Quiz 1 Flashcards

(55 cards)

1
Q

biology is the study of…

A

living things

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

mechanics is the study of…

A

motions and the applied loads that cause them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

biomechanics is thus defined as the study of…

A

the motions experienced by living things in response to applied loads

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

da Vinci was interested in…

A

human flight (he studied how birds fly), an early example of mankind attempting to base the design of engineered systems on nature’s way of doing the same thing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

mankind attempting to base the design of engineered systems on nature’s way of doing the same thing is called…

A

bionics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Galileo was interested in…

A

bone strength, and how the structure of bones contributes to their strength

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Galileo (mistakenly) proposed that bones could be _________, which would improve the strength-to-weight ratio

A

hollow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Julius Wolff put forth the idea (and eventually the Law) of…

A

form follows function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

following Wolff’s ideas, Wilhelm Roux put forth the concept of…

A

a quantitative self-regulating mechanism that results in functional adaptation of living things

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

list some reasons the 1960s were big for biomechanics

A

development of the computer, space race necessitating research into how bodies would react in space, advancement of numerical methods like FEM, birth of modern biology following identification of protein and DNA structures in the 50s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

compared to classical physics, modern physics enables important diagnostic tools such as…

A

CAT scans and MRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

statistical mechanics attempt to describe the ________ behavior of the ___________

A

statistical (mean), individual molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

continuum mechanics consider a _______________ behavior that is independent of the _________________

A

volume-averaged mean, individual molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

the continuum assumption is reasonable when characteristic length of the microstructure / characteristic length of the physical problem of interest is (&laquo_space;or&raquo_space;) 1

A

&laquo_space;1 (basically, when the scale of the overall problem is way bigger than the scale of the individual particles)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

“cell,” a term coined by ______, comes from the Latin cellulea, meaning ____________

A

coined by Hook, meaning “little rooms” (that’s so cute)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

primary function of the nucleus is…

A

to archive and replicate genetic code as needed to direct cellular activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

all cells in a given organism contain the same ____________, but do not all ________ the same genes

A

genotype, express

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

the genes which are expressed determine a cell’s…

A

phenotype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

the mitochondria…

A

provides a cell with energy by oxidizing foodstuffs to make ATP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

the rough ER…

A

synthesizes proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

ribosomes…

A

carry RNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

the smooth ER…

A

packages proteins and synthesizes lipids and steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

the Golgi apparatus…

A

synthesizes polysaccharides and modifies, packages, and transports various macromolecules

24
Q

lysosomes, with an internal pH of 5, …

A

digest proteins, carbs, and fats with enzymes like nucleases, proteases, and lipases

25
peroxisomes...
generate and degrade hydrogen peroxide (a cytotoxin) and assist in detoxifying other compounds
26
the cytoplasm includes...
all organelles other than the nucleus, the cytoskeleton, and the cytosol
27
the cytosol is about ______ of the total cell volume and consists primarily of _______
1/2, water
28
the cytoskeleton is made up of three classes of filamentous proteins that collectively give the cell much of its internal structure. list the three types of proteins
actin, microtubules, and intermediate filaments (vimentin, lamins, and keratins)
29
what is the additional intracellular constituent present in striated muscle?
the myofibril
30
myofibrils are made up of...
sarcomeres
31
sarcomeres consist of...
thin (actin) and thick (myosin) filaments that attach, detach, and reattach to each other to produce muscle contraction
32
integrins are transmembrane proteins that bind to other proteins - they consist of...
two noncovalently associated glycoproteins, called alpha and beta units
33
what are the three types of cell interconnections?
occluding (or tight), anchoring, and communicating (or gap)
34
what do growth factors do?
GFs are special proteins that bind to specific receptors on the membrane and encourage cell division
35
common classes of growth factors are...
platelet-derived (PDGFs), fibroblast (FGFs), and transforming (TGFs)
36
____________ and __________ can increase the secretion of growth factors
mechanical stresses and injuries
37
the ECM consists primarily of...
proteins, glycosaminoglycans (GAGs), and bound and unbound water
38
GAGs are often bound to...
protein cores, forming proteoglycans
39
_________ is the most abundant protein in the body (25-30%)
collagen
40
collagen types I and III...
form fibers and provide structural support in tension, abundant in ligaments, tendons, and bones
41
collagen type II...
occurs as fibrils, found largely in cartilage
42
collagen type IV...
forms as a porous network (basement membrane) that acts as a scaffold for epithelial and endothelial cells, has extensive disulfide bonds
43
collagen types V and VI...
associate with smooth muscle cells
44
collagen type VIII...
associates with endothelial cells
45
the collagen molecule consists of...
3 polypeptide alpha chains, organized into a central triple-helix motif repeating AA residues (G-X-Y)
46
what type of cells synthesize type IV collagen?
endothelial
47
what type of cells synthesize types I and III collagen?
fibroblasts and smooth muscle cells
48
the degree of cross-linking (increases/decreases) with age, resulting in...
increases, resulting in stiffening
49
the primary responsibility of fibroblasts is...
regulation of the collagen-rich ECM
50
cells that can change their gene expression in response to mechanical stimuli are called...
mechanocytes
51
what two junctions connect cells to the ECM?
hemidesmosomes and focal adhesions
52
what two junctions connect cells to cells?
desmosomes and adherent junctions
53
ligaments attach...
bone to bone (guides movement)
54
tendons attach..
bone to muscle (transmits force)
55
the most common type of cartilage is...
hyaline (lots of bound water)