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MOAYAD - Dermatology Topics > Psoriasis > Flashcards

Psoriasis Flashcards

1
Q

what is typical location of psoriasis ?

A
  • Elbow, knee, gluteal cleft and scalp.
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2
Q

Types of psoriasis ?

A
  • Type I disease (HLA-Cw6+) ( more severe ) have an earlier onset, more widespread disease and frequent recurrences. and it involves genital region. usually after infections.
  • Type II psoriasis.
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3
Q

what is the characteristic lesion for psoriasis?

A
  • Plaques, papule.
  • The characteristic lesion is a sharply demarcated erythematous plaque with scale; the plaques may be localized or widespread in distribution.
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4
Q

Which features are estimated in PASI score ?

A

Erythema, induration and scale.

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5
Q

What is the most common cause of erythroderma is adults ?

A

Psoriasis.

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6
Q

When can we use systemic treatment PSORIASIS AREA AND SEVERITY INDEX (PASI)?

A
  • over 10.

- max. 72

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7
Q

What is the least common classification of psoriatic arthritis?

A

Arthritis mutilans

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8
Q

DOC in the treatment of pustular psoriasis ?

A

Acitretin.

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9
Q

SUBTYPES OF PSORIASIS ?

A
  • psoriasis guttata
  • psoriatic erythrodermia
  • palmoplantar psoriasis.
  • pustular psoriasis
  • pustulosis of the hand and soles.
  • psoriatic arthritis.
  • inverse psoriasis.
  • nail psoriasis.
  • scalp psoriasis.
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10
Q

KOEBNER PHENOMENON is ?

A

After skin injury typical psoriatic leasions are seen in affected skin.

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11
Q

Immunopathogenesis of psoriasis ?

A
  • prominent involvement of helper T-cell subsets (Th1 and Th17) and their secreted cytokines: TNF - alpha, IL12 , IL 23.
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12
Q

Most common presentation of psoriatic arthritis ?

A
  • Mono and asymmetric oligoarthritis. (involvement of PIP and DIP) “ sausage digit “
  • In contrast to RA its MCP joints
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13
Q

Treatment of psoriasis ?

A
  • Topical : coricosteriods, vit D3 analogue, retinoids and acetylic acid.
  • Systemic: retinoids, methotrexate and cyclosporine.
  • BIOLOGIC THERAPY
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14
Q

What is the peak age of onset of psoriasis ?

A

Two peaks. one at 20–30 years of age and a second peak at 50–60 years.

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15
Q

classification of psoriatic arthritis called?

A

moll and wright classification

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16
Q

Name the biological treatments of Psoriasis ?

A
  • Infliximab. (TNF-alpha)
  • Etanercept. (TNF-alpha)
  • Adalimab. (TNF-alpha)
  • Ustekinumab. ( IL 12/23)
17
Q

Which drug would u recommend to a patient with hypertension and severe psoriasis ?

A

Methotrexate.

18
Q

PASI score in severe psoriasis is :

A
  • More than 20.

- and u can use systemic TTT when more than 10

19
Q

Wax candle sign is ?

A

If the superficial silvery white scales are removed via curettage (grattage method), a characteristic coherence is observed, as if one has scratched on a wax candle (“signe de la tache de bougie”).

20
Q

Psoriasis, definition ?

A

is a chronic, immune-mediated dermatosis that results from a polygenic predisposition combined with environmental triggers.

21
Q

Which subtype of psoriasis is induced by rapid taper of systemic corticosteroids?

A
  • Pustular psoriasis (von Zumbusch) as well as flares of plaque psoriasis.
22
Q

Which clinical feature is the most common characteristic for psoriatic arthritis ?

A

Asymmetry of joints involvement.

23
Q

SPECIFIC PSORIASIS SIGNS ?

A
  • Wax candle sign.
  • Auspitz sign.
  • Köbner phenomenon.
24
Q

When do we use the term “inverse” psoriasis ?

A

When flexural areas are the only sites of involvement.

25
Q

Pustulosis of the palms and soles is associated with sterile inflammatory bone lesions, what are the symptoms ?

A

(SAPHO syndrome)

  • Synovitis.
  • Acne.
  • Pustulosis.
  • Hyperostosis.
  • Osteitis.
26
Q

Which treatment is the best choice before pregnancy for psoriasis ?

A

Cyclosporine.

27
Q

What are the changes in psoriasis Histologically?

A

_other:

  • Hyperkeratosis & parakeratosis.
  • Neutrophilis in the epidermis. (in spongiform or pustules of kogoj or microabscesses of munro)
  • Prominent angiogenesis.
  • Acanthosis of the epidermis.
  • Tortuous and dilated vessels and an inflammatory infiltrate composed primarily of lymphocytes are observed.
28
Q

What kind of psoriasis is frequently preceded by an upper respiratory tract infection (strep)?

A

Guttate psoriasis.

29
Q

AUSPITZ SIGN is ?

A

small bleeding after successive layers of scale have been removed.

30
Q

Psoriasis epidermis is chcara. by ?

A

Dyskeratosis ( abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum granulosum )

31
Q

CASPAR criteria are important to diagnose ?

A
  • Psoriasis arthritis.

MOAYAD - Dermatology Topics (22 decks)

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