Psychosis Flashcards

(84 cards)

1
Q

Define Psychosis

A

a mental state in which reality is greatly distorted

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2
Q

Name the three prevalent features of Psychosis

A
  1. Delusions
  2. Hallucinations
  3. Thought Disorder
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3
Q

Define Delusions

A

fixed false beliefs despite being contradicted by reality

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4
Q

How many types of common delusions are there? Name and explain them.

A

7
1. persecutory - most common, person fears they will be harmed (they are being spied upon or poisoned)
2. grandeur - believes they are much greater or more influential than they really are (really rich or president of the USA)
3. jealousy - fear spouse/partner is being unfaithful, more common in men, go to severe extents to find out if they are unfaithful (spying/detectives/ UNFAITHFUL).
4. love/erotomania - believes the person they are fixated with is massively in love with them, stalks them, jealousy and aggression can occur, usually with celeb or unknown person (STALKER).
5. somatic - tactile (feel bugs) or physical thing wrong with them (body part not working, think they smell funny)
6. Hypochondriasis - cough = tuberculosis = death
7. mixed - more than one of the previously mentioned delusions

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5
Q

What other types of delusions are there?

A
  • delusions of reference: TV is talking about them
  • delusion of control: external forces controlling thoughts, feelings or behaviours.
  • delusion of thought insertion, thought withdrawal & thought broadcasting (believes others can hear thoughts)
  • delusions of guilt
  • nihilistic delusions: believe they’re dead, lost organs etc.
  • bizarre: alien invasion
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6
Q

Name three ways of classifying delusions

A
  1. Cause
    - primary vs secondary (primary:occuring in the mind, no preceding reasons, secondary: can be understood due to the abnormality of another mental state issue)
  2. Mood
    - congruent vs incongruent (happy mood = mania, sad mood = depression/depressive thoughts, guilt etc.)
  3. Plausibility
    - bizarre vs non-bizarre (physically impossible beliefs vs potentially correct beliefs, being an alien vs being cheated on)
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7
Q

Name four organic causes of psychosis

A
  • drug induced
  • iatrogenic (steroids)
  • dementia
  • delirium (UTI)
    (Lyme disease/other medical conditions may induce psychosis)
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8
Q

define schizophrenia

A

The most common form of psychosis characterised by hallucinations, delusions, and thought disorders which lead to functional impairment

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9
Q

Give three PREDISPOSING risk factors for schizophrenia

A
  1. Substance misuse
  2. Family history
  3. Neurochemical imbalance (dopamine increased, GABA decreased).
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10
Q

Give two PRECIPITATING risk factors for schiophrenia

A
  1. Smoking cannabis
  2. Adverse life events
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11
Q

Give three PERPETUATING risk factors for schizophrenia

A
  1. Substance misuse
  2. Poor medication compliance & doses
  3. Lack of social support
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12
Q

What are Schneider’s First Rank Symptoms for Schizophrenia?

A
  1. Delusional perception
  2. Third-person auditory hallucinations (he looks awful today - talking about the pt.)
  3. Thought Interference (insertion, withdrawal & broadcasting)
  4. Passivity phenomenon (they have no control)
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13
Q

when can +ve symptoms be seen in schizophrenia?

A

all the time but normally in acute phases

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14
Q

Delusions Held Firmly Think Psychosis - this mnemonic stands for?

A

D - delusions
H - hallucinations
F - formal thought disorder (inability to continue conversations fluently)
T - thought interference (insert, withdrawal broad).
P - passivity phenomenon

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15
Q

When are negative symptoms normally seen?

A

chronic phase schizophrenia

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16
Q

Give six features of Negative Symptoms

A
  1. flat affect (no emotion in the face)
  2. reduced social interaction
  3. anhedonia
  4. avolition (less motivation/focus)
  5. alogia (speaking less)
  6. catatonia (moving less)
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17
Q

how many main subtypes of schizophrenia are there?

A

7

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18
Q

Name the subtypes of schizophrenia

A
  1. paranoid
  2. hebephrenia
  3. post schizophrenic depression
  4. catatonic
  5. simple
  6. undifferentiated
  7. residual
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19
Q

Define paranoid schizophrenia?

A

usually characterised by stable delusions, hallucinations (usually auditory), and perceptual disturbances.

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20
Q

Define Hebephrenic schizophrenia (disorganised)

A

aimless, disorganised behavior, rambling, incoherent speech, fleeting hallucinations and delusions, negative symptoms & inappropriate emotions (diagnosed in adolescence)

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21
Q

Define post-schizophrenic depression

A

schizophrenia in the last 12 months but not now, depressed. some positive symptoms may still be present but won’t dominate the picture

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22
Q

Define catatonic schizophrenia

A

dominated psychomotor disturbances, stupor and hyperkinesis and hyper excitement at some points and can have maintained postures

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23
Q

Define undifferentiated schizophrenia

A

meet the threshold but don’t fit into other categories

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24
Q

Define Residual Schizophrenia

A

chronic phase of schizophrenia, less prominent positive symptoms and more prominent negative symptoms

