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4th Week > psych pharm > Flashcards

psych pharm Flashcards

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1
Q

Treatment for:

ADHD

A

methylphenidate

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2
Q

Treatment for:

alcohol withdrawal

A

Benzos

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3
Q

Treatment for:

Anxiety (3)

A

SSRI
SNRI
buspirone

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4
Q

Treatment for:

bipolar

A 
Mood stabilizers (Li, Valproic acid, carbamazepine)
atypical antipsychotics
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5
Q

Treatment for:

Bulimia

A

SSRIs

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6
Q

Treatment for:

Depression (5)

A 
SSRIs
SNRIs
TCAs
Bupropion
mirtazapine (especially with insomnia)
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7
Q

Treatment for:

OCD (2)

A

SSRI

clomipramine

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8
Q 
Treatment for:
Panic disorder (3)
A

SSRI
venlafaxine
benzodiazepines

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9
Q

Treatment for:

PTSD

A

SSRI

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10
Q

Treatment for:

Schizophrenia

A

antipsychotics

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11
Q

Treatment for:

social phobias

A

SSRIs

beta-blockers

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12
Q

Treatment for:

Tourettes

A

antipsychotics (eg haloperidol, rispiridone)

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13
Q

Methylphenidate MoA

A

CNS stimulant

increase catecholamines at synaptic cleft

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14
Q

Dextroamphetamine MoA

A

CNS stimulant

increase catecholamines at synaptic cleft

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15
Q

methamphetamine MoA

A

CNS stimulant

increase catecholamines at synaptic cleft

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16
Q

Phentermine MoA

A

CNS stimulant

increase catecholamines at synaptic cleft

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17
Q

how can you recognize a typical antipsychotic

A

haloperidol + “azine”s

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18
Q

MoA of typical antipsychotics

A

block D2 receptors –> increase cAMP

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19
Q

what are the high potency neuroleptics

A

Trifluoperazine, fluphenazine, haloperidol (try to fly high)

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20
Q

typical AEs of high potency neuroleptics

A

extrapyramidal symptoms

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21
Q

what are the low potency neuroleptics

A

Chlorpromazine, Thioridazine (cheating thieves are low)

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22
Q

what are typical AEs of low potency neuroleptics

A

anticholinergic, antihistamine, and alpha blocker effects

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23
Q

Which antipsych causes corneal deposits

A

Chlorpromazine

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24
Q

Which antipsych causes retinal deposits

A

Thioridazine

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25
Evolution of EPS side effects (4)
4 hours - acute dystonia 4 days - akinesia (parkinsonian) 4 weeks - akanthisia (restlessness) 4 months - tardive dyskinesia
26
what is acute dystonia, what is treatment?
muscle spasm, stiffness, oculogyric crisis (4 hours after) | - Tx: anti-cholinergic
27
What is Neuroleptic malignant syndrome. what is treatment
- muscle rigidity, myoglobulinuria, autonomic instability, fever - Tx: dantrolene, D2 agonists (bromocriptine)
28
What are the atypical antipsychotics (6)
``` olanzapine clozapine quetiapine risperidone aripiprazole ziprasidone its ATYPICAL for OLd CLOSets to QUIETly RISPER from A to Z ```
29
which atypical antipsych can be used for OCD, anxiety disorder, depression, mania, tourettes
Olanzapine
30
which atypical may prolong QT interval
Ziprasidone
31
Which atypical can cause agranulocytosis
Clozapine
32
Which atypicals can cause weight gain
Olanzapine and Clozapine | -Oh man... shes huge... shes going to need to restock her clozet
33
which atypical can cause lactation and gynecomastia
Risperidone (increases prolactin --> dec GnRH, LH, FSH) | RISe in prolactin
34
Lithium AEs
``` LMNOP Lithium side effects Movement (tremor) Nephrogenic diabetes insipidus hypOthyroidism Pregnancy probs (ebsteins) ```
35
Elimination of lithium
exclusively kidneys | most is reabsorbed with Na in proximal tubules
36
Buspirone MoA and use
5HT1A receptor agonist - treat generalized anxiety disorder - "im anxious if the BUS will be ON time"
37
how to recognize a TCA?
end in -iptyline or -ipramine | except doxepin and amoxapine
38
MoA of TCAs
block reuptake of NE and 5HT
39
TCA toxicity
- sedation - alpha 1 blocker (postural hypoTN - anticholinergic (atropine-like effects) - Tri-C's
40
What are the Tri-Cs of TCA tox
Convulsions Coma Cardiotoxicity
41
treatment for TCA cardiotoxicity
NaHCO3
42
Which TCA is less sedating?
Desipramine
43
what major AE is seen with desipramine
higher seizure incidence
44
what are the SSRIs
FLuoxetine, PARoxetine, SErtraline, CITalopram | FLashbacks PARalyze SEnior CITizens
45
MoA of SSRI
block serotonin reuptake
46
What is serotonin syndrome
``` hyperthermia myoclonus CV collapse flushing diarrhea seizures ```
47
treatment for serotonin syndrome
cyproheptadine (5HT antagonist)
48
SNRIs. name them
Venlafaxine Duloxetine (I've got a VD and I'm SNRI im not snorry)
49
MoA of venlafaxine
inhibit 5HT and NE reuptake
50
Venlafaxine used for depression and what else
GAD, and panic disorders
51
duloxetine used for depression and what else
diabetic peripheral neuropathy
52
Name the MAOIs
``` MAO Takes Pride In Shanghai Tranylcypromine Phenelzine Isocarboxazid Selegiline ```
53
Which MAO-I is selective for MAO-B | what does MAO-B do
selegeline | MAOB breaks down dopamine
54
MoA of MAO-Is
increases levels of amine neurotransmitters (NE, 5-HT, dopamine)
55
AE of MAOIs
Hypertensive crisis with tyramine. | can cause serotonin syndrome
56
Buproprion MoA
increases NE and doamine via unknown mechanism
57
Buproprion use
atypical antidepressant | smoking cessation
58
Buproprion AE
-stimulant effects SEIZURES in bullemics NO SEXUAL side effects
59
Mirtazapine MoA
alpha2 antagonist | potent 5HT2 and 5HT3 antagonist
60
Mirtazapine AE
sedation (useful if depressed person with insomnia) | - weight gain (Mirt makes you want zerts)
61
Trazodone MoA and use
primarily blocks 5HT2 and alpha1 receptors | - used for insomnia
62
Trazodone AE
sedation priapism postural hypoTN

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