Psychotic disorders Flashcards

(61 cards)

1
Q

Schizophrenia characteristic symptoms

A

2 of following for >=1 mo

  • delusions
  • hallucinations
  • disorganized thinking/speech
  • grossly disorganized/abnormal motor behaviour

Negative symptoms
Social/occupational dysfunction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Schizophrenia diagnosis duration

A

6 mo

with 1 mo of characteristic symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Tragedy of schizophrenia

A
catastrophic illness
tends to persist
10% suicide rate
very common: 0.5-1% of popn
"cancer of mental illness"
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Complexity of schizophrenia

A
no single defining feature
multiple characteristic symptoms
symptoms from multiple domains:
- emotion
- personality
- cognition
-motor activity
probably multisystem disorder
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Negative symptoms of schizophrenia

A

Alogia
Affective blunting
Avolition
anhedonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Types of hallucinations in psychosis

A

auditory: common in schizophrenia, but also in alcohol withdrawal
visual: more common in drug-induced psychosis
tactile: more common in cocaine
olfactory: more common in temporal lobe epilepsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Persecutory delusions

A

theme of being followed/harassed etc

obstructed in pursuit of goals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Somatic delusions

A

that the person has some physical defect/general medical condition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Attenuated psychosis syndrome

A

A: at least 1/3 core psychosis symptoms with relatively intact reality testing, and warrants clincial attention
B: symptoms >=1x/week in past month
C: symptoms began or worsened in past year
D: not better explained by other mental disorder
E: criteria for another psychotic disorder never met

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Schizophreniform dx

A
symptoms of schizophrenia
confusion/perplexity
good premorbid functioning
absence of blunted affect
acute onset
>=1 month, but
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Schizoaffective disorder

A

Characteristic symptoms of schizophrenia + depressed, manic/mixed episode of mood
Delusions/hallucinations for >=2 weeks in absence of mood symptoms
Combination of schizophrenia + mood disorder
Specifiers: bipolar, depressive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Schizoaffective prognosis

A

better than schizophrenia but worse than mood disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Schizoaffectve treatment

A

usually require antipsychotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Delusional disorder diagnosis

A

non-bizarre delusions (paranoia, infection, deception, or having a disease) >=1 mo
Absence of meeting criteria for schizophrenia
FUnctioning not impaired
subtypes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Delusional disorder treatment

A

poor response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Brief psychotic disorder diagnosis

A

> =1 of:
delusions, hallucinations, disorganized speech ,disorganized behaviour
episode cannot be a culturally sanctioned response/better explained by another mental disorder, substance, or medical condition
often concurrent with severe stressors
=1 day but

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Medical conditions that may present with psychosis

A
temporal lobe epilepsy
tumor
stroke
trauma
endocrine/metabolic abnormalities
infections
MS
AI disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Substance-induced psychotic disorder features

A

specific onset during intoxication/withdrawal
prominent hallucinations/delusions without insight
evidence symptoms develop during/within 1 mo of substance intoxication or withdrawal

Amphetamines, marijuana, hallucinogens, cocaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Schizotypal personality disorder features

A

Pervasive pattern of social/itnerpersonal deficits marked by acute discomfort with, and reduced capacity for, close relationsihps
cognitive/perceptual distortions, eccentricities of behaviour
beginning by early adulthood and present in a variety of context, as indicated by >=5 of:
ideas of reference, odd beliefs/magical thinking, unusual perceptual experiences, odd thinking and speech, suspiciousnessor paranoid ideation, inappropriate or constricted affect, behaviour/appearance that is odd, lack of close friends or confidants, excessive social anxiety
Syndrome does not occur exclusively during courseo f schizophrenia, a mood disorder with psychosis, other psychotic disorders, or autism spectrum disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Major depressive disorder with psychotic features

A

MDD - >=5 symptoms, 2 week period with functional impairment
cannot be attributable to substance use, other medical conditions, or other psychiatric illnesses including schizoaffective disorder/bipolar disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Bipolar disorder with psychotic features

A

Mania - >=1 week with functional impairment

cannot be attributable to substance use, other medical conditions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Neurodevelopmental hypothesis of schizophrenia

A

developmental “insult” occurs during fetal period but is only manifested as psychotic symptoms after puberty
one or more insults may occur in utero, perinatal, childhood, or adolescence
Developmental changes lead to altered brain structure/function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Child development - schizophrenia

A

impairments of motor, cognitive and social function in childhood, years before onset of psychosis
delyaed walking, speech problems and lower scores on school tests

