Quiz 1 Flashcards
(148 cards)
1
Q
Soccer Ball Chromatin
A
CLL
2
Q
infection
Necrosis
Drugs
A
Neutophilia
3
Q
Chemotherapy
Immune destruction
Septic Shock
A
Neutopenia
4
Q
Type 1 hypersensitivity
Parasites
HYPOcortisolism
A
Eosinophilia
5
Q
Hypercellular BM with effective hematopoiesis
A
Myeloproliferative neoplasms
6
Q
BCR-ABL fusion
increase tyrosine kinase
A
CML
Chronic Myelogenous Leukemia
7
Q
JAK2 gene mutation in 100% of patients
A
PV
Polycythemia Vera
8
Q
Teardrop cells
A
PMF
Primary myelofibrosis
9
Q
proliferation of megakaryocytes
A
ET
Essential thrombocytopenia
10
Q
t(9;22)
A
Philadelphia chromosome
11
Q
t(9:22)
Philadelphia chromosome
A
CML
and B-Cell ALL (bad)
12
Q
Decresed EPO
Increased RBC mass
A
PV
Polycythemia Vera
13
Q
Atypical megakaryocytes
A
PMF
primary myelofibrosis
14
Q
Atypical platelet morphology
A
ET
Essential thrombocytopenia
15
Q
Basophilia associated MPN
A
CML
16
Q
MPN treated with phlebotomy
A
PV
Polycythemia Vera
17
Q
Treated with Alkylating agents
A
ET
Essential Thrombocytopenia
(It lowers platelet counts)
18
Q
MPN treated with Gleevec (imatinib)
A
CML
19
Q
JAK2 in ~50%
A
PMF and ET
20
Q
Monosomy 7
A
MDS
Myelodysplastic syndrome
21
Q
treat with hypomethylating agents
A
MDS myelodysplastic sydrome
want to increase transcription due to lost chromosome
22
Q
t(8;21)
inv(16)
t(15;17)
A
Favorable AML
23
Q
Auer Rods
A
AML
24
Q
t(15;17)
treatment
A
Treat with ATRA (all-trans retinoic acid)
25
t(15;17) disease
Acute Promyelocytic leukemia
| subset of AML
26
male child with >20% blasts
ALL
27
AML markers
CD34
| CD117 (c-kit)
28
Treatment for MDS
Supportive
Hypomethylating agents
Allogenic Stem cell transfer
29
MPO and NSE stain
AML (for blasts)
30
Adults with >20% blasts
AML
31
Polyclonal expansion of lymphocytes
Reactive lymphocytosis
32
Monoclonal expansion of lymphocytes
Neoplastic Lymphocytosis
33
```
CD34(+)
TdT(+)
CD10(+)
CD19(+)
CD20(-)
```
B-Cell ALL
34
young male with Thymic/mediastinal mass
T-cell ALL
35
Good prognosis for B-Cell ALL
HYPERploidy (>50)
| t(12;21)
36
Bad prognosis for B-cell ALL
HYPOpoloidy
| Philadelphia chomosome t(9;22)
37
T-Cell ALL markers
CD3
CD4
CD8
TdT
38
B cell and T cell pathogenisis
Aggressive
39
CD5(+) and CD23(+)
CLL
| Chronic Lymphocytic Leukemia
40
Hairy projections
Hairy cell Leukemia
41
B-Cell ALL demographic
Children
42
Mature B-cell Neoplasms
CLL and Hairy cell
43
CD11c(+)
CD22(+)
CD19(+)
CD20(+)
Hairy cell
44
Flower cells
Adult T-cell leukemia
45
Cerebriform nuclei
Mycosis fungoides/Sezary Syndrome
46
Mature B-cell Neoplasm pathogenisis
Indolent
| CLL and Hairy cell
47
HTLV-1 Provirus
| Endemic region
Japan, West Africa, Carribean
48
HTLV-1 disease
Adult T-cell
| flower cells
49
CD4(+)
CD25(+)
skin lesions
hypercalcemia
Adult-T cell
50
Demographic for Mature T-cell Neoplasms
Adults
| Adult T-cell, Large Granular, Mycosis fungoides
51
Pathogenisis Adult T-cell Leukemia
Agressive
52
Pathogenisis T cell Large Granular Lymphocytic Leukemia
Indolent
53
T helper cells leukemia
Adult T cell
54
Cytotoxic T cell leukemia
Large Granular lymphocytic leukemia (CD8)
55
```
CRAB
hyperCalcemia
Renal insufficiency
Anemia
Bone disease
```
Multiple myeloma
| plasma cell neoplasm
56
Demographic for Multiple myeloma
AA retired men
57
Benign plasma cell proliferation
MGUS(monoclonal gammopathy of undetermined significance)
58
Bence Jones
In urine of Multiple Myeloma
59
Clonal plasma cells
M-Protein
End organ damage
Multiple myeloma
60
Congo Red
Amyloidosis
61
BCL-2IgH fusion
Follicular Lymphoma
62
t(11;14)
Mantle cell lymphoma
63
t(14;18)
Follicular lymphoma
64
EBV associated lymphadenopathy
Burkitt Lymphoma
65
MALT1-IAP2 Fusion
MALToma
| Extranodal marginal zone lymphoma
66
Cyclin D1-IgH fusion
Mantle cell Lymphoma
67
Retroperitoneal involement
Follicular lymphoma
68
Diffuse lesions pathogenisis
Aggressive
Diffuse Large B cell
Burkitt lymphoma
69
Associated with H.pylori and Hashimotos
MALToma
| Extranodal marginal zone lymphoma
70
Generalized lymphadenopathy
Follicular lymphoma
71
Follicular can transform to_____
