Flashcards in Lange - Drugs 2 Deck (23)
Unlike typical neuroleptics, clozapine is much more potent and which receptor? Also, unlike typical neuroleptics, clozapine also acts at this receptor?
D4 antagonism > D2 antagonism
Which TCA should be used in the elderly?
Nortriptyline (less alpha-1 blocking means less orthostatic hypotension)
TCA's affect which receptors?
#alpha-1 and 2 antagonist
Only mood stabilizing medication that does not carry to teratogenic risk?
Drug to reduce agitation in delirious patients?
Risperidone or haloperidol
Cardiovascular side effects of TCAs? Patients with these cardiovascular conditions should not get these drugs?
TCA toxicity can have what cardiac effects?
#Widening of QRS
#AV conduction abnormalities
#Bundle branch block
Low potency Antipsychotics?
Orthostatic hypotension and anticholinergic effects
Role of Naltrexone in alcohol dependence?
#Decreases the number of days an alcoholic drinks
#Increases the time before relapse of heavy drinking
Cholinesterase inhibitors approved for use in the Alzheimer's dementia?
Donepezil and Tacrine
Neuroleptics that must be used carefully in the elderly?
Chlorpromazine (extrapyramidal symptoms and anticholinergic properties)
Detoxification from heroine can usually be managed with? How?
#Suppresses the sympathetic response to heroin withdrawal
#Controls agitation and autonomic instability
Antidepressants that may play a role in chronic pain management?
Yohimbine is used to treat? Mechanism? Should not be used by patients with history of?
Alpha 2 antagonist
#heart or renal disease
First-line agents for the treatment of primary insomnia?
Which is more contraindicated for patients with cardiac disease – TCAs or amphetamines?
TCAs – increased mortality
Class of drugs that are known to cause hyperglycemia and diabetes?
Specific drug has been shown to increase cholesterol levels?
Sialorrhea is a common side effect of which specific drug? Treatment?
Persistent cardiac effect of clozapine? Management?
Persistent sinus tachycardia
Which depressive symptoms respond first after antidepressant treatment?
Neurovegetative symptoms (SIGECAPS)
Drug that is approved to treat both depression and diabetic neuropathy?
Antidepressants that do not cause sexual dysfunction?