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Unlike typical neuroleptics, clozapine is much more potent and which receptor? Also, unlike typical neuroleptics, clozapine also acts at this receptor?

D4 antagonism > D2 antagonism

Serotonin 2

1

Which TCA should be used in the elderly?

Nortriptyline (less alpha-1 blocking means less orthostatic hypotension)

2

TCA's affect which receptors?

#Muscarinic antagonist
#alpha-1 and 2 antagonist
#Dopaminergic antagonist
#Histaminergic antagonist

3

Only mood stabilizing medication that does not carry to teratogenic risk?

Clonazepam (Klonopin)

4

Drug to reduce agitation in delirious patients?

Risperidone or haloperidol

5

Cardiovascular side effects of TCAs? Patients with these cardiovascular conditions should not get these drugs?

TCA toxicity can have what cardiac effects?

#Slows conduction

#Prolonged QT
#Widening of QRS
#AV conduction abnormalities

#Heart block
#Bundle branch block
#Tachyarrhythmias

6

Low potency Antipsychotics?

Adverse effects?

#chlorpromazine
#thiordazine

Orthostatic hypotension and anticholinergic effects

7

Role of Naltrexone in alcohol dependence?

#Decreases the number of days an alcoholic drinks
#Increases the time before relapse of heavy drinking

8

Cholinesterase inhibitors approved for use in the Alzheimer's dementia?

Donepezil and Tacrine

9

Neuroleptics that must be used carefully in the elderly?

Chlorpromazine (extrapyramidal symptoms and anticholinergic properties)

10

Detoxification from heroine can usually be managed with? How?

Clonidine

#Suppresses the sympathetic response to heroin withdrawal
#Controls agitation and autonomic instability

11

Antidepressants that may play a role in chronic pain management?

SSRIs

12

Yohimbine is used to treat? Mechanism? Should not be used by patients with history of?

Impotence

Alpha 2 antagonist

#heart or renal disease
#glaucoma
#Ulcers

13

First-line agents for the treatment of primary insomnia?

Benzodiazepines

14

Which is more contraindicated for patients with cardiac disease – TCAs or amphetamines?

TCAs – increased mortality

15

Class of drugs that are known to cause hyperglycemia and diabetes?

Atypical antipsychotics

16

Specific drug has been shown to increase cholesterol levels?

Olanzapine

17

Sialorrhea is a common side effect of which specific drug? Treatment?

Clozapine; propylthiouracil

18

Persistent cardiac effect of clozapine? Management?

Persistent sinus tachycardia

Propranolol

19

Which depressive symptoms respond first after antidepressant treatment?

Neurovegetative symptoms (SIGECAPS)

20

Drug that is approved to treat both depression and diabetic neuropathy?

Duloxetine (SNRI)

21

Antidepressants that do not cause sexual dysfunction?

#Mirtazapine
#Bupropion
#Nefazadone

22

Dopaminergic based side effects of antipsychotics?

#Prolactin (Galactorrhea, Gynecomastia)
#Extrapyramidal (blepharospasm, opisthotonos, torticollis)
#Pseudoparkinsonism
#Akathesia
#Rabbit syndrome