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Birth complications - schizophrenia

A

greater number of birth complications than controls

e.g. Rh incompatibility, preeclampsia, low birth weight, hypoxia, gestational diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Gross pathology - schizophrenia
enlargement of lateral/3rd ventricles ventricular size: vary widely, only larger in some patients, increased in other situations small reduction in total brain weight - more pronounced in temporal lobe (hippocampus) and frontal, correlates with poor function during life pathology present at onset of illness
26
Microscopic pathology - schizophrenia
alteration in position of neurons abnormal cell migration during critical period of prenatal brain development - cerebral cortex forms improperly --> aberrant connections and abnormal NT Symptoms evolve over course of illness brain tissue loss over time greater in schizophrenia, highest close to disease onset decreased brain volume may reflect a reduction in amount of neuropil size/complexity of neuronal dendrites reduced - neurons slightly smaller - dendritic spines reduced Abnormal amount or function of synaptic proteins
27
Dopamine hypothesis in psychosis (primary)
Drugs that Decrease DA --> alleviate psychosis - antipsychotics (antagonist at DAD2), clinical effectiveness related to D2 receptor affinity Drugs that Increase DA can cause psychosis - L-dopa in PD - illicit drugs
28
Limitations of dopamine hypothesis (primary) in psychosis
explains positive but NOT negative symptoms/cognitive impairment negative/cognitive symptoms not well-controlled by typical antipsychotics; not brought on by use of cocaine/amphetamine
29
Revised dopamine hypothesis
Imbalance in brain DA Increased DA in subcortical regions (nucleus accumbens) --> positive symptoms Decreased Da in prefrontal cortex --> negative symptoms, cognitive deficit Increased DA synthesis capacity/release in respones to amphetamine in striatal regions Distinct regional distribution of dopamine receptors Decreased dopamine activity in the PFC --> increased DA activity in striatal regions Increased striatal dopamine transmission associated with psychosis DA not only NT involved - antipsychotics do not only bind at DA receptors - substances that act on other NT systems can also produce psychosis
30
Dopamine at the synapse
Antipsychotics: block D2 receptor post-synaptic Cocaine: block reuptake Amphetamines: reversal of reuptake increase level of DA from presynaptic membrane decrease MAO breakdown
31
Nigro-striatal pathway
role in control of voluntary movement as the part of the extrapyramidal system antipsychotic blockade at D2 may precipitate EPS
32
Mesolimbic pathway
VTA-nucleus accumbens emotion/reward posotive symptoms
33
Mesocortical pathway
VTA - PFC motivation/cognition negative symptoms
34
Tuberoinfundibular pathway
Hypothalamus - pit DA inhibits prolactin release antipsychotic may lead to galactorrhea, amenorrhea, sexual dysfunction
35
Schizophrenia/Glutamate
schizophrenia associated with NMDA receptor hypofunction Phencyclidine (PCP) and ketamine - NMDA antagonists; can mimic positive/negative symptoms, exacerbate symptoms ubiquitously distributed in CNS can determine dopamine release, leading to changes in DA transmission similar to those seen in schizophrenia
36
Serotonin - schizophrenia
hypothesis suggests psychosis could result from increased 5HT transmission LSD: can produce psychosis - mimic serotonin; act through 5HT2A some atypical antipsychotics also act at 5HT2A serotonin system also regulates dopaminergic tone
37
Other pathophysiological causes of schizophrenia
GABAergic interneurons - direct influence on glutamatergic regulation of dopamine cholinergic system - disruption in DA balance?
38
MOA of 1st generation antipsychotics
D2 mesolimbic: antipsychotic D2 mesocortical: neuroleptic-induced deficit syndrome - increase negative symptoms D2 nigrostriatal: EPS D2 tuberoinfundibular - increase PRL blockage of D2 at all pathways
39
Side effects of 1st gen antipsychotics
H1: sedation, weight gain alpha1: decreased BP, dizziness, drowsiness M1: dry mouth, urinary retention, blurred vision, constipation
40
1st gen antipsychotic - low affinity
Chlorpromazine | SE related to H1, alpha1, M1 receptor antagonism - sedation, weight gain, orthostatic hypotension, urinary retention
41
1st gen antipsychotic - high affinity
Haloperidol pimozide perphenazine SE related to D2 antagonism - EPS
42
1st generation antipsychotic characteristics
