Psych Drugs

Question 0

tricyclics - drugs?

Answer 0

#Amitriptyline
#Nortriptyline
#Imipramine

Question 1

SSRIs - drugs?

Answer 1

Fluoxetine
Fluvoxamine
Paroxetine
Sertraline
Citalopram
Escitalopram

Question 2

Tricyclics - adverse affects?

Answer 2

#Dry mouth
#Arrhythmias, hypotension, confusion
#G.I. disturbances, constipation, weight gain
#Sexual side effects

Question 3

MAOIs - drugs?

Answer 3

#Phenelzine
#isocarboxazid
#tranylcypromine

Question 4

MAOI – Side effects?

Treatment?

Answer 4

Hypertension with food with tyramine (Red wine, aged cheese, chocolate)

Alpha blocker

Question 5

SSRI adverse effects?

Answer 5

#Blurry vision, hypertension (opposite of tricyclics)
#G.I. disturbances, weight changes
#Sexual side effects

Question 6

Bupropion – adverse effect?

Mirtazapine?

Answer 6

seizures

Weight gain and sedation

Question 7

Lithium – adverse effects?

Answer 7

#Nephrotoxic, diabetes insipidus
#Thyroid dysfunction 
#Weight gain, G.I. disturbances, tremors (same as Valproic acid)
#Teratogenic (Ebstein's)
#Leukocytosis

Question 8

Severe lithium toxicity result in?

Answer 8

#Confusion
#Ataxia
#Lethargy
#Abnormal reflexes

Question 9

Valproic acid – adverse effects?

Answer 9

#Hepatotoxicity
#Alopecia

#Tremors, weight gain, G.I. disturbances (same as lithium)
#teratogenic (same as lithium)

Question 10

Single Most effective treatment for depression?

Answer 10

ECT

Question 11

Symptoms of serotonin syndrome?

Answer 11

#Cognitive – agitation, confusion, hallucinations, hypomania
#Autonomic – sweating, hyperthermia, tachycardia, nausea/diarrhea, shivering
#Somatic – tremors, myoclonus

Question 12

Treatment of serotonin syndrome?

Answer 12

#stop SSRI and symptomatic treatment
#Cyproheptadine (serotonin antagonist)

Question 13

MAOI in pregnancy - do you stop it?

Answer 13

Yes

Question 14

Long QT in MAOI - treatment?

Answer 14

sodium bicarbonate

Question 15

SSRI discontinuation syndrome?

Answer 15

#dizziness
#paresthesias

Question 16

Psychiatric drug class that inhibits platelet aggregation?

Which specific drug is contraindicated in pregnancy?

Answer 16

SSRIs;

Paroxetine

Question 17

Weight gain bigger problem with which SSRI?

Answer 17

Paroxetine

Question 18

SSRIs that is most likely to have drug-drug interactions? Least likely?

Answer 18

Fluoxitene and paroxetine

Citalopram and escitalopram

Question 19

Bupropion - MoA?

Answer 19

Increase dopamine and NE

Question 20

Bupropion - indications? Contraindications?

Do not give to? Why?

Answer 20

SAD, depression, smoking cessation

Seizures

Anorexics, alcoholics, epileptics; seizures

Question 21

Side effects of bupropion?

Answer 21

Headache, weight loss, insomnia, ANXIETY, SEIZURES

Question 22

Venlafaxine- MoA?

Complications?

Answer 22

SNRI (SSRI at lower doses)

SSRI side effects - decreased libido, erectile dysfunction, headaches, insomnia, “weird, wired, funny” feeling,

NE side effects - hypertension, xerostomia

Question 23

Duloxetine - mechanism? Indications?

Do not take if?

Answer 23

Bicyclic SNRI;

Neuropathic pain, MDD, fibromyalgia, musculoskeletal pain, urinary incontinence

Liver disease

Question 24

Duloxetine vs Venlafaxine?

Answer 24

SNRI vs SNRI at higher doses | Same side effects but Duloxetine also has worse nausea, and liver damage

Question 25

Anxious, cachectic, depressed old lady - consider?

Answer 25

Mirtazapine - increased weight gain/appetite, will make drowsy

Question 26

Valproic acid - side effects?

Answer 26

GI disturbances >>> neurologic, opthamalogic