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25
Define Simple Schizophrenia
inability to function within society, loss of volition, and blunt affect (prominent negative symptoms related to SS), develop and proceed over psychotic symptoms.
26
What are the four symptoms in ICD10 Group A criteria of Schizophrenia
one or more required: - hallucinatory voices - thoughts echo, thought insertion/withdrawal, thought broadcasting (body limb thoughts) - delusions of control, influence, or passivity - persistent delusions that are culturally inappropriate and completely impossible, religion, political, superhuman powers
27
What are the five symptoms in ICD-10 Group B criteria of Schizophrenia
2 or more of the following: - persistent hallucinations in any form - breaks or interpolations in the train of thought - catatonic behaviour - negative symptoms - a significant and consistent change in the overall quality of personal behvaiour (anhedonia etc.)
28
interpolations meaning
insertions of something irrelevant into a sentence
29
what is required to diagnose schizophrenia from ICD10 categories?
1 from group A, 2 from group B
30
Name 4 lab investigations to diagnose schizophrenia
1. liver 2. prolactin 3. urine drug 4. urine dip
31
name 4 other investigations to diagnose schizophrenia
- BP - ECG - BMI - head CT
32
What type of pharmacological Tx is available for schizophrenics
typical and atypical antipsychotics
33
what does the typical and atypical drugs target
dopaminergic neurons in the nigostriatal, mesolimbic & tuberoinfundibular
34
4 examples of typical older drugs
1. chlorpromazine (tablets, liquids, injections, suppositories) 2. haloperidol (haldol) - rapid tranq 3. flupentixol (depixol) - tablets, depot 4. zuclopenthixol (clopixol) - tablets, depot
35
What ion does GABA receptors respond to and what ions influx to cause a reduce in membrane potential
GABA and chloride
36
Akathisia meaning?
Restlessness
37
Tardive dyskinesia meaning?
Typically involves the face and involves repetitive involuntary withdrawing movements (lip smacking, tongue protrusion and grimacing)
38
Parkinsonism meaning?
General term that mimics Parkinson’s disease (bradykinesia, cogwheel rigidity and shuffling gait)
39
Catatonia meaning?
Appear to be in stupor, maintain odd postures and appear awake but unresponsive to external stimuli
40
What suggests mania over Hypomania
Psychotic symptoms, 7 days or more - delusions of grandeur Several functional impairment Mood and irritability in both
41
First line treatments for bipolar (3)?
Psychological interventions, lithium and valproate
42
First line option of treatment for ADHD
Methylphenidate or lisdexamfetamine
43
Underlying cause of Korsakoff’s syndrome?
Untreated thiamine deficiency
44
What is WE (Wernickes encephalopathy)?how does it manifest? (4)
Acute deterioration in neurological function manifesting as nystagmus, ataxia, opthalmoplegia and/or encephalopathy
45
Persistent, recurrent WE can lead to what?
Korsakoff syndrome
46
Korsakoff is what?
Deficits in anterograde (no new memory) and retrograde memory that can lead to confabulation
47
What are key signs of psychotic depression
Mood-congruent delusions
48
Typical antipsychotics MOA
D2 receptor antagonists, blocking dopaminergic transmission in the mesolimbic pathways = increased dopamine
49
Adverse effects of typical antipsychotics
Extrapyramidal side-effects, hyperprolactinaemia
50
Examples of typical antipsychotics
Haloperidol, chlorpromazine
51
Atypical antipsychotics MOA
Act on a variety of recpetors D2, D3, D4, 5-HT)
52
Adverse effects of atypical antipsychotics
Extrapyramidal side effects and hyperprolactinaemia less common, metabolic effects
53
Examples of atypical antipsychotics
Clozapine, risperidone, olanzapine,
54
Examples of EPSEs
Parkinsonism Acute dystonia Akathisia Tardive dyskinesia
55
Examples of antimuscarinic side effects
- dry mouth, blurred vision, urinary retention, constipation
56
Atomoxetine MOA
Norepinephrine reuptake inhibitor
57
Zopliclone is what type of drug? MOA?
Non-benzo hypnotic acting on the alpha2-subunit of the GABA receptor
58
What are Z drugs
Zolpidem, zopiclone, zaleplon non-benzos that act on alpha 2 subunit gaba receptors
59
3 most common signs of ptsd
Re-experiencing Avoidance Hyperarousal (hypervigilance, sleep issues)
60
MOA behind the medication that leads to Tardive dyskinesia
Long term dopamine receptor blockade causing hypersensitivity of dopamine receptors in the nigrostriatal pathway
61
2 common medications that cause hyperprolactinaemia
Haloperidol and risperidone
62
What is the best management for OCD
ERP and CBT
63
What is an elementary hallucination
Buzzing, whistling etc
64
Guilty delusions are a symptom of what?
Psychotic depression
65
Persecutors delusions are suggestive of what?
Schizophrenia
66
When is lorazepam preferred over chlordiazepoxide?
Patients with hepatic failure
67
Flumazenil opposes the action of what?
Benzodiazepines
68
Alcohol withdrawal symptoms start?
6-12 hrs - sweating, tremor, tachy and anxiety 36 - seizures 48-72 - coarse tremor, confusion, delusion, auditory and visual halllucinations, fever tachy
69
First line treatment for patients with alcohol withdrawal
Long acting benzos - chlordiazepoxide or diazepam (lorazepam for hepatic failure pts) Carbamazepine Phenytoin is said not to be as effective in the tx of alcohol withdrawal seizures
70
Section 2?
Held for 28 days for review
71
Section 3?
6 months detained for review, can be viewed for further 6 months then another 12 months
72
Section 4
72 hours
73
Section 5
Holding powers, 6 hours and 72 hours
74
Benzos main side effect is?
Respiratory depression
75
Thiamine is vit what ?
Vit b1
76
Tuberoinfundibular pathway is related to what symtpoms
hyperprolactinaemia
77
Mesolimbic pathway is related to?
Positive symptoms
78
mesocortical pathways related to?
Negative symptoms
79
Nigrostriatal pathway is related to?
Parkinson’s
80
Corticospinal tract?
Movement
81
Explain how a D2 antagonist works
Block dopamine receptors reducing dopamine transmission and then dopamine levels
82
Precipitating meaning?
Trigger
83
Predisposing meaning?
Past relevant history
84
Perpetuating meaning?
Ongoing events not helping the behaviour