PSY240 5. Substance Abuse Flashcards
(248 cards)
1
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Externalizing Disorders
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Externalizing Disorders
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Externalizing Disorders
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Substance use
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• Substance: Any product with psychoactive effects • ~50% have tried an illegal substance (U.S.) – 15% in the past year • Problematic use differs • Across the lifespan • Across different cultures
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Substance use
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Substance use
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Substance use
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Categories of Substances
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- CNS Depressants
- CNS Stimulants
- Opioids
- Hallucinogens and phencyclidine (PCP) 5. Cannabis
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Categories of Substances
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Categories of Substances
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Categories of Substances
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Substances Used
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Substances Used
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Substances Used
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Frequency of DSM-IV Disorders
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Frequency of DSM-IV Disorders
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Frequency of DSM-IV Disorders
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Frequency of DSM-IV Disorders
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Substance-Related Conditions (DSM-IV)
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• Substance intoxication: – Maladaptive symptoms due to effect of substance on CNS • Substance withdrawal: – Distress/impairment in function due to cessation/reduction of use
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Substance-Related Conditions (DSM-IV)
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Substance-Related Conditions (DSM-IV)
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Substance-Related Conditions (DSM-IV)
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Substance-Related Conditions (DSM-IV)
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• Substanceabuse: – Recurrent substance useharmful consequences • Substancedependence: – Recurrent substance use • physiological dependence • Significant impairment • Significant distress
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Substance-Related Conditions (DSM-IV)
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Substance-Related Conditions (DSM-IV)
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Substance-Related Conditions (DSM-IV)
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Substance Abuse (DSM-IV)
1+ symptoms occurs during a 12-month period:
1. Failure to fulfill important obligations
2. Repeated use in hazardous situations
3. Repeated legal problems
4. Use despite social problems
• Causes significant impairment or distress
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Substance Abuse (DSM-IV)
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Substance Abuse (DSM-IV)
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Substance Abuse (DSM-IV)
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Substance Abuse (DSM-IV)
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Substance Dependence (DSM-IV-TR)
Maladaptive pattern of substance use (3+):
1. Tolerance
2. Withdrawal
3. Substance taken in more/longer than intended
4. Persistent desire/unsuccessful efforts to cut back/control
5. Substance use is time-consuming
6. Important activities are reduced because of substance use
7. Use continued despite persistent problems
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Substance Dependence (DSM-IV-TR)
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Substance Dependence (DSM-IV-TR)
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Substance Dependence (DSM-IV-TR)
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Substance Dependence (DSM-IV-TR)
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Substance Dependence (DSM-IV-TR)
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Substance Dependence (DSM-IV-TR)
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CHANGES IN DSM-5: Criteria and Terminology
Diagnostic Thresholds
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CHANGES IN DSM-5: Criteria and Terminology
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CHANGES IN DSM-5: Criteria and Terminology
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CHANGES IN DSM-5: Criteria and Terminology
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CHANGES IN DSM-5: Criteria and Terminology
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CHANGES IN DSM-5: Criteria and Terminology
• Severity is based on the number of criteria endorsed: – Mild disorder: 2–3 criteria
– Moderate disorder: 4–5 criteria
– Severe disorder: 6+ criteria
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CHANGES IN DSM-5: Criteria and Terminology
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CHANGES IN DSM-5: Criteria and Terminology
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CHANGES IN DSM-5: Criteria and Terminology
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CHANGES IN DSM-5: Criteria and Terminology
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Changes in DSM-5
DSM-IV
| DSM-5
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Changes in DSM-5
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Changes in DSM-5
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Changes in DSM-5
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Changes in DSM-5
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Remission Status
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Remission Status
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Remission Status
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Alcohol Use
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Alcohol Use
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Alcohol Use
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Alcohol Use
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Alcohol Intoxication