D2 antagonist neuroleptic induced deficit syndrome EPS increase in prolactin
43
2nd generation antipsychotic characteristics
``` D2 antagonist + 5HT2A antagonist REDUCED: - neuroleptic induced deficit syndrome - EPS - prolactin ```
44
2nd gen antipsychotic examples
``` Clozapine aripirazole - pines -idones long-acting injectibles ```
45
Usage of 1st vs 2nd gen antipsychotics
no clear/consistent difference between 1st gen/2nd gen agents with regards to treatment respones to positive symptoms with exception of clozapine for tx-resistant patients 2nd gen maybe better than 1st gen for negative symptoms 2nd gen have greater propensity to cause metabolic side effects (weight gain, DM, dyslipidemia, metabolic syndrome)
46
EPS symptomatic treatment
due to decrease dopaminergic, increased cholinergic transmission M1 pharmacological treatment: anticholinergic - benztropine, trihexphenidyl note: some antipsychotics have potent anticholinergic effects --> inherent protection against EPS
47
5HT1A antagonism
antidepressant anxiolytic reduces EPS, negative symptoms
48
5HT2A antagonism
reduces EPS, potentially reduces negative symptoms
49
Psychosis treatment guidelines
1) Trial of a single atypical (2 weeks) 2) trial of a different atypical ) 3) trial of a single atypical or conventional OR trial of clozapine 4) augmentation clozapine + Li, anticonvulsants, antidepressants, ECT 5) combination Atypical+ atypical or atypical + conventional
50
Changing antipsychotics
threshold for deciding to change antipsychotic due to side effects should be low some can be treated with adjunctive medication some decrease with time (wait 4-6 weeks if patient is benefitting from medication) multiple medications could cause side effects
51
Tx of acute dystonia (antipsychotic)
prevalence: 10%; more common in young males, neuroleptic naive and with high potency antipsychotics can occur within hours of starting antipsychotics patient may not be able to swallow - can give iv, im Tx: anticholinergic benztropine dipenhydramine
52
Tx of pseudo-Parkisonism (antipsychotic)
prevalence: ~20% more common in elder females and those with pre-existing neurological damage can occur days - wks after antipsychotic started/increased Tx: reduce dose of antipsychotic change antipsychotic treat with oral anticholinergic - monitor q 3 mo don't prescribe at night since symptoms are absent during sleep
53
Tx of akathisia due to antipsychotics
prevalence ~25% less with atypicals occurs within hours - wks of starting/increasing dose internal dysphoric restlessness Tx: reduce dose of antipsychotic propranolol benzodiazepine can use propranolol + benzo
54
Tx of tardive dyskinesia due to antipsychotics
Prevalence: ~5%/y of antipsychotic exposure moe common in elderly women, those with affective illness and those that develop EPS occurs mo-yrs, 50% reversible repetitive purposeless movements that worsen under stress stop anticholinergic if prescribed Tx: reduce dose of antipsychotic change to atypical antipsychotic switch to clozapine/quetiapine
55
Tx of neuroleptic malignant syndrome due to antipsychotics
risk factors: young male, neurologic disabilities, dehydration, exhaustion, agitation, rapid/parenteral administration of AP reported with all antipsychotics sympathetic hyperactivity due to dopaminergic antagonism + psychological stressors muslce rigidity, confusion, fluctuating LOC, diaphoresis, fever, hyperthermia, fluctuating BP, tachycardia Tx: d/c antipsychotic bromocriptine (D2 agonist) + Dantroline (muscle relaxant) amantidine (D2 agonist)
56
Tx mild sedation + psychosis
lorazepam +/- risperidone, olanzepine, or quetiapine
57
Tx moderate sedation + psychosis
Lorazepam + loxapine / haloperidol (lorazepam + haloperidol reduces incidence of EPS) Haloperidol + antihistamine Olanzepine im
58
Tx extended period of sedation + psychosis
Zuclopenthixol acetate | not for those who are naive to antipsychotics
59
Tx insomnia in the context of psychosis
benzodiazepine zopiclone trazodone prn prn for insomnia should be time-limited
60
Tx persistent symptoms of aggression/hostility/mood liability
``` mood stabilizer (valproic acid, lithium, carbamazepine) if partial/non-response, use clozapine ``` Clozapine can increase the risk of seizures at high doses
61
Tx depression in schizophrenia
not in acute phase SSRI, venlafaxine XR, buproprion SR, mirtazapine use another if partial/non-responsive depression/suicide common in schizophrenia some antidepressants can cause akathisia