Prudent exam, from ppt Flashcards

(79 cards)

1
Q

Susceptibility in P. multocida (Cattle)
Tulathromycin:
Gamithromycin:
Tilmicosin:

A

Tulathromycin: 95%
Gamithromycin: 95%
Tilmicosin: 80%

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2
Q
Lung:Plasma 
Tilmicosin:
Tulathromycin:
Gamithromycin:
Tildipirosin:
A

Tilmicosin: 30-60x
Tulathromycin: 50-180x
Gamithromycin: 480x
Tildipirosin: X

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3
Q

Which mode of action drug should be given IV?

A

Concentration dependent bactericidal agents

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4
Q

Which mode of action drug should be given IM, SC

A

Time dependent bactericidal

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5
Q

Which drugs have bad distribution?

A

Penicillin, cephalosporin, aminoglycoside

Will not penetrate the lungs

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6
Q

Which AB can be used for respiratory diseases in ruminants (M. bovis)

A
Tulathromycin
Gamithromycin
Tildipirosin
Florfenicol
Fluoroquinolones
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7
Q

Interdigital dermatitis treatment options

A

Zinc/copper sulphate + cationic degergent
Tetracyclines (cattle less susceptible, overuse)
NSAIDs

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8
Q

Which AB can be used for F. necrophorum and anaerobic (Ruminants)

A
Amoxicillin
Amoxicillin clavulanic acid
Tetracycline
Lincomycin
Tylosine
Tulathromycin
Ceftiofur/Cefquinome
Florfenicol
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9
Q

Mild case calf diarrhoea, what AB can be used (PO)

A

Amoxicillin (Main one)
Fluoroquinolones
Aminoglycoside
Colistin

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10
Q

Severe case calf diarrhoea, what AB can be used (IV)

A

Ceftiofur (High dose)
Amoxicillin (Sheep), Amoxicillin clavulanic acid
Fluoroquinolones (Enro and Marbo)

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11
Q

Mastitis, when is the cow at risk?

A

Involution: increased susceptibility to Gr+
Transition: increased susceptibility to Gr-

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12
Q

Systemic treatment of clinical mastitis

A

Fluoroquinolones IV (Marbo, Enro)
Tetracyclines IV
Pot. SA IV

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13
Q

Intramammary treatment of clinical mastitis (staph, Strep. E.coli)

A
Ampicillin + cloxacillin
Cefalexin, cephapirin
Amoxicillin clavulanic acid
Cefoperazone
Cefquinome
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14
Q

Which drug groups are off-label in Poultry

A

Gen 3 & 4 Cephalosporins
Gen 1 & 2 Cephalosporins
Amoxicillin clavulanic acid

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15
Q

Which drugs have synergistic effect?

A

Sulphonamide + Trimethoprim
Lincomycin + Spectinomycin
Amoxicillin + Gentamycin

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16
Q

Which narrow spectrum penicillin has good oral bioavailability?

A

Phenoxymethylpenicillin

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17
Q

What can we use narrow spectrum penicillins for?

A

Swine erysipelas
Streptococcosis
Fowl cholera

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18
Q

If going off label, what is the WP

A

1,5 times as long WP as the longest for cattle

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19
Q

What can we use broad spectrum penicillins for?

A
Clostridium
Erysipelas
FIRST CHOICE: Fowl cholera
O. rhinotracheale
Enterococcus
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20
Q

What is the WP for Amoxicillin in poultry?

A

1-2 weeks

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21
Q

Spectinomycin, which bacteria is/are sensitive?

A

Mycoplasma is sensitive

Generally: quick resistance is developed

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22
Q

What can we use tetracyclines for?

A

Fowl cholera
O. rhinotracheale
Mycoplasmosis
Bordetella avium

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23
Q

What can we use Macrolides for?

A
C. perfringens
E. rhusiopathiae
Staphylococcus spp.
Mycoplasma gallisepticum and synoviae
O. rhinotracheale
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24
Q

Which bacteria has almost total resistance against Macrolides?