* Mood
| * Behaviour • Physiology • Cognition
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Alcohol Intoxication
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Alcohol Intoxication
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Alcohol Intoxication
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Alcohol Intoxication
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Common Problems in Alcohol Use Disorder
* 80% Engaged in daily or weekly heavily drinking • 70% Consumed 1/5 (26er) of liquor in one day • 62% Family objects
* 59% Perceives self as an "excessive drinker"
* 31% Was arrested while drinking
* 21% Wanted to stop drinking but couldn't • 14% Continued to drink with serious illness
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Common Problems in Alcohol Use Disorder
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Common Problems in Alcohol Use Disorder
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Common Problems in Alcohol Use Disorder
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Common Problems in Alcohol Use Disorder
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Long-term Effects of Alcohol Abuse
* Low-grade hypertension
* Paranoia
* Deficits in memory and cognition
* Wernicke-Korsakoff ’s syndrome
* Alcohol-induced dementia
* Alcohol-induced persisting amnesic disorder
* Fetal alcohol syndrome
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Long-term Effects of Alcohol Abuse
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Long-term Effects of Alcohol Abuse
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Long-term Effects of Alcohol Abuse
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Long-term Effects of Alcohol Abuse
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Benzodiazepines and Barbiturates
• Benzodiazepines: Xanax, Valium, Halcion, Librium • Barbiturates: Quaaludes
– Legally manufactured – Sold by prescription
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
Signs of use/intoxication
• Mild euphoria
• Relief of tension, anxiety • Slurred speech
• Poor motor coordination • Impaired judgment
• Poor concentration
• Sleepiness
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
Long-term effects
• Chronic tiredness
• Breathing disorders • Vision Problems
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
Patterns of problematic use:
| 1. Adolescents’ recreational use 2. Increasing prescription dosage
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
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Benzodiazepines and Barbiturates
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Inhalants
* Solvents
| * Anesthetic gases and nitrates
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Inhalants
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Inhalants
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Inhalants
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Inhalants
Signs of use/intoxication
• paintorstainsonbodyorclothing • spotsorsoresaroundthemouth
• redorrunnyeyesornose
• chemicalbreathodor
• drunk,dazedordizzyappearance • nausea, loss of appetite
• anxiety,excitability,irritability
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Inhalants
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Inhalants
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Inhalants
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Inhalants
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Harmful Effects
• Brain damage, memory loss
• Hearing loss, Slurred speech
• Nose bleeds, loss of smell
• Suffocation, sudden death
• Irregular heart beat, heart attack
• Nausea, vomiting
• Liver damage, kidney damage
• Etc…
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Inhalants
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Inhalants
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Inhalants
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Inhalants
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Inhalants
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Chronic use
• Respiratory irritations, rashes
• Permanent CNS damage, organ failure, death
At-risk populations
• Prepubescent and early teen boys
• Aboriginal youth
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Inhalants
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Inhalants
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Inhalants
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Stimulants: Cocaine
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Affective/Cognitive symptoms:
• Euphoria
• Affective blunting
• Impaired judgment
Somatic Symptoms:
• Fight-or-flight response
• GI symptoms
• Seizures, coma
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Stimulants: Cocaine
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Stimulants: Cocaine
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Stimulants: Cocaine
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Stimulants: Cocaine
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Stimulants: Amphetamines
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Uses:
• Combat depression, fatigue
• Boost energy and self-confidence
• Appetite suppressant
• Symptoms similar to cocaine intoxication
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Stimulants: Amphetamines
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Stimulants: Amphetamines
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Stimulants: Amphetamines
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Stimulants: Amphetamines
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Amphetamines and Neurotransmitters
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Amphetamines and Neurotransmitters
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Amphetamines and Neurotransmitters
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Stimulants: Nicotine
• Affects CNS & PNS
• Releases DA, NE, 5-HT, endogenous opioids
• Withdrawal symptoms:
– https://www.youtube.com/watch?v=a7MIpyUpEcE
• No DSM-IV-TR diagnosis Æ new to DSM-5
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Stimulants: Nicotine
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Stimulants: Nicotine
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Stimulants: Nicotine
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Stimulants: Nicotine
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Stimulants: Caffeine
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• Most heavily used stimulant
– ~2 cups / day (U.S.)
