qc lab midterm

Question 1

refers to the depth or extent from one surface to another surface.

Answer 1

Tablet thickness

Question 2

solid dosage forms usually obtained by single or multiple compression of powders or granules. in certain cases tablets may be obtained by molding or extrusion techniques, they are uncoated or coated

Answer 2

Tablet

Question 3

a straight line passing from side to side through the center of the tablet

Answer 3

Diameter

Question 4

the distance between the top and bottom or front and back surface of the tablet

Answer 4

Thickness

Question 5

Tablet diameter should be controlled within a _____________________________

Answer 5

+ - 5% variation of standard value

Question 6

Also known as “crushing strength”.

Answer 6

Tablet Hardness

Question 7

refers to the resistance of the tablet to chipping, abrasion or breakage under conditions of storage, transportation, and handling before usage.

Answer 7

Hardness

Question 8

The test is done by application of a load
to the edges of a tablet across a
diameter. The load is gradually increased
until the tablet fractures or break. The
value of the load at this point (crushing
force) gives a measure of the hardness of
the tablet. 3 samples are used and the
mean value is determined.

Answer 8

Hardness Test

Question 9

Tablet hardness tester models:

Answer 9

• Monsato Tester
• Strong-Cobb Tester
• Pfizer Tester
• Erweka Tester
• Schleuniger Tester
• Pharma Test
• Microspan Contesar

Question 10

Most primitive way and practical test for hardness of tablets

Answer 10

Rule of Thumb

Question 11

Describes a tablet to be of proper hardness if it was firm enough to break with a sharp snap when it was held between the 2nd and 3rd fingers using thumb as fulcrum, yet didn’t break when it fell on the floor.

Answer 11

Rule of thumb

Question 12

What is the Monsanto tester used for?

Answer 12

Measuring tablet hardness using a spring-loaded screw mechanism.

Question 13

• It is a hand operated device in the form of a plated metal cylinder, about 150mm in length and 25 mm in diameter.
• Also known as the Stokes Hardness tester

Answer 13

Monsato Tester

Question 14

What is the acceptable range of the monsato tester?

Answer 14

4 to 10 kg- ordinary compressed tablets
2 kg- sublingual tablets
2 kg- chewable tablets
10 kg- buccal tablets

Question 15

• Like Stokes Monsato, it also measures the diametrically applied force required to break a tablet.
• measures the applied force in Kg required to break a tablet across its diameter. The force is produced by a manually or pressure operated pump.

-Air pump

Answer 15

Strong-Cobb Tester

Question 16

Plier-style hardness tester with a spring compression system.

• Tablet is crushed in between the jaws of the device. The force is indicated on the dial indicator.

Answer 16

Pfizer Tester

Question 17

Uses the principle of a steelyard balance to load a vertically sliding jaw by means of weighted beam.

-Suspended weight

Answer 17

Erweka Tester

Question 18

• Also known as Heberlein Model
• Most widely used instrument for tablet hardness test
• The earliest version of this instrument had no motor drive, but were operated by means of a handwheel.
• Uses an ingenious arrangement of levers
• Platens

Answer 18

Schleuniger Tester

Question 19

Apparatus manufacturers from West Germany

Answer 19

Pharma Test

Question 20

• Designed with the object if providing measurement not only of tablet hardness, but also thickness and weight.
• This machine is unique that it can accept mixed batches of tablets of different shapes and sizes, automatically moving them to stations for the successive measurement of thickness, weight and hardness.

-can print out statistical analysis

Answer 20

Microspan Contestar

Question 21

determines the percentage loss on tablet
in packaging, handling, and shipping.

Answer 21

Friability test

Question 22

Makes use of a tumbling apparatus where tablets are exposed to rolling and repeated shocks from free fall within the apparatus.

Conditions: 100 revolutions in 4 minutes.

Answer 22

Roche Friabilator

Question 23

How many tablets are used if the tablet weight is more than 650 mg?

Answer 23

10 tablets

Question 24

How many tablets are used if the tablet weight is 650 mg or less?

Answer 24

20 tablets

Question 25

What is the maximum acceptable weight loss for a batch to pass the friability test?

Answer 25

Not more than 1%

Question 26

What happens if the weight loss exceeds 1%?

Answer 26

The test must be repeated twice and averaged

Question 27

What tool is used to clean tablets before and after testing?

Answer 27

A #10 sieve with air pressure or soft brush

Question 28

Consist of 12 standardised internal plastic baffles used to test the abrasion strength of the tablets

Answer 28

Abrasion Drum

Question 29

Infrared radiation was discovered by_______________ in 1800.

Answer 29

Sir William Herschel

Question 30

___________________ is the study of interaction of electromagnetic waves (EM) with matter.

Answer 30

Spectroscopy

Question 31

0.7 µm to 2,5 µm

Answer 31

NIRS

Question 32

2,5 µm to 25 µm

Answer 32

MIRS

Question 33

25 µm to 300 µm

Answer 33

FIRS

Question 34

________________ is the study of the interaction of matter with light radiation when waves travel through the medium (matter).

Answer 34

Infrared spectroscopy

Question 35

If there is no polarity (dipole moment) in the molecule then the infrared interaction is ________ and the molecule does not produce any IR spectrum.

Answer 35

inactive

Question 36

The name atom was coined by _________from the Greek, α-τέµνω, meaning in Greek it cannot be cut any more or it is indivisible.

Answer 36

Democritus

Question 37

The _________ is a combination of periodically changing or oscillating electric field (EF) and magnetic field (MF) oscillating at the same frequency, but perpendicular to the electrical field.

Answer 37

EM radiation

Question 38

The ______________ is designed to analyze monochromatic (“one color”) light that passes through a solution.

Answer 38

colorimeter

Question 39

The measure of the amount of light that passes through a solution is called _______________ it is a ratio of the intensity of the transmitted light to the intensity of the original light and is usually expressed in percentage.

Answer 39

Transmittance

Question 40

Flame spectroscopy is used in the assay of lithium carbonate, an antidepressant agent. This technique is used for the assay of other elements such as potassium, sodium, and calcium in blood and other biological samples.