Psychiatry Flashcards
(148 cards)
Delirium-DSM 5
A. Disturbance in attention and awareness
B. Disturbance develops over a short period of time, represents a change from baseline, and tends to fluctuate in severity over the course of a day
C. Additional disturbance in cognition (memory deficit, disorientation, language, visuospatial ability/perception).
D. Does not occur in the context of a severely reduced level of arousal (coma)
E. Evidence of physiological consequence as the cause
Causes of Delirium
- Substance Abuse
- Substance Withdrawal
- Medication-Induced
- Due to another medical condition
- Due to multiple etiologies
- Nutritional deficiencies
- Anemias
- Electrolyte imbalance
- Low ACh (Anticholinergics)
- High DA (Opioids)
Clinical Findings in Delirium
- Acute onset
- Inattention
- Disorientation
- Fluctuation of mental status
- Memory impairment
Pathophysiology of Delirium
- Inflammation (pro-inflammatory cytokines)
- Stress Rxn
- High coritsol
- Sleep deprivation
- Neuronal injury
- Disrupts BBB
- Neurotransmission abnormalities
- Decreased ACh
- Increased DA
Precipitating Factors of Delirium
- Medications: Anticholinergics/Opioids
- Hypoxia
- Hypoglycemia
- Hyperthermia/Fever
- Infection
- Metabolic Abnormalities
- Hypoalbuminemia (early sign)
Factors to reduce frequency of delirium
- Orientation protocol (write day/date/location/ID in sight)
- Noise reduction
- Visual aids
- Hearing aids
- Hydration
- Early mobilization
Drug Treatments for Delirium
- Benzodiazepines IF caused by withdrawal of ETOH or Benzodiazepines
- Pro-cholinergic drugs (AChE Inhibitors)
- DA antagonists (antipsychotics)
Major vs Minor neurocognitive disorder
Major: Substancial cognitive decline that interferes with independent living
Minor: Modest changes in cognition that do not yet interfere with independent living
Examples of major neurocognitive Disorders
- Alzheimer’s
- Vascular disease
- Prion Disease
- Parkinson’s
- Huntington’s
Changes in the brain in Alzheimer’s patients
- Amyloid plaques (beta amyloid peptides)
- Neurofibrillary tangles (tau protein)
- Loss of connections/cell death
- Loss of ACh
Symptoms of Alzheimer’s
- Memory loss***
- Loss of recognition
- language problems
- Anterograde amnesia
Drugs that treat alzheimer’s
- AChE inhibitors (inhibit ACh breakdown)
- NMDA antagonists
Risk Factors for Alzheimer’s
- Age
- Genetics for early-onset (chromosomes 1, 14, 21)
Most common cause of amnestic disorder
Alcohol abuse with chronic thiamine (B-1) deficiency
Symptoms of Wernicke’s Encephalopathy
- Ophthalmoplegia
- Ataxia
- Mental confusion
Symptoms of Korsakoff’s psychosis
- Amnesia (retrograde or anterograde)
What are the six cognitive domains in neurocognitive disorders?
- Attention
- Executivefunction
- Learning and memory
- Language
- Perceptual motor
- Social-cognition
Difference between Hallucination and Illusion
- Hallucination: seeing something that isn’t there (any of the 5 senses)
- Illusion: seeing something that is there but thinking that it is something else (see a rope but think it is a snake)
Mood vs Affect
- Mood: emotional attitude that is relatively sustained, self-reported
- Affect: the way the patient conveys their emotional state as perceived by others (how a patient “appears”)
Tegmentum: origin of which neurotransmitter?
Dopamine
Raphe nucleus: origin of which neurotransmitter?
Serotonin
Locus Ceruleus: origin of which neurotransmitter?
Norepinephrine
Tuberomammiliary nucleus: origin of which neurotransmitter?
Histamine
Nucelus Basalis of Meynert: origin of which neurotransmitter?
ACh