Purines

Question 1

Name tei pathways if obtaining GMP & AMP

Answer 1

De novo synthesis
Salvage pathway

Question 2

What catalyses the first committed step in purine metabolism

Answer 2

Glutamine phosphorybosyl phosphate (PRPP)

Question 3

Which purine can be salvaged by the two step pathway

Answer 3

Adenine

Question 4

Gout disorder is due to ?
Give of two types. Of primary gout is inherited?

Answer 4

Unric acid in blood stream
Primary metabolic gout-due to inherited metabolic defect in purine metabolism leading to excess rate of conversion of glycine to uric acid

Question 5

What is due to failure of excretion of uric acid

Answer 5

Primary renal gout

Question 6

Name 3 types of secondary gout?

Answer 6

Secondary metabolic
Secondary renal
In von gierke disease

Question 7

What is good substrate for PRPP Synthetase

Answer 7

HMP

Question 8

Name to treatments gor gout?

Answer 8

Palliative treatment
Specific treatments eg reduction of uric synthesis by using allopurinol

Question 9

Allopurinol when acted upon by xanthibe oxidase is converted to?

Answer 9

Alloxanthine

Question 10

What does allopurinol do?

Answer 10

Reduces uric acid levels and in increases xanthine and hypoxanthine concentration in blood which are more soluble thus easily excretion in urine

Question 11

Z