Psychiatry buzzwords Flashcards
(34 cards)
Third person auditory hallucinations
Schizphrenia
Mesocortical dopamine hypoactivity
Negative and cognitive symptomsinschizophrenia
Subcortical dopamine hyperactivity causes…
Psychosis
What is thetuberofundibular pathway in the brain concerned with?
Prolacin release
What is the nigrostriatal tract concerned with?
Extra-pyramidal motor movements
What is the mesolimic system invloved in?
Motivation & reward
What is the mesolimbic pathway dysregulated in?
Schizophrenia
How does Da blockade compare to Da agonism in terms of clinical pressentation?
Da blockade - Depression
Da agonism - psychosis
Side effects of clozapine
Agranulocyosis
Cardiomyocitis
Weight gain
Which of the atypical anti-psychotics causes the most weight gain?
Olanzapine
When is clozapine indicated?
When have been tried on 2 other anti-psychotics and need to be a consultant to prescribe
How is clozapine monitored?
Once a week for 6 months
Then once every 2 weeks fro 6 months then every 4 weeks thereafter and a month after discontinuation
What are the functions of the limbic system?
M2 - Memory, Motivation
O- Olfaction
V - Visceral afferents
E - Emotion
What are the brain changes in schizophrenia?
Reduced frontal lobe volume (and grey matter)
Enlarged lateral ventricles
Reduced grey matter in the temporal cortex
What is pressure of thought
Varied ideas in abundance (characteristic of mania but also seen in schizophrenia)
What is poverty of thought?
Patient reports lack/absence of thoughts
What is thought blocking?
Abrupt and complete interruption of stream (strongly associated with schizophrenia)
What is flight of ideas?
Quickly moving from one topic to anoher but there is a link unlike knights move thinking
What is knights move rhinking?
Quicly moving fromonetopic to another whenthere doesn’tseemtobealink
When is knights move thinking seen?
Inbipolar during mania
How are EP side effects treated?
Procyclidine
WHat is the role of the amygdala?
Involved in normal response to threat
What is the relationshipp between the PFC and the amygdala?
PFC dampens down amygdala response to threat
What s the steps of management of OCD?
- SSRI
- SSRI
- TCA or SSRI