A

Pasteurella multocida

E. coli

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25
What can we use Lincosamides for?
Mycoplasmosis C. perfringens Staphylococcosis
26
What can we use Pleuromutilins for?
Mycoplasmosis (Tiamulin) | O. rhinotracheale
27
Pleuromutilins are incompatible with:
Ionophores
28
Can we use Chloramphenicol in food producing animals?
NO!
29
What can we use Florfeniol for?
Mycoplasmosis Respiratory infections (Ornithobacterium) Fowl cholera E. coli
30
Which side effects can you get using Pot. SA?
Bone marrow suppression | Vitamin K deficiency
31
What can we use Pot. SA for?
P. multocida B. avium Not effecting against Mycoplasma!
32
What can we use Fluoroquinolones for?
Only if nothing else E. coli, Mycoplasma spp (CRD) Fowl cholera A. paragallinarum B. avium
33
Which bacteria is/are frequently resistance against Fluoroquinolones?
O. rhinotracheale | E. coli (More resistance in poultry than in swine)
34
``` E. coli sensitivity test in poultry! Amoxicillin: Amoxicillin clavulanic acid: Aminoglycosides: Colistin: Tetracycline: Florfenicol: Pot. SA: Fluoroquinolone: ```
``` Amoxicillin: 40-70% Amoxicillin clavulanic acid: 1-10% Aminoglycosides: 20-30% Colistin: 5% Tetracycline: 40-90% Florfenicol: <10% Pot. SA: 25-40% Fluoroquinolone: 60-80% ```
35
Which AB can be used against P. multocida (Fowl cholera)
Amoxicillin Florfenicol Doxycycline Pot. SA (Enrofloxacin, tylvalosin)
36
Which AB can be used against O. rhinotracheale
Amoxicilline Doxycycline Florfenicol (Tylosin, tilmicosine, tylvalosine)
37
Which AB cannot be used against O. rhinotracheale
Pot. SA | Fluoroquinolone
38
Which AB can be used against Clostridium perfringens
Phenoxymethylpenicillin | Amoxicillin, tylosin, lincomycin
39
Which AB can be used against diarrhoea (E. coli) in piglets? (usually a peak right after weaning)
``` Gentamycin Amoxicillin clavulanic acid Florfenicol Ceftiofur Cefquinome Enrofloxacin Colistin ```
40
Which AB can be used against Proliferative enteritis (Lawsonia intracellularis)
``` Tylosin Lincomycin Tiamulin Tylvalosin Valnemulin ```
41
Which AB can be used against Dysentery (B. hyodysenteriae)
Lincomycin Tiamulin Tylvalosin Valnemulin
42
Which AB can be used against polyserositis (Streptococcus suis, Haemphilus parasuis and Mycoplasma hyorhinis)
Florfenicol (is the best choice, works on all three) | Doxycycline, Enrofloxacin
43
Which AB can be used against Mycoplasma hyopneumoniae
Tylvalosin Tulathromycin Tiamulin Valnemulin (Doxycycline, lincomycin, Linco-specin)
44
Which AB can be used against Actinobacillus pleuropneumoniae
Ceftiofur Cefquinome Florfenicol Enrofloxacin, Marbofloxacin (Doxycycline, Tilmicosin, Tiamulin, Tulathromycin)
45
Which AB can be used against Staphylococcus hyicus
Amoxicillin clavulanic acid (Amoxicillin alone will not work) Tylosin Lincomycin Pot. SA
46
Which AB can be used against Erysipelas
Amoxicillin | Penicillin
47
Which AB can be used against Pyoderma (S. pseudointermedius)
Oxacillin meticillin Cephalosporins Amoxicillin clavulanic acid NB! MRSP/MRSA
48
Which AB can be used against Pyoderma (E. coli, P. aeruginosa) Shampoo
Chlorhexidine | If deep: Benzoyl perixide
49
Which AB can be used against Pyoderma local AB
Aminoglycosides (Neomycin, gentamycin) | Macrolides (Erythromycin, Azithromycin)
50
Which AB can be used against deep Pyoderma systemic AB
1st line: Lactamase stable beta-lactams & Lincosamides 2nd line: Fluoroquinolones 3rd line: Macrolides
51
1st line against deep pyoderma:
``` Cephalosporins: Cefalexin Amoxicillin clavulanic acid Cefovecin (rather 2nd line) Lincosamides (75-80% sensitivity) Pot. SA ```
