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Flashcards in Quiz 1 Deck (148):
1

Soccer Ball Chromatin

CLL

2

infection
Necrosis
Drugs

Neutophilia

3

Chemotherapy
Immune destruction
Septic Shock

Neutopenia

4

Type 1 hypersensitivity
Parasites
HYPOcortisolism

Eosinophilia

5

Hypercellular BM with effective hematopoiesis

Myeloproliferative neoplasms

6

BCR-ABL fusion
(increase tyrosine kinase)

CML
Chronic Myelogenous Leukemia

7

JAK2 gene mutation in 100% of patients

PV
Polycythemia Vera

8

Teardrop cells

PMF
Primary myelofibrosis

9

proliferation of megakaryocytes

ET
Essential thrombocytopenia

10

t(9;22)

Philadelphia chromosome

11

t(9:22)
Philadelphia chromosome

CML
and B-Cell ALL (bad)

12

Decresed EPO
Increased RBC mass

PV
Polycythemia Vera

13

Atypical megakaryocytes

PMF
primary myelofibrosis

14

Atypical platelet morphology

ET
Essential thrombocytopenia

15

Basophilia associated MPN

CML

16

MPN treated with phlebotomy

PV
Polycythemia Vera

17

Treated with Alkylating agents

ET
Essential Thrombocytopenia
(It lowers platelet counts)

18

MPN treated with Gleevec (imatinib)

CML

19

JAK2 in ~50%

PMF and ET

20

Monosomy 7

MDS
Myelodysplastic syndrome

21

treat with hypomethylating agents

MDS myelodysplastic sydrome
(want to increase transcription due to lost chromosome)

22

t(8;21)
inv(16)
t(15;17)

Favorable AML

23

Auer Rods

AML

24

t(15;17)
treatment

Treat with ATRA (all-trans retinoic acid)

25

t(15;17) disease

Acute Promyelocytic leukemia
subset of AML

26

male child with >20% blasts

ALL

27

AML markers

CD34
CD117 (c-kit)

28

Treatment for MDS

Supportive
Hypomethylating agents
Allogenic Stem cell transfer

29

MPO and NSE stain

AML (for blasts)

30

Adults with >20% blasts

AML

31

Polyclonal expansion of lymphocytes

Reactive lymphocytosis

32

Monoclonal expansion of lymphocytes

Neoplastic Lymphocytosis

33

CD34(+)
TdT(+)
CD10(+)
CD19(+)
CD20(-)

B-Cell ALL

34

young male with Thymic/mediastinal mass

T-cell ALL

35

Good prognosis for B-Cell ALL

HYPERploidy (>50)
t(12;21)

36

Bad prognosis for B-cell ALL

HYPOpoloidy
Philadelphia chomosome t(9;22)

37

T-Cell ALL markers

CD3
CD4
CD8
TdT

38

B cell and T cell pathogenisis

Aggressive

39

CD5(+) and CD23(+)

CLL
Chronic Lymphocytic Leukemia

40

Hairy projections

Hairy cell Leukemia

41

B-Cell ALL demographic

Children

42

Mature B-cell Neoplasms

CLL and Hairy cell

43

CD11c(+)
CD22(+)
CD19(+)
CD20(+)

Hairy cell

44

Flower cells

Adult T-cell leukemia

45

Cerebriform nuclei

Mycosis fungoides/Sezary Syndrome

46

Mature B-cell Neoplasm pathogenisis

Indolent
(CLL and Hairy cell)

47

HTLV-1 Provirus
Endemic region

Japan, West Africa, Carribean

48

HTLV-1 disease

Adult T-cell
(flower cells)

49

CD4(+)
CD25(+)
skin lesions
hypercalcemia

Adult-T cell

50

Demographic for Mature T-cell Neoplasms

Adults
(Adult T-cell, Large Granular, Mycosis fungoides)

51

Pathogenisis Adult T-cell Leukemia

Agressive

52

Pathogenisis T cell Large Granular Lymphocytic Leukemia

Indolent

53

T helper cells leukemia

Adult T cell

54

Cytotoxic T cell leukemia

Large Granular lymphocytic leukemia (CD8)

55

CRAB
hyperCalcemia
Renal insufficiency
Anemia
Bone disease

Multiple myeloma
(plasma cell neoplasm)

56

Demographic for Multiple myeloma

AA retired men

57

Benign plasma cell proliferation

MGUS(monoclonal gammopathy of undetermined significance)

58

Bence Jones

In urine of Multiple Myeloma

59

Clonal plasma cells
M-Protein
End organ damage

Multiple myeloma

60

Congo Red

Amyloidosis

61

BCL-2IgH fusion

Follicular Lymphoma

62

t(11;14)

Mantle cell lymphoma

63

t(14;18)

Follicular lymphoma

64

EBV associated lymphadenopathy

Burkitt Lymphoma

65

MALT1-IAP2 Fusion

MALToma
Extranodal marginal zone lymphoma

66

Cyclin D1-IgH fusion

Mantle cell Lymphoma

67

Retroperitoneal involement

Follicular lymphoma

68

Diffuse lesions pathogenisis

Aggressive
Diffuse Large B cell
Burkitt lymphoma

69

Associated with H.pylori and Hashimotos

MALToma
Extranodal marginal zone lymphoma

70

Generalized lymphadenopathy

Follicular lymphoma

71

Follicular can transform to_____

Diffuse large B cell is the majority
Burkitt lymphoma

72

All mature B cell lymphomas are positive for ______

CD19
CD20

73

CD5(-)
CD10(+)

