QUINOLONES

Question 1

Indications for ciprofloxacin

Answer 1

Skin and soft tissue infections
Nosocomial pneumonia
Infectious diarrhea
Typhoid fever
Lower respiratory tract infections
Infections in cystic fibrosis
Bone and joint infections
UTI
Diabetic foot infection
Gonorrhea
Acute sinusitis
Intraabdominal infections
Acute and Chronic Bacterial Prostatitis
Plague

Question 2

Dosing ciprofloxacin in adults

Answer 2

500mg PO 12 hourly or 400mg IV infusion over 60 minutes for mild/moderate infections

750mg PO 12 hourly or 400mg IV infusion over 60 minutes for severe infections

Question 3

Which CYP450 is inhibited by Ciprofloxacin

Answer 3

CYPA 1A2

Question 4

Drugs that ciprofloxacin reduce their metabolism

Answer 4

Theophylline
Tizanidine
Clozapine
Olanzapine
Zolpidem

Question 5

Adverse effects of ciprofloxacin

Answer 5

Peripheral neuropathy
Tendinitis
Tendon rupture
CNS effects
Photosensitivity
GIT disturbances
QT prolongation
Hyper or hypoglycemia

Question 6

CNS adverse effects of fluoroquinolones

Answer 6

Toxic psychosis
Convulsions
Increases ICP
Lower seizure threshold

Question 7

Contraindications of ciprofloxacin

Answer 7

Myasthenia gravis
Documented hypersensitivity
Coadministration with tizanidine
Caution in pregnancy and lactation

Question 8

Dose adjustments for ciprofloxacin

Answer 8

Adjust dose when eGFR< 50
Use with caution in hepatic impairment