Qual Control

Question 1

involves the SYSTEMATIC MONITRING OF ANALYICAL PROCESSES to detect analytic errors that occur during analysis and to ultimately prevent the reporting of incorrect patient test results

Answer 1

QUALITY CONTROL

Question 2

Application of multirule systems

Answer 2

WESTERGARD RULE

Question 3

Plotting data

Answer 3

LEVEY JENNINGS CHART

Question 4

“Setting” the analyzer to give correct results

Answer 4

CALIBRATION

Question 5

Checking”
- If the analyzer is producing correct results

Answer 5

QUALITY CONTROL

Question 6

Run along-side patient samples and results

Answer 6

QUALITY CONTROL

Question 7

Run prior to QC manually

Answer 7

CALIBRATION

Question 8

Refers to the substance or base from which the control material is prepared.

Answer 8

MATRIX

Question 9

3 TYPES OF CONTROL MATERIALS

Answer 9

ASSAYED
UNASSAYED
HOME MADE OR IN HOUSE

Question 10

Target value PREDETERMINED

Answer 10

ASSAYED

Question 11

• Commonly used in the laboratory
• Manufacturer gives CONTROL MATERIAL AND RANGE for comparison

Answer 11

ASSAYED

Question 12

● Target values not PREDETERMINED
● Full assay to be established

Answer 12

UNASSAYED

Question 13

Manufacturer gives CONTROL MATERIAL W/O RANGE

Answer 13

UNASSAYED

Question 14

● Pooled sera collected in the laboratory
● Full assay, validation needed
○ No manufacturer

Answer 14

HOME MADE OR INHOUSE

Question 15

Describes the CLOSENESS of a test value to the actual/target/true valu

Answer 15

ACCURACY

Question 16

ACCURACY can be measured in 3 ways

Answer 16

(RIC)

Recovery study
Interference method
Comparison of methods of study

Question 17

● Patient sample is added concentrated analyte of interest
● Accurate machine → INCREASED RESULT even if sample has other analytes present

Answer 17

Recovery study

Question 18

Interfering substances REFLECT/ABSORB light and REACT with reagents.
● Accurate Machine → Machine WON’T CHANGE RESULTS with the presence of interfering substances

Answer 18

INTERFERENCE STUDY

Question 19

Gold standard method

Answer 19

HPLC

Question 20

Accurate Machine → If lab result (recovery study) is CLOSE to gold standard (interference study) result

Answer 20

COMPARISON OF METHODS OF STUDY

Question 21

Degree of REPLICATION of data

Answer 21

PRECISION

Question 22

Ability of analytical methods to give REPEATED results on the same sample that agree with one another.

Answer 22

PRECISION

Question 23

Capacity to produce the SAME RESULTS ON ONE SAMPLE again and again when performed by the SAME individual using the SAME lot numbers on the SAME instruments..

Answer 23

REPEATABILITY/PRACTICABILITY

Question 24

Capacity of the method to produce the SAME RESULTS ON THE SAME SAMPLE again and again when performed by DIFFERENT individuals on DIFFERENT days using DIFFERENT sets of reagents.

Answer 24

REPRODUCIBILITY

Question 25

Ability of ANALYTICAL method to measure the SMALLEST CONCENTRATION of the analyte of interest

Answer 25

ANALYTICAL SENSITIVITY

Question 26

Ability of an ANALYTICAL method to measure ONLY the analyte of interest

Answer 26

ANALYTICAL SPECIFICITY

Question 27

Ability of the test to detect the proportion of individuals W/ THAT DISEASE who test POSITIVELY with the test

Answer 27

DIAGNOSTIC SENSITIVITY

Question 28

Ability of the test to detect the proportion of individual W/O THE DISEASE who test NEGATIVELY for the disease

Answer 28

DIAGNOSTIC SPECIFICITY

Question 29

NRL for Dengue, Influenza, TB, and other Mycobacteria.

Answer 29

Research Institute for Tropical Medicine

Question 30

NRL for - Anatomic Pathology for Pulmonary Disease - Biochemistry, Clinical Chemistry

Answer 30

Lung Center of the Philippines

Question 31

NRL for - Hematology, Immunohematology - Immunopathology, Anatomic Pathology

Answer 31

National Kidney and Transplant Institute

Question 32

NRL for - Environmental and Occupational Health - Toxicology (drug testing) - Micronutrient Assay (confirmatory test for drug test)

Answer 32

East Avenue Medical Center

Question 33

NRL for Pathology for Cardiac Disease

Answer 33

Philippine Heart Center

Question 34

NRL for a. HIV/AIDS b. Hepatitis c. Syphilis

Answer 34

San Lazaro Hospital/STD-AIDS Central Cooperative Laboratory

Question 35

Valuable benchmarking tool

Answer 35

External quality assurance