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Psych Pharm Flashcards

(129 cards)

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1
Q

medication category for:

first generation- haloperidol

second generation- risperidone

A

antipsychotics

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2
Q

medication category for:

MAOIs

tricyclics, tetracyclics

SRIs or SRAs

SSRIs, SNRIs

atypical’s or NDRI’s

5HT1a agonist/5HT3 antagonist

SSRI/5HT1a partial agonist

A

antidepressants

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3
Q

medication category for:

lithium

anti-seizure drug- valproate

anxiolytics-antihistamine, anti-hypertensive, benzodiazepine

A

mood stabilizers

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4
Q

medication category for:

zolpidem

ramelteon

temazepam

suvorexant

ADHD meds

A

hypnotics

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5
Q

can neural circuits “learn” over time?

A

yes

over-stimulated circuits become dysregulated

  • circuit activity breaks down resulting in dysfunction
  • circuit dysfunciton is seen as symptoms
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6
Q

stimulate receptors

A

agonist

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7
Q

stimulate with ceiling & occupy receptor (which precludes other NT’s from attaching)

A

partial agonists

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8
Q

block agonist from receptor

A

antagonist

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9
Q

blocks agonists at receptor & reduce activity below baseline constitute activity

A

inverse agonist

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10
Q

psychiatric symptoms related to _______ _______

A

related to neural circuits

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11
Q

circuit contains ________ and ________

A

neurotransmitters and receptors

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12
Q

_______ activity drives symptoms

A

receptor

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13
Q

modulate receptor activity with ______

A

drugs

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14
Q

excess stimulation of the portions of the CNS that control motor function that are outside of the pyramidal tract

group of syndromes w/ signs of abnormal motor movement result from D2 antagonism (bradykinesia, incoordination, spasms)

A

extrapyramidal syndrome (EPS)

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15
Q

“late appearing dyskinesias”

a form of EPS

primarily orofacial dyskinesia

D2 receptor blockade

may be permanent

A

tardive dyskinesia

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16
Q

excess level of 5HT producing akithesia, muscle twitching, hyper-reflexia, penile erection, seizures, coma

A

serotonin syndrome

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17
Q

excess antagonism of D2 receptor producing muscle rigidity, fever, unstable BP, myoglobinemia

may be fatal

an extreme manifestation

A
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18
Q

genetically determined hypersensitivity to anesthetic agents resulting in severe hyperthermia, accelerated muscle metabolism, metabolic acidosis

A

malignant hypertension

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19
Q

syndrome including:

at a minimum, hallucinations, delusions

frequently also disorganized speech and behavior, gross distortions of reality testing

A

psychosis

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20
Q

drug class for haloperidol

A

first generation antipsychotic

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21
Q

indications for haloperidol

A

psychotic symptoms

(defining & associative symptoms)

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22
Q

MoA for haloperidol

A

D2 antagonist

inhibits alpha1, but not M1, H1

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23
Q

drug class for risperidone

A

SGA

atypical antipsychotic

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24
Q

indications for risperidone

A

psychosis (positive & negative symptoms)

