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Clinical Chemistry Lecture MIDTERMS > Qual Control > Flashcards

Qual Control Flashcards

1
Q

involves the SYSTEMATIC MONITRING OF ANALYICAL PROCESSES to detect analytic errors that occur during analysis and to ultimately prevent the reporting of incorrect patient test results

A

QUALITY CONTROL

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2
Q

Application of multirule systems

A

WESTERGARD RULE

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3
Q

Plotting data

A

LEVEY JENNINGS CHART

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4
Q

“Setting” the analyzer to give correct results

A

CALIBRATION

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5
Q

Checking”
- If the analyzer is producing correct results

A

QUALITY CONTROL

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6
Q

Run along-side patient samples and results

A

QUALITY CONTROL

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7
Q

Run prior to QC manually

A

CALIBRATION

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8
Q

Refers to the substance or base from which the control material is prepared.

A

MATRIX

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9
Q

3 TYPES OF CONTROL MATERIALS

A

ASSAYED
UNASSAYED
HOME MADE OR IN HOUSE

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10
Q

Target value PREDETERMINED

A

ASSAYED

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11
Q
  • Commonly used in the laboratory
  • Manufacturer gives CONTROL MATERIAL AND RANGE for comparison
A

ASSAYED

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12
Q

● Target values not PREDETERMINED
● Full assay to be established

A

UNASSAYED

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13
Q

Manufacturer gives CONTROL MATERIAL W/O RANGE

A

UNASSAYED

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14
Q

● Pooled sera collected in the laboratory
● Full assay, validation needed
○ No manufacturer

A

HOME MADE OR INHOUSE

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15
Q

Describes the CLOSENESS of a test value to the actual/target/true valu

A

ACCURACY

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16
Q

ACCURACY can be measured in 3 ways

A

(RIC)

Recovery study
Interference method
Comparison of methods of study

17
Q

● Patient sample is added concentrated analyte of interest
● Accurate machine → INCREASED RESULT even if sample has other analytes present

A

Recovery study

18
Q

Interfering substances REFLECT/ABSORB light and REACT with reagents.
● Accurate Machine → Machine WON’T CHANGE RESULTS with the presence of interfering substances

A

INTERFERENCE STUDY

19
Q

Gold standard method

A

HPLC

20
Q

Accurate Machine → If lab result (recovery study) is CLOSE to gold standard (interference study) result

A

COMPARISON OF METHODS OF STUDY

21
Q

Degree of REPLICATION of data

A

PRECISION

22
Q

Ability of analytical methods to give REPEATED results on the same sample that agree with one another.

A

PRECISION

23
Q

Capacity to produce the SAME RESULTS ON ONE SAMPLE again and again when performed by the SAME individual using the SAME lot numbers on the SAME instruments..

A

REPEATABILITY/PRACTICABILITY

24
Q

Capacity of the method to produce the SAME RESULTS ON THE SAME SAMPLE again and again when performed by DIFFERENT individuals on DIFFERENT days using DIFFERENT sets of reagents.

A

REPRODUCIBILITY

25
Q

Ability of ANALYTICAL method
to measure the SMALLEST CONCENTRATION of the analyte of interest

A

ANALYTICAL SENSITIVITY

26
Q

Ability of an ANALYTICAL
method to measure ONLY the analyte of interest

A

ANALYTICAL SPECIFICITY

27
Q

Ability of the test to detect the proportion of individuals W/ THAT DISEASE who test POSITIVELY with the test

A

DIAGNOSTIC SENSITIVITY

28
Q

Ability of the test to detect
the proportion of individual W/O THE DISEASE who test NEGATIVELY for the disease

A

DIAGNOSTIC SPECIFICITY

29
Q

NRL for Dengue, Influenza, TB, and other Mycobacteria.

A

Research Institute for Tropical Medicine

30
Q

NRL for
- Anatomic Pathology for Pulmonary Disease
- Biochemistry, Clinical Chemistry

A

Lung Center of the Philippines

31
Q

NRL for

  • Hematology, Immunohematology
  • Immunopathology, Anatomic Pathology
A

National Kidney and Transplant Institute

32
Q

NRL for
- Environmental and Occupational Health
- Toxicology (drug testing)
- Micronutrient Assay (confirmatory test for
drug test)

A

East Avenue Medical Center

33
Q

NRL for Pathology for Cardiac Disease

A

Philippine Heart Center

34
Q

NRL for

a. HIV/AIDS
b. Hepatitis
c. Syphilis

A

San Lazaro Hospital/STD-AIDS Central Cooperative Laboratory

35
Q

Valuable benchmarking tool

A

External quality assurance

Clinical Chemistry Lecture MIDTERMS (5 decks)

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