Quickies Flashcards Preview

Question 1

1

Adverse effects in all organ systems

Answer

Adesleukin
(interferon - renal)

Question 2

2

Adesleukin

Answer

affects every organ system
capillary leak syndrome
Melanoma
IL-2 agonist

Question 3

3

Pregnancy Cat D

Answer

end w/ -ib

Question 4

4

Imiquimod

Answer

localized BCC and AK
Immunostimulant (TLR-7 and 8; Th1; negative effect on GLI)
Can compromise birth control
photosensitivity

Question 5

5

interferon

Answer

Melanoma immunotherapy
Contraindicated in autoimmune, cardiac dz, depression;
Flu-like, blood

Question 6

6

Blood dyscrasias

Answer

Interferon
Sorafenib
Trametinib

Question 7

7

Iplilimumb (MMM)

Answer

Melanoma immunotherapy
Immunostimulate of T Cells (inhibits CTLA-4)
Many unique contraindications
mild-->severe (toxic epidermal necrolysis)
Endocrinopathies

Question 8

8

SJS

Answer

all three signal transduction inhibitor melanoma therapies

Question 9

9

SOrafenib

Answer

SO many targets (VEGF, PDGFR, RAF kinase)
SO much bleeding
SOre hands and feet (hand-foot syndrome)
Melanoma signal transduction inhibitor

Question 10

10

Trametinib

Answer

Melanoma signal transduction inhibitor
Reversible MEK inhibitor
BRAF V600(K) mutations
Requires genetic testing
EYE!!

Question 11

11

Trichloroacetic acid

Answer

AK
burning, inflammation, localized tenderness

Question 12

12

VemuRAFenib

Answer

Melanoma signal transdction inhibitor
BRAF inhibitor
SHOULD NOT be used in wild-type--> secondary tumors via paradoxical
Requires genetic testing
EYE!!

Question 13

13

VisSMOdegib

Answer

SMO inhibitor
blocks SMOoth moves by eggs and sperm (male and female teratogen)

Question 14

14

BCC

Answer

localized=imiquimod
advanced= cisplatin and cyclo

Question 15

15

SCC

Answer

early=surgery/radiation
Late=Cisplatin

Question 16

16

Melanoma

Answer

2 - 3 - and 3
Carmustine and Dacarbazine
Adesleukin, Interferon, Ipilimumab
Sorafenib, Trametinib, Vemurafenib

Question 17

17

Acyclovir

Answer

zoster and chicken pox
classic viral DNA polymerase (dGTP)
prevents chain elongation
neurotoxicity

Question 18

18

Cidofovir

Answer

deoxyCytosine...viral DNA polymerase
POX, HHV-6 and 7
NEPHROTOXICITY (probenecid and hydration)

Question 19

19

Famciclovir

Answer

Zoster
classic viral DNA polymerase (dGTP)
Best tolerated

Question 20

20

Foscarnet

Answer

HHV-6
Unusual MOA
prevents chain elongation
Electrolyte imbalance

Question 21

21

Ganicyclovir

Answer

HHV-6 and 8
classic viral DNA polymerase (dGTP)
Blood penias

Question 22

22

Valacyclovir

Answer

same as acyclovir (pro-drug)

Question 23

23

Acitretin

Answer

Topical Psoriasis
RAR retinoid
Similar to Vitamin A toxicity (dry skin; nosebleed; conjunctivitis; hair loss…); mucocutaneous and muscoskeletal symptoms; hyperlipidemia
Teratogen

Question 24

24

Tazorotene

Answer

Psoriasis AND acne
RAR retinoid
Teratogen

Question 25

25

Adalimumab
Enterocept
Infliximab

Answer

Psoriasis and autoimmunes
TNF-a
Don't use concurrent vaccines/immunosuppression
BBW infections and neoplasia

Question 26

26

Infliximab

Answer

extra problems since chimeric

Question 27

27

Ustukinumab

Answer

(p)40 - (Th)17 = (IL-)23 + (Th)1 = 24 / 2 = (IL-) 12
Psoriasis
don't use w/ live virus vaccine
infections and neoplasias and anaphylaxis

Question 28

28

all mabs...

Answer

worry about infections and neoplasia

Question 29

29

Calcipotrene

Answer

Topical psoriasis
Retinoid RXR receptors
Vitamin D
Hypercalcemia and Hypercalciuria!!!

Question 30

30

Topical application

Answer

everything but mabs

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DERM Pharm > Quickies > Flashcards

Adverse effects in all organ systems

Adesleukin(interferon - renal)

Adesleukin

affects every organ systemcapillary leak syndromeMelanomaIL-2 agonist

Pregnancy Cat D

end w/ -ib

Imiquimod

localized BCC and AKImmunostimulant (TLR-7 and 8; Th1; negative effect on GLI)Can compromise birth controlphotosensitivity

interferon

Melanoma immunotherapyContraindicated in autoimmune, cardiac dz, depression;Flu-like, blood

Blood dyscrasias

InterferonSorafenibTrametinib

Iplilimumb (MMM)

Melanoma immunotherapyImmunostimulate of T Cells (inhibits CTLA-4)Many unique contraindicationsmild-->severe (toxic epidermal necrolysis)Endocrinopathies

SJS

all three signal transduction inhibitor melanoma therapies

SOrafenib

SO many targets (VEGF, PDGFR, RAF kinase)SO much bleedingSOre hands and feet (hand-foot syndrome)Melanoma signal transduction inhibitor

Trametinib

Melanoma signal transduction inhibitorReversible MEK inhibitorBRAF V600(K) mutationsRequires genetic testingEYE!!

Trichloroacetic acid

AKburning, inflammation, localized tenderness

VemuRAFenib

Melanoma signal transdction inhibitorBRAF inhibitorSHOULD NOT be used in wild-type--> secondary tumors via paradoxicalRequires genetic testingEYE!!

VisSMOdegib

SMO inhibitorblocks SMOoth moves by eggs and sperm (male and female teratogen)

BCC

localized=imiquimodadvanced= cisplatin and cyclo

SCC

early=surgery/radiationLate=Cisplatin