Diffuse large B cell is the majority
| Burkitt lymphoma
72
All mature B cell lymphomas are positive for ______
CD19
| CD20
73
CD5(-)
| CD10(+)
Follicular
74
CD5(+)
CD10(-)
CD23(-)
Mantle cell
75
CD5(+)
| CD23(+)
CLL
76
CD5(-)
| CD10(-)
MALToma
77
c-Myc
Burkitt Lymphoma
78
T(8;14)
t(2;8)
t(8;22)
A lot of 8s
Burkitt Lymphoma
79
Burkitt lymphoma demographic
Adolescents
80
Cytotoxic T cell Lymphoma
Anaplastic Large cell lymphoma
81
Helper T cell lymphoma
Peripheral T cell lymphoma
82
EBV assosiated mature T cell lymphoma
Extranodal NK/T cell lymphoma
83
Pathogenisis of Mature T cell lymphomas
Aggressive
84
Children with mature t-cell lymphoma
Anaplastic large cell lymphoma
85
```
ALK rearrangement
(tyrosine Kinase)
```
Anaplastic Large cell lymphoma
86
sinonasal extra nodal destructive masses
Extranodal NK/T cell lymphoma
87
Reed Sternberg Cells
Classical Hodgkin Lymphoma
88
Mediastinum lymphoma
Classical Hodgkin
89
Contiguous spread
Classical Hodgkin
90
Axillary lymphoma
Nodular Hodgkin
| NLPHL
91
Young Hodgkin patient
Classical
92
```
CD15(+)
CD30(+)
multiple of 15
CD20(-) odd
CD45(-)
```
Classical
93
CD20(+)
CD45(+)
CD15(-)
CD30(-)
NLPHL
| Nodular Hodgkin
94
Popcorn cells
NLPHL
| Nodular Hodgkins
95
T cell Markers
CD1a-8
| Single digit
96
B-cell markers
CD19-CD-22
97
Generic Myeloid markers
CD13, CD15, CD33, CD117 (c-kit)
98
Megakaryocyte markers
CD41
| CD61
99
Monocyte markers
CD14
100
TdT
ALL
| Immaturity marker
101
CD34
Blast marker in AML and ALL
102
CD117
AML blast marker
103
CD1a
T-cell immaturity marker
104
where does blood form before the 5th month
Yolk sac then liver
105
CD15
Granulocytes
106
CD45(-) myeloid lineage cells
Eythroid
| Megakaryocyte
107
EPO
Erythopoiesis
| made in kidney
108
Starry Sky
Burkitt Lymphoma
109
Thrombopoietin
Stimulate megakaryocytes to produce platelets
110
G-CSF
stimulate granulocytes (neutrophil)
111
M-CSG
stimulate monocytes (macrophage)
112
All royal blue large cell
Proerythroblast
113
Large blue cell with a crescent of light blue cytoplasm
Myeloblast
114
loss of nucleus
orthochromatic
| Normoblast
115
Small blue streaks in smaller red cell
Reticulocyte
116
changing from blue to red
Polychromatic erythroblast
117
kidney bean indentation
Metamyelocyte
118
Amorphic nucleus
Band
119
Primary granule formation
Promyelocyte
120
Specific granule formation
myelocyte
121
huge cell bigger than a blast
megakaryocyte
122
whopping cough reaction
increase lymphocytes
123
fungal/parasite reaction
Eosinophilia
124
Appendicitis
Neutrophilia
125
FLT3 in t(15;17)
AML
tryrosine kinase
Poor prognosis
126
NPM1 in t(15;17)
AML
nucleocytoplasmic shuffling protein
Favorable prognosis
127
Tennis racket
Langerhans cell Histocytic neoplasm
128
Hand-Schuller-Christian triad
in Langerhans cell neoplasm
Bone Defect
Diabetes Insipidus
Exophthalmos
129
Associated with Rheumatoid and high Ferritin levels
HLH
| Hemophagocytic lymphohistocytosis
130
3 regions of hypervariablility
CDR1,2,3
131
Heavy chain components
D to J to V to C
132
Light chain components
V to J to C
133
Junctional diversity
removal or addition of nucleotides
134
Allelic exclusion
maternal rearranges first
if successful. paternal is not expressed.
Only Maternal OR Paternal expressed
135
positive selection
weak self
136
Neg selection
strong self recognition
137
death via neglect
no self recognition
138
pancytopenia in mature B-cell leukemia
Hairy cell
139
Rheumatoid
Eosinophilic granules
CD 8
T-cell Large granular Lymphocytic leukemia
140
no plasma cells in bone marrow
| 80% upper respiratory
Plasmacytoma
141
Waldenstrom macroglobulinemia
Lymphoblastic lymphoma
Visual impairment
Raynauds
142
peripheral follicles
B-cells
143
Paracortex in medulla
T cells and macrophage
144
High endothelial venules
lymphocyte homing receptors
145
Primary follicle
Naive B cell
146
Secondary B follicle
lighter zone surrounded my dark mantle zone
| B cells become activated
147
tingible body macrophages
in germinal centers
| stars in 'starry sky' of burkitt lymphoma
148
Gout
| Ruddy Face
PV
