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Flashcards in Quickies Deck (75)
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1

Adverse effects in all organ systems

Adesleukin
(interferon - renal)

2

Adesleukin

affects every organ system
capillary leak syndrome
Melanoma
IL-2 agonist

3

Pregnancy Cat D

end w/ -ib

4

Imiquimod

localized BCC and AK
Immunostimulant (TLR-7 and 8; Th1; negative effect on GLI)
Can compromise birth control
photosensitivity

5

interferon

Melanoma immunotherapy
Contraindicated in autoimmune, cardiac dz, depression;
Flu-like, blood

6

Blood dyscrasias

Interferon
Sorafenib
Trametinib

7

Iplilimumb (MMM)

Melanoma immunotherapy
Immunostimulate of T Cells (inhibits CTLA-4)
Many unique contraindications
mild-->severe (toxic epidermal necrolysis)
Endocrinopathies

8

SJS

all three signal transduction inhibitor melanoma therapies

9

SOrafenib

SO many targets (VEGF, PDGFR, RAF kinase)
SO much bleeding
SOre hands and feet (hand-foot syndrome)
Melanoma signal transduction inhibitor

10

Trametinib

Melanoma signal transduction inhibitor
Reversible MEK inhibitor
BRAF V600(K) mutations
Requires genetic testing
EYE!!

11

Trichloroacetic acid

AK
burning, inflammation, localized tenderness

12

VemuRAFenib

Melanoma signal transdction inhibitor
BRAF inhibitor
SHOULD NOT be used in wild-type--> secondary tumors via paradoxical
Requires genetic testing
EYE!!

13

VisSMOdegib

SMO inhibitor
blocks SMOoth moves by eggs and sperm (male and female teratogen)

14

BCC

localized=imiquimod
advanced= cisplatin and cyclo

15

SCC

early=surgery/radiation
Late=Cisplatin

16

Melanoma

2 - 3 - and 3
Carmustine and Dacarbazine
Adesleukin, Interferon, Ipilimumab
Sorafenib, Trametinib, Vemurafenib

17

Acyclovir

zoster and chicken pox
classic viral DNA polymerase (dGTP)
prevents chain elongation
neurotoxicity

18

Cidofovir

deoxyCytosine...viral DNA polymerase
POX, HHV-6 and 7
NEPHROTOXICITY (probenecid and hydration)

19

Famciclovir

Zoster
classic viral DNA polymerase (dGTP)
Best tolerated

20

Foscarnet

HHV-6
Unusual MOA
prevents chain elongation
Electrolyte imbalance

21

Ganicyclovir

HHV-6 and 8
classic viral DNA polymerase (dGTP)
Blood penias

22

Valacyclovir

same as acyclovir (pro-drug)

23

Acitretin

Topical Psoriasis
RAR retinoid
Similar to Vitamin A toxicity (dry skin; nosebleed; conjunctivitis; hair loss…); mucocutaneous and muscoskeletal symptoms; hyperlipidemia
Teratogen

24

Tazorotene

Psoriasis AND acne
RAR retinoid
Teratogen

25

Adalimumab
Enterocept
Infliximab

Psoriasis and autoimmunes
TNF-a
Don't use concurrent vaccines/immunosuppression
BBW infections and neoplasia

26

Infliximab

extra problems since chimeric

27

Ustukinumab

(p)40 - (Th)17 = (IL-)23 + (Th)1 = 24 / 2 = (IL-) 12
Psoriasis
don't use w/ live virus vaccine
infections and neoplasias and anaphylaxis

28

all mabs...

worry about infections and neoplasia

29

Calcipotrene

Topical psoriasis
Retinoid RXR receptors
Vitamin D
Hypercalcemia and Hypercalciuria!!!

30

Topical application

everything but mabs