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1 STEP UW Nephrology > Quick nephritic > Flashcards

Quick nephritic Flashcards

1
Q

triad of nephritic?

A

hypertension+hematuria+oliguria

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2
Q

Why hypertension?

A

due to retention of salt

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3
Q

how looks glomeruli?

A

hypercellular/inflamed glomeruli on biopsy

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4
Q

Acute poststreptococcal GN in what age?

A

most frequently seen in children 3-12y/o

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5
Q

Acute poststreptococcal GN after infection when occur?

A

~2-4 weeks after group A streptococcal infection

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6
Q

What infections on A streptococcus? 2

A

pharynx (1-2 sav) and skin (3-4sav)

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7
Q

Acute poststreptococcal GN. Result in children and adult?

A

in children resolves spontaneously;

in adults may progress to renal insufficiency.

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8
Q

Acute poststreptococcal GN. What type of hypersensitivity?

A

type III

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9
Q

Lab? What titers and C? Acute poststreptococcal GN

A

positive strep titers/serologies;

decr. C3 due to consumption.

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10
Q

LM - glomeruli enlarged and hypercellular

A

Acute poststreptococcal GN

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11
Q

IF - (starry sky) granular appearrance (lumpy-bumpy) due to IgG, IgM and C3 deposition along GMB and mesangium

A

Acute poststreptococcal GN

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12
Q

IF - starry sky?

A

Acute poststreptococcal GN

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13
Q

IF - lumpy bumpy

A

Acute poststreptococcal GN

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14
Q

IF - granular appearrance due to IgG, IgM and C3 deposition along GMB and mesangium

A

Acute poststreptococcal GN

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15
Q

EM - subepithelial IC deposits (humps)

A

Acute poststreptococcal GN

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16
Q

LM - crescent moon shape

A

Rapidly progressive (crescentic) GN

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17
Q

crescent moon shape consists of?

A

Fibrin and plasma proteins (eg C3b) with glomerular parietal cells, monocytes, macrophages

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18
Q

Rapidly progressive (crescentic) GN prognosis?

A

Poor prognosis, rapidly deteriorating renal function (days to weeks) [ESRD]

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19
Q

Rapidly progressive (crescentic) GN Age?

A

60-85y/o

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20
Q

What diseases results in Rapidly progressive (crescentic) GN pattern?

A

IF pattern

Linear: Goodpasture syndrome (anti-GBM disease)

Granular (immune complex RPGN):

a) Poststreptococcal GN
b) Diffuse proliferative glomerulonephritis (most common with SLE)

Negative (pauci-immune RPGN):

a) Granulomatosis with polyangiitis (wegener)
b) Microscopic polyangiitis
c) Eosinophilic granulomatosis with polyangiitis

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21
Q

Goodpasture syndrome (anti-GBM disease) IF pattern?

A 
Rapidly progressive (crescentic) GN
LINEAR
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22
Q

Poststreptococcal GN IF pattern?

A 
Rapidly progressive (crescentic) GN
Granular (immune complex RPGN)
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23
Q

Diffuse proliferative glomerulonephritis (most common with SLE) IF pattern?

A 
Rapidly progressive (crescentic) GN
Granular (immune complex RPGN)
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24
Q

Granulomatosis with polyangiitis IF pattern?