– 1 cup = 100 mg caffeine
• Affects CNS
• Increases DA, NE, & 5-HT
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Stimulants: Caffeine
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Stimulants: Caffeine
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Stimulants: Caffeine
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Stimulants: Caffeine
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Stimulants: Caffeine
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Opioids
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Derived from the opiate poppy:
– Morphine
– Heroin
– Codeine
– Methadone
• Derived naturally from the body:
– Endorphins
– Enkaphalins
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Opioids
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Opioids
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Opioids
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Opioids
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Opioids
Intoxication
• Mood
• Cognition
• Physiology
Withdrawal
• Mood
• Physiology
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Opioids
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Opioids
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Opioids
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Opioids
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Hallucinogens and PCP
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Hallucinogens
• e.g., LSD, MDMA (ecstasy), and peyote.
PCP (angel dust)
• Snorted or smoked
• Not technically a hallucinogen, but has similar effects
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Hallucinogens and PCP
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Hallucinogens and PCP
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Hallucinogens and PCP
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Hallucinogens and PCP
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Cannabis
* Intoxication
* Mood
* Cognition
* Physiology
* Moderate to high dose may cause
* hallucinations
* depersonalization
* paranoia
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Cannabis
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Cannabis
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Cannabis
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Cannabis
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Non-Substance-Related Addictions
Examples: gambling, sex, exercise,
| video games, work, shopping, etc.
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Non-Substance-Related Addictions
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Non-Substance-Related Addictions
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Non-Substance-Related Addictions
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Non-Substance-Related Addictions
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Gambling Disorder
* A pattern of gambling behaviour that causes harm
* 12 month Canadian prevalence = ~ 2% (Cox et al., 2005)
* DSM Classification
* DSM-IV-TR: “Impulse-control disorders NOS”
* DSM-5: Non-substance-related disorder
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Gambling Disorder
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Gambling Disorder
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Gambling Disorder
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Gambling Disorder
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DSM-5 Section III Conditions
Hypersexual Disorder:
• A pattern of sexual behaviour that is initially pleasurable
but that becomes unfulfilling and self-destructive
Internet Gaming Disorder:
• Persistent and recurrent use of the Internet to engage in
games, often with other players
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DSM-5 Section III Conditions
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DSM-5 Section III Conditions
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DSM-5 Section III Conditions
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DSM-5 Section III Conditions
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DSM-5 Section III Conditions
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Concurrent Disorders
Comorbid mental health and substance use problems
• Complex and difficult to treat
Substance Use Treatment Seekers
Psychiatric Treatment Seekers
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Concurrent Disorders
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Concurrent Disorders
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Concurrent Disorders
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Concurrent Disorders: Stress & Trauma
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Impact influenced by
• Stressor
• Individual differences
• Gender
• Age
• Genes
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Concurrent Disorders: Stress & Trauma
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Stress/Trauma => Negative
Affect /
Somatic
Symptoms => Poor
Coping
Skills => Substance
Use =>Stress
Proliferation =>
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Concurrent Disorders: Stress & Trauma
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Concurrent Disorders: Stress & Trauma
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Concurrent Disorders: Stress & Trauma
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Concurrent Disorders: Stress & Trauma
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Concurrent Disorders: Stress & Trauma
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Concurrent Disorders: Anxiety & Mood Disorders
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Anxiety
• Risk of substance problems 2-5X higher
• In 75% of cases, anxiety came first
Bipolar Disorder
• Possible overlapping predispositions
• A “disorder-inducing disorder”
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Concurrent Disorders: Anxiety & Mood Disorders
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Concurrent Disorders: Anxiety & Mood Disorders
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Concurrent Disorders: Anxiety & Mood Disorders
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Concurrent Disorders: Anxiety & Mood Disorders
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Concurrent Disorders: Anxiety & Mood Disorders
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Concurrent Disorders: Psychosis
• Substance use can:
– Hasten onset of psychotic disorders
– Worsen symptoms and the course of illness
– Exacerbate negative consequences
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Concurrent Disorders: Psychosis
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Concurrent Disorders: Psychosis