mania

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25
MoA for risperidone
5HT and DA antagonist mild alpha1, alpha2, H1 antagonism
26
drug class for quetiapine
SGA atypical antipsychotic D2 & 5HT antagonist
27
indications for quetiapine
bipolar disorder schizophrenia adjunct in MDD off-label: GAD, OCD, PTSD
28
MoA for quetiapine
D2 and 5HT2 antagonism high affinity for M1 muscarinic receptors
29
drug class for lurasidone
SGA atypical antipsychotic D2, 5HT2, 5HT7 antagonist 5HT1a partial agonist
30
indications for lurasidone
schizophrenia bipolar 1 disorder
31
MoA for lurasidone
D2, 5HT2, 5HT7 antagonist 5HT1 partial agonist
32
drug class for ziprasidone
SGA
33
indications for ziprasidone
bipolar disorder schizophrenia acute agitation in schizophrenia
34
MoA for ziprasidone
D2, 5HT2a, 5HT1d antagonist 5HT1a agonist moderate 5HT and NE reuptake inhibition
35
what do we want to rule out before treating what looks like depression?
mania
36
what is the black box warning for all young adults for all antidepressants?
suicide risk
37
treatment goals: what is the success rate w/ antidepressants?
60-80%
38
after starting antidepressants, how long does it take to see improvements in emotions?
2-4 weeks
39
how long does it take to see the full impact of antidepressants?
6-8 weeks
40
drug class for phenelzine
monoamine oxidase inhibitor (MAOI)
41
indications for phenelzine
depression refractory to other Rx, ECT
42
MoA for phenelzine
inhibition of MAO producing increased NE, DA, 5HT
43
drug class for nortriptyline
tricyclic antidepressant
44
indications for nortriptyline
depressive disorders off-label: chronic pain, anxiety, enuresis, ADHD
45
MoA for nortriptyline
inhibit SERT, NET block 5HT2A receptors
46
drug class for mirtazapine
tetracyclic alpha2 antagonist
47
indications for mirtazapine
depression
48
MoA for mirtazapine
antagonism of alpha2 receptors dishibits 5HT, NE release; blocks NE negative feedback inhibits of NE, 5HT release
49
drug class for trazadone
SARIs 5HT2A, 5HT2C antagonist & reuptake inhibitors
50
indications for trazadone
MDD **insomnia** (lower doses)
51
MoA for trazadone
antagonist of 5HT2A, 5HTC and inhibits reuptake serotonin via SERT, reduces number of 5HT receptors & increasing 5HT flow in neuron
52
drug class for fluoxetine
selective serotonin reuptake inhibitor (SSRI)
53
indications for fluoxetine
MDD dysphoric disorder anxiety eating disorders OCD
54
MoA for fluoxetine
inhibit reuptake serotonin via SERT reducint number 5HT receptors & increasing 5HT flow in neuron; mild NRI, DRI, 5HT2C inhibition, CYP2D6 & 3A4 inhibition
55
drug class for sertraline
SSRI antidepressant
56
indications for sertraline
MDD PMDD PD PTSD social anxiety disorder OCD
57
MoA for sertraline
selectively inhibits SERT & increases 5HT level in synapse
58
drug class for citalopram
SSRI antidepressant
59
indications for citalopram
depression
60
MoA for citalopram
selectively inhibits SERT & mild antihistamine (H1) activity
61
drug class for venlafaxine
serotonin & NE reuptake inhibitors (SNERIs)
62
indications for venlafaxine
MDD GAD SAD panic disorder off-label: pain, OCD, hot flashes
63
MoA for venlafaxine
inhibits SERT at lower doses, NET at high doses
64
drug class for duloxetine
SNERI antidepressant
65
indications for duloxetine
MDD DPNP fibromyalgia GAD chronic MSK pain
66
MoA for duloxetine
elevates levels of 5HT, NE, and DA elevates DA levels in PFC
67
drug class for buproprion
NE, DA reuptake transporter inhibitors (NDRIs)
68
indications for buproprion
depression smoking cessation
69
MoA for buproprion
NE, DA reuptake inhibition
70
drug class for vortioxetine
SSRI
71
indications for vortioxetine
MDD
72
MoA for vortioxetine
inhibits SERT, partial agonist at 5HT1a and 5HT3 antagonist
73
drug class for vilazodone
SPARI (serotonin partial agonist reuptake inhibitor)
74
indications for vilazodone
MDD
75
MoA for vilazodone
inhibits SERT with elevatio of 5HT levels & has 5HT1a partial agonist activity
76
drug class for lithium
mood stabilizer
77
indications for lithium
bipolar disorder mania
78
possible SE/ADR of lithium
**diabetes insipidus**
79
drug class for valproate
anti-seizure med mood stabilizer
80
indications for valproate
seizure disorder mania aggression
81
MoA for valproate
increase GABA concentration
82
drug class for hydroxyzine
antihistamine (H1) anxiolytic
83
indications for hydroxyzine
anxiety, pruritis, sedation
84
MoA for hydroxyzine
inhibits H1 receptors
85
drug class for propanolol
beta blocker anxiolytic
86
indications for propanolol
HTN anxiety tremor hyperthyroidism
87
MoA for propanolol
nonselective beta blocker
88
drug class for diazepam
benzodiazepine anxiolytic
89
indications for diazepam
bridge therapy in anxiety disorders sedative, status epilepticus, alcohol withdrawal
90
MoA for diazepam
binds to & stabilizes BZD receptor on post-synaptic GABA neuron in limbic system & reticular formation enhancing GABA impact
91
drug class for oxazepam
benzodiazepine anxiolytic
92
indications for oxazepam
bridge therapy in anxiety disorders sedative, alcohol withdrawal
93
MoA for oxazepam
binds to & stabilizes BZD receptor on post-synaptic GABA neuron in limbic system & reticular formation enhancing GABA
94
drug class for buspirone
miscellaneous anxiolytic
95
indications for buspirone
anxiety
96
MoA for buspirone
5HT1A partial agonist modulates 5HT levels
97
drug class for zolpidem
non-benzodiaepine hypnotic
98
indications for zolpidem
short-term treatment insomnia
99
MoA for zolpidem
selective agonist for alpha1 subunit of BZD receptor of GABA receptor complex -\> increase GABA impact
100
drug class for esopiclone
hypnotic, nonbenzodiazepine
101
indications for esopiclone
insomnia
102
drug class for zaleplon
hypnotic nonbenzodiazepine
103
indications for zaleplon
short-term treatment insomnia
104
drug class for ramelteon
hypnotic miscellaneous
105
indications for ramelteon
insomnia
106
drug class for temazepam
hypnotic benzodiazepine
107
indications for temazepam
short-term treatment of insomnia
108
drug class for suvorexant
hypnotic orexin receptor antagonist
109
indications for suvorexant
insomnia
110
MoA for suvorexant
blockes wake-promoting orexin-A and orexin-B to receptors OX1R and OXR2 which suppresses wake drive
111
what are the 2 ADHD meds?
methylphenidate atomexetine
112
drug class for methylphenidate
CNS stimulant
113
indications for methylphenidate
symptomatic treatment of ADHD, narcolepsy off-label: depression in terminally ill
114
drug class for atomexetine
SNRI
115
indications for atomoxetine
ADHD
116
drug class for acamprosate
GABA agonist/glutamate antagonist
117
indications for acamprosate
maintenance of alcohol abstinence
118
drug class for disulfram
aldehyde dehydrogenase inhibitor
119
indications for disulfram
maintenance of alcohol abuse
120
drug class for naltrexone
opioid antagonist
121
indications for naltrexone
maintenance of alcohol or opioid absitnence off-label: cholestatic pruritis
122
drug class for methadone
opioid analgesic
123
indications for methadone
low doses- analgesia treatment of opioid addiction
124
drug class for buprenorphine
opioid partial agonist
125
indications for buprenorphine
analgesia opioid withdrawal dependence
126
drug class for naloxone
opioid antagonist
127
indications for naloxone
opioid overdose
128
drug class for buprenorphine & naloxone
opioid partial agonist & opioid antagonist
129
indications for buprenorphine & naloxone
maintenance herapy for opioid dependence \*not for induction of abstinence

Psych: SD & Pharm (5 decks)

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