52
2nd line against deep pyoderma
``` Fluoroquinolones: Enro, marbo, cipro, prado Local: Mupriocin and Fusidic acid Rifampicin (Combination!) Amizacin Florfenicol ```
53
3rd line against deep pyoderma
Macrolides (Azithromyxin, clarithromycin) Vancomycin Teicoplanin
54
Duration for pyoderma
AB should be given at least 3-4 weeks
55
Duration for deep pyoderma
4-8 weeks
56
Which AB can be used against local staphylococcus otitis
``` Gentamycin Polymyxin B Orbifloxacin Marbofloxacin Florfenicol ```
57
Which AB can be used against pseudomonas otitis
Chlorhexidine Local: Gentamycin, tobramycin, polymyxin B, marbofloxacin Systemic: GC, Ciprofloxacin, marbofloxacin, enrofloxacin
58
Which AB can be used against Malassezia otitis
Local: Chlorhexidine, thiabendazole, miconazone, clotrimazole, posaconazole, terbinafine Systemic: Ketoconazole, itraconazole, terbinafine
59
Which AB to use against septic mastitis
Amoxicillin clavulanic acid + enrofloxacin
60
Which AB to use against non-septic mastitis
Gr+: Clindamycin, macrolides | Gr-: Fluoroquinolones
61
Which AB to use against pharyngitis, tonsillitis (Streptococcus spp.)
Penicillin Acute --> chronic: Penicillinm Cepahlosporin (1st gen), macrolides
62
Which AB to use against rhinitis
``` Acute: self healing Chronic: 4 weeks AB Doxycycline Azithromycin, clarithromycin Pot. SA ```
63
Which AB to use against Feline rhinotracheitis
Doxycycline Amoxicillin +/- clavulanic acid Azithromycin, clarithromycin
64
Which AB to use against bronchitis, pneumonia (life threatening)
Amoxicillin clavulanic acid IV BID Cephalosporins (Cefuroxime, ceftazidime, ceftriaxone) Aminoglycosides (gentamycinm, tobramycin, amikacin) Fluoroquinolones (Enro, Marbo)
65
Which AB to use against bronchitis, pneumonia (not life threatening)
Tetracycline Macrolides Pot. SA
66
Which AB to use against Kennel cough
Doxycycline --> antiinflammatory Pot. SA Macrolides 2. Fluoroquinolones 3. Amoxicillin clavulanic acid
67
Which AB to use against aspiration pneumonia
Broad spectrum beta-lactam + enrofloxacin (Aminoglycoside) + metronidazole GC is contraindicated!
68
Which AB to use against pyothorax
Broad spectrum beta-lactam + fluoroquinolone (Aminoglycoside) + metronidazole
69
Which AB to use against gingivitis, periodontitis
Amoxicillin clavulanic acid Metronidazole + spiramycin Clindamycin Cefovecin
70
Which AB to use against life threatening bacterial enteritis (Campylobacter)
Azithromycin Clarithromycin Clindamycin
71
Which AB to use against life threatening bacterial enteritis (E. coli)
Fluoroquinolones
72
Which AB to use against Antibiotic responsive diarrhoea
Tylosin Metronidazole Oxytetracycline
73
Which AB to use against chronic colitis
Metronidazole Tylosin Sulfasalazine Masalazine
74
Which AB to use against Parvovirosis
IV Amoxicillin clavulanic acid | Fluoroquinolone/aminoglycoside
75
Which AB to use against UTI (E. coli)
Amoxicillin clavulanic acid 2nd & 3rd gen Cephalosporins: Cepalexin, Cefuroxime, Cefovecin (CIA) Pot. SA Fluoroquinolones (Enro, Marbo)
76
Which AB to use against prostatitis
Fluoroquinolones Pot. SA Phenicols
77
Which AB to use against cystitis
1st line: Amoxicillin, Amoxicillin clavulanic acid, cefalexin, Pot. SA 2nd line: Cefovecin, fluoroquinolones, nitrofurantoin/fosfomycin/amikazin
78
Which AB to use against pyelonephritis
Fluoroquinolones (high dose!) | Ceftriaxon - Aminoglycoside (Gentamycinm tobramycin, amikacin)
79
When should we avoid the usage of the antibiotic
``` Pharyngitis, tonsilitis? Acute rhinitis CIRCD (first 10 days) Mild gingivitis, periodontitis Acute enteritis (if good general condition) Cat FLUTD ```