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Flashcards in Quantitative Pharmacokinetics Deck (11):
1

Kinetic Order

Dependence of rate of a process on the exponent of the drug concentration

2

First order kinetics

[drug]^1 = [drug] So, rate is directly dependent on [drug] and a constant percent is lost per unit time. Michaelis-Menten kinetics
Examples: drug metabolism under normal circumstances and renal excretion behave this way

3

Zero order kinetics

[drug]^0 = 1 So, rate is independent of [drug] and a constant amount is lost per unit time. Examples: overdose and drug administration

4

Rate of drug input

f(D/T) where f=fractional absorption D=dose and T=time

5

Half-life

Time required for 50% clearance, only applies to first order processes. t1/2=(0.7 * Vd)/CL where CL is clearance.

6

Clearance

Predicts rate of elimination in relation to drug concentration CL=(Vd)(Ke) only for 1st order

7

Time course of drug effects

Immediate (may not be linearly proportional to concentration) Delayed (effected by distribution, tight binding, slow turnover of physiologic substance) Cumulative effects

8

Steady State

Plateau phase: Input rate = output rate
f(D/T)=(Css)(Vd)(Ke)

9

Loading Dose

Achieve steady state in one dose
LD=(Css)(Vd)

10

Maintenance Dose

MD=(CL)(Css)

11

Ke

=0.7/(t1/2)