s nutritional status
• Provide thorough patient teaching

Question 10

Proton Pump Inhibitors:

Evaluation

Answer 10

Eval:
Response to the drug 
Adverse effects
 Effectiveness of comfort measures
Compliance with regimen
Effectiveness of teaching plan