pulmonary arterial HTN

Question 1

a mPAP over what indicates pulm HTN

Answer 1

25

Question 2

what drugs cause pulm htn

Answer 2

cocaine
SSRI (during preg)
wt loss drugs

Question 3

what is the pathophys behind pulm htn

Answer 3

-imbalance of VC/VD (inc VC- endothelin and thromboxane, dec VD- prostacyclins)
-imbalance of proliferation (arteries thicken –> scar tissue forms)

Question 4

what electrolyte should you restrict in diet

Answer 4

sodium

Question 5

if pt responds positive to the acute vascoactive testing, what should they be started on

Answer 5

oral CCB

Question 6

what CCB should be avoided

Answer 6

verapamil

Question 7

if pt responds negative, what should they start

Answer 7

-prostacyclins (if sev, use IV)
-endothelin receptor antagonists
-PDE-5

Question 8

prostacyclins is a potent

Answer 8

VD
-and inhibits platelets

Question 9

what is a notable SE of prostacyclins

Answer 9

jaw pain
-edema, anxiety, GI, dizzy

Question 10

PC can be life threatening if

Answer 10

stopped suddenly
-half life of epo is 5 mins vs treproos is 4 hrs

Question 11

what are the imp things to know ab IV admin of PC?
-line?
-changed how often?

Answer 11

central line
IV cassette or SC syringe, change q 1-3 days

Question 12

what are the PDE-5 used

Answer 12

sidenafil (revatio) or tadalafil (adcira)

Question 13

what is the dosing for sidenafil and tadalafil

Answer 13

-20 mg TID (4-6 hr apart)
-40 mg daily

Question 14

endothelin receptor anagonists are a ___ drug

Answer 14

REMS