PSA

Question 1

What are the effects of enzyme inducers on Cytochrome P450

Answer 1

An enzyme inducer will increase P450 enzyme activity

Question 2

What effect will increasing cytochrome P450 have on drug concentrations

Answer 2

Increasing Cytochrome P450 will decrease drug concentrations as it will increase the rate which the drug is broken down.

Question 3

What is 1 FTU? (fingertip units)

Answer 3

1 FTU is the amount of medication needed to squeeze a line from the tip of an adult finger to the first crease of the finger, and provides enough to treat one side of both hands.

Question 4

How long before surgery do you stop Combined oral contraceptive pill (COCP) and hormone replacement therapy (HRT)?

Answer 4

4 weeks before surgery

Question 5

How long before surgery do you stop Lithium?

Answer 5

Day before

Question 6

Potassium-sparing diuretics and angiotensin-converting enzyme (ACE) -inhibitors

Question 7

Which drugs should be stopped at least a week before surgery? (4)

Answer 7

Hormonal therapy (HRT) - 4 weeks
MAO-B inhibitors (selegiline) - 2 weeks
Antiplatelets (aspirin) - 7 days
SSRIs/SNRIs - 1 week

Question 8

Which drugs should be stopped at least 5 days before surgery? (2)

Answer 8

Anticoagulants (warfarin)
NSAIDs

Question 9

Which drugs should be stopped at least 3 days before surgery? (1)

Answer 9

DOACs

Question 10

which drugs should be stopped the day before surgery? (4)

Answer 10

Diuretics
ACE1/ARB
Metformin
SGLT2i (gliflozins)

Question 11

Drugs to stop the day of surgery?