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Concurrent Disorders: Psychosis
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Cultural Specificity
* Some cultures impose strict sanctions on all drugs
* Some cultures view it as a medical problem
* Some distinguish soft vs. hard drugs
* Some cultures normalize it
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Cultural Specificity
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Cultural Specificity
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Cultural Specificity
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Cultural Specificity
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Societal Costs
• Costs ~$14 billion CAD / year
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Societal Costs
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Motivational Models
• Desire for Mood Alteration
– Negative Affect Reduction (Emotionally vulnerable)
– Euphoria/Excitement Induction (Antisocial/Impulsive)
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Motivational Models
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Major Dopamine Pathways
| AKA “the reward pathway,” “the pleasure centre”
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Manufactured in
• Ventral Tegmental Area (VTA)
Released to
• Nucleus Accumbens
• Prefrontal Cortex
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Major Dopamine Pathways
| AKA “the reward pathway,” “the pleasure centre”
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Major Dopamine Pathways
| AKA “the reward pathway,” “the pleasure centre”
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Major Dopamine Pathways
| AKA “the reward pathway,” “the pleasure centre”
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Septal-Hippocampal Area
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• Connected via GABA-sensitive neurons
• ↑ GABA reduces anxiety
• ↓ GABA
– increases anxiety
– increased sensitivity to pain
– panic attacks, seizures
• Self-medicate with substances
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Septal-Hippocampal Area
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Septal-Hippocampal Area
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Septal-Hippocampal Area
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Genetic Factors
Behavioural Genetics Studies
• Moderate-to-high heritability
• Phenotypes (e.g., impulsivity) also heritable
Molecular Genetics Studies
• The role of specific genes is unclear
• Implicates gene variants linked to DA deficiency
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Genetic Factors
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Genetic Factors
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Genetic Factors
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Genetic Factors
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Psychological Theories
Behavioural
• Positive & Negative Reinforcement (self-medication)
• Modelling (parents, peers, culture, media)
• Maladaptive coping (comorbid social phobia)
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Psychological Theories
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Psychological Theories
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Psychological Theories
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Psychological Theories
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Dispositional
• Trait vulnerabilities
• Impulsivity
• Tendency to act without planning or restraint
• Strongest predictor of substance use
• Diathesis for substance use disorders
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Psychological Theories
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Psychological Theories
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Sociocultural Theories
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Adolescent Alcohol Use
• Experimentation
• Adolescents with alcoholic parents
• Stress in family home
• Opposite-sex friends
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Sociocultural Theories
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Sociocultural Theories
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Sociocultural Theories
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Sociocultural Approaches
* Chronic stress + support/promotion of use
* Advertising and media
* Gender differences
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Sociocultural Approaches
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Sociocultural Approaches
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Sociocultural Approaches
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Integrative Model
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Integrative Model
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Integrative Model
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Integrative Model
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Treatments
Alcoholics/Narcotics Anonymous
• “12-step” programs
• Total abstinence
• 27% AA members sober after 1 year
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Treatments
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Treatments
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Treatments
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Treatments
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Treatments
Biological Treatments:
• Antidepressants & Antianxiety agents
• Antagonists (block reinforcing effects)
• Agonists (e.g., Methadone)
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Treatments
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Treatments
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Treatments
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Treatments
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Behavioural
• Aversive classical conditioning
• Covert sensitization therapy
• Cue exposure and response prevention
• Controlled Drinking (controversial)
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Treatments
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Treatments
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Treatments
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Treatments
Cognitive
• Identify and gain control in risk situations
Motivational Interviewing (MI)
• Therapists express empathy, support self-efficacy
• Help clients explore and resolve ambivalence
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Treatments
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Treatments
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Treatments
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