Follicular

74

CD5(+)
CD10(-)
CD23(-)

Mantle cell

75

CD5(+)
CD23(+)

CLL

76

CD5(-)
CD10(-)

MALToma

77

c-Myc

Burkitt Lymphoma

78

T(8;14)
t(2;8)
t(8;22)
A lot of 8s

Burkitt Lymphoma

79

Burkitt lymphoma demographic

Adolescents

80

Cytotoxic T cell Lymphoma

Anaplastic Large cell lymphoma

81

Helper T cell lymphoma

Peripheral T cell lymphoma

82

EBV assosiated mature T cell lymphoma

Extranodal NK/T cell lymphoma

83

Pathogenisis of Mature T cell lymphomas

Aggressive

84

Children with mature t-cell lymphoma

Anaplastic large cell lymphoma

85

ALK rearrangement
(tyrosine Kinase)

Anaplastic Large cell lymphoma

86

sinonasal extra nodal destructive masses

Extranodal NK/T cell lymphoma

87

Reed Sternberg Cells

Classical Hodgkin Lymphoma

88

Mediastinum lymphoma

Classical Hodgkin

89

Contiguous spread

Classical Hodgkin

90

Axillary lymphoma

Nodular Hodgkin
(NLPHL)

91

Young Hodgkin patient

Classical

92

CD15(+)
CD30(+)
multiple of 15
CD20(-) odd
CD45(-)

Classical

93

CD20(+)
CD45(+)
CD15(-)
CD30(-)

NLPHL
Nodular Hodgkin

94

Popcorn cells

NLPHL
Nodular Hodgkins

95

T cell Markers

CD1a-8
Single digit

96

B-cell markers

CD19-CD-22

97

Generic Myeloid markers

CD13, CD15, CD33, CD117 (c-kit)

98

Megakaryocyte markers

CD41
CD61

99

Monocyte markers

CD14

100

TdT

ALL
Immaturity marker

101

CD34

Blast marker in AML and ALL

102

CD117

AML blast marker

103

CD1a

T-cell immaturity marker

104

where does blood form before the 5th month

Yolk sac then liver

105

CD15

Granulocytes

106

CD45(-) myeloid lineage cells

Eythroid
Megakaryocyte

107

EPO

Erythopoiesis
made in kidney

108

Starry Sky

Burkitt Lymphoma

109

Thrombopoietin

Stimulate megakaryocytes to produce platelets

110

G-CSF

stimulate granulocytes (neutrophil)

111

M-CSG

stimulate monocytes (macrophage)

112

All royal blue large cell

Proerythroblast

113

Large blue cell with a crescent of light blue cytoplasm

Myeloblast

114

loss of nucleus

orthochromatic
Normoblast

115

Small blue streaks in smaller red cell

Reticulocyte

116

changing from blue to red

Polychromatic erythroblast

117

kidney bean indentation

Metamyelocyte

118

Amorphic nucleus

Band

119

Primary granule formation

Promyelocyte

120

Specific granule formation

myelocyte

121

huge cell bigger than a blast

megakaryocyte

122

whopping cough reaction

increase lymphocytes

123

fungal/parasite reaction

Eosinophilia

124

Appendicitis

Neutrophilia

125

FLT3 in t(15;17)

AML
tryrosine kinase
Poor prognosis

126

NPM1 in t(15;17)

AML
nucleocytoplasmic shuffling protein
Favorable prognosis

127

Tennis racket

Langerhans cell Histocytic neoplasm

128

Hand-Schuller-Christian triad

in Langerhans cell neoplasm
Bone Defect
Diabetes Insipidus
Exophthalmos

129

Associated with Rheumatoid and high Ferritin levels

HLH
Hemophagocytic lymphohistocytosis

130

3 regions of hypervariablility

CDR1,2,3

131

Heavy chain components

D to J to V to C

132

Light chain components

V to J to C

133

Junctional diversity

removal or addition of nucleotides

134

Allelic exclusion

maternal rearranges first
if successful. paternal is not expressed.
Only Maternal OR Paternal expressed

135

positive selection

weak self

136

Neg selection

strong self recognition

137

death via neglect

no self recognition

138

pancytopenia in mature B-cell leukemia

Hairy cell

139

Rheumatoid
Eosinophilic granules
CD 8

T-cell Large granular Lymphocytic leukemia

140

no plasma cells in bone marrow
80% upper respiratory

Plasmacytoma

141

Waldenstrom macroglobulinemia

Lymphoblastic lymphoma
Visual impairment
Raynauds

142

peripheral follicles

B-cells

143

Paracortex in medulla

T cells and macrophage

144

High endothelial venules

lymphocyte homing receptors

145

Primary follicle

Naive B cell

146

Secondary B follicle

lighter zone surrounded my dark mantle zone
B cells become activated

147

tingible body macrophages

in germinal centers
stars in 'starry sky' of burkitt lymphoma

148

Gout
Ruddy Face

PV