Flashcards in Quantitative Pharmacokinetics Deck (11):

1

## Kinetic Order

### Dependence of rate of a process on the exponent of the drug concentration

2

## First order kinetics

###
[drug]^1 = [drug] So, rate is directly dependent on [drug] and a constant percent is lost per unit time. Michaelis-Menten kinetics

Examples: drug metabolism under normal circumstances and renal excretion behave this way

3

## Zero order kinetics

### [drug]^0 = 1 So, rate is independent of [drug] and a constant amount is lost per unit time. Examples: overdose and drug administration

4

## Rate of drug input

### f(D/T) where f=fractional absorption D=dose and T=time

5

## Half-life

### Time required for 50% clearance, only applies to first order processes. t1/2=(0.7 * Vd)/CL where CL is clearance.

6

## Clearance

### Predicts rate of elimination in relation to drug concentration CL=(Vd)(Ke) only for 1st order

7

## Time course of drug effects

### Immediate (may not be linearly proportional to concentration) Delayed (effected by distribution, tight binding, slow turnover of physiologic substance) Cumulative effects

8

## Steady State

###
Plateau phase: Input rate = output rate

f(D/T)=(Css)(Vd)(Ke)

9

## Loading Dose

###
Achieve steady state in one dose

LD=(Css)(Vd)

10

## Maintenance Dose

### MD=(CL)(Css)

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