A 
Rapidly progressive (crescentic) GN
Negative (pauci-immune RPGN)
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25
Microscopic polyangiitis IF pattern?
``` Rapidly progressive (crescentic) GN Negative (pauci-immune RPGN) ```
26
Eosinophilic granulomatosis with polyangiitis IF pattern?
``` Rapidly progressive (crescentic) GN Negative (pauci-immune RPGN) ```
27
Linear IF pattern patho?
antibodies to GBM and alveolar basement membrane (anti-GBM disease)
28
Goodpasture manifestation and hypertensitivity?
hematuria/hemoptysis. Typer II. Treatment - plasmapheresis
29
Negative IF/Pauci-immune patho?
no Ig/C3 depositions
30
Granulomatosis with polyangiitis (wegener) kokie yra ANCA?
PR3-ANCA/c-ANCA
31
Microscopic polyangiitis kokie ANCA?
MPO-ANCA/p-ANCA
32
PR3-ANCA/c-ANCA
Granulomatosis with polyangiitis (wegener) kokie yra ANCA?
33
MPO-ANCA/p-ANCA
Microscopic polyangiitis kokie ANCA?
34
Microscopic polyangiitis vs Granulomatosis with polyangiitis (wegener)? microscopy
In Microscopic polyangiitis there are no granulomatous inflammation
35
Goodpasture against what collagen?
colagen IV
36
SLE most commonly cause what GN?
Diffusive proliferative GN
37
Diffusive proliferative GN crescent IF pattern?
Granular (immune complex RPGN):
38
LM - ''wire looping" of capillaries? aka Thickening of glomerular capillaries
Diffusive proliferative GN
39
IF - granular?
Diffusive proliferative GN
40
EM - suENDOTHELIAL and sometimes intramembranous IgG-base IC often with C3 deposition?
Diffusive proliferative GN
41
Diffusive proliferative GN what EM deposits?
suENDOTHELIAL and sometimes intramembranous IgG-base IC often with C3 deposition
42
lupus cause what nephrotic and what nephritic?
Nephrotic - membranous nephropathy | nephritic - diffuse proliferative GN
43
IgG+C3+C1q?
Diffusive proliferative GN
44
C3 in Diffusive proliferative GN?
decreased
45
what markers may be found in Diffusive proliferative GN?
ANA and anti-dsDNA - due to lupus. Because Diffusive proliferative GN often due to lupus.
46
Characterized by increased glomerular cellularity in more than half of the glomeruli?
Diffusive proliferative GN
47
Episodic hematuria concurently with respiratory of GI infections?
IgA nephropathy (Berger disease)
48
LM - mesangial proliferation?
IgA nephropathy (Berger disease)
49
IF - IgA based IC depostis in mesangium?
IgA nephropathy (Berger disease)
50
EM - mesangial IC deposits?
IgA nephropathy (Berger disease)
51
in what diseases the main location is mesangium?
IgA nephropathy (Berger disease) (mesangial deposits!)
52
when (days) manifest IgA nephropathy (Berger disease)?
2-3 days after mucus membrane infection
53
Most common type of idiopathic glomerulonephritis worldwide?
IgA nephropathy (Berger disease)
54
↑ Serum IgA?
IgA nephropathy (Berger disease)
55
Normal C3 complement levels?
IgA nephropathy (Berger disease)
56
C3 in postreptococcal?
decreased
57
IgA nephorpathy (berger). in kidney - IgA vasculitis (HSP)
.
58
Type IV hypersensitivity reaction?
Granulomatosis with polyangiitis (wegener)
59
Renal biopsy: segmental necrotizing glomerulonephritis?
Granulomatosis with polyangiitis (wegener)
60
Type II hypersensitivity reaction?
Goodpasture
61
Hemosiderin-filled macrophages in sputum | and Iron deficiency anemia?
Goodpasture
62
X-linked dominant disease?
Alport
63
mutation in gene coding type IV collagen?
Alport
64
eye problems (retinopathy and lens dislocation) in wgat disease?
alport
65
sensineural deafness in what disease?
alport
66
cant see cant pee cant hear a bee. what disease?
alport
67
EM - basket-weave?
alport
68
Severe disease typically manifests during adolescence?
alport
69
Most common type of hereditary nephritis?
alport
70
Persistent microhematuria with intermittent gross hematuria?
alport
71
mutation in type IV collagen how changes GBM?
mutation --> thinning and splitting of GBM (lamellated and basket-weave appearance)
72
what two GN manifest as both nephritic and nephrotic?
Diffuse proliferative and membranoproliferative GN
73
Type 1 MPGN mechanism?
IG-mediated
74
Type 2 MPGN mechanism?
Complement-mediated
75
Hepatitis B and C what membranoproliferative GN?
type 1
76
IF - subendothelial and mesangial IgG immune complex deposits with granular appearance?
Type 1 MPGN
77
Type 1 MPGN C3 level?
↓ Serum C3 complement levels
78
IF - Intramembranous C3 deposits (dense deposit disease) on basement membrane?
Type 2 MPGN
79
Type 2 MPGN C3 level?
↓ Serum C3 complement levels
80
Dense deposit disease? what is that?
Type 2 MPGN, because Intramembranous C3 deposits
81
Tram-track appearance?
both Type 1 and 2 MPGN
82
LM with H&E or PAS stain shows mesangial ingrowth, which leads to thickening and splitting of the glomerular basement membrane (tram-track appearance)?
both Type 1 and 2 MPGN
83
IgG against C3 convertase?
Type 2 MPGN
84
IgG against C3 convertase effect?
stabilizes C3 convertase --> persistent complement activation --> decr. C3 levels.
85
What is C3NeF?
C3 nephritic factor (IgG against C3 convertase)
86
characterized by deposition of antibodies between podocytes and the basal membrane?
MPGN

1 STEP UW Nephrology (14 decks)

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