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Compounding > Quiz 2 > Flashcards

Quiz 2 Flashcards

1
Q

What are capsules made of?

A

gelatin
sugar
water

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2
Q

What is a good alternative for capsule shell if animal sources cannot be used?

A

HPMC

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3
Q

Advantages of Capsules

A

easy to compound
unit dose
presentation
dosage form

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4
Q

Limitations of capsules

A

can’t have highly soluble drugs
can’t have efflorescent compounds
can’t have deliquescent compounds

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5
Q

Disadvantages of Capsules

A

cannot cut in half
can dry or swell based on humidity
tampering

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6
Q

What humidity should capsules be stored at?

A

30-45%

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7
Q

What is the largest capsule size to swallow?

A

00

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8
Q

What capsule size can be used rectally or vaginally?

A

000

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9
Q

Rule of 7

A

subtract grains of powder weight from 7 to get capsule size

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10
Q

Rule of Sixes

A

0 - 6-7 gr
1 - 5 gr
2 - 4 gr
3 - 3 gr
4 - 2 gr
5 - 1/2-1 gr

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11
Q

Quality Control tests are used for capsules for?

A

content uniformity
weight variation (+/- 10%)

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12
Q

For the punch method, what do you do?

A

Calculate for at least 1 extra capsule
triturate powders to same size and mix by geometric dilution
weigh empty capsule
create a packed block as high as 1/2 - 2/3rds of body
punch capsule
weigh filled capsule
clean and polish

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13
Q

Capsule filling machines are filled by ?

A

volume to the max

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14
Q

Does a capsule filling machine require extra capsule calculations?

A

no

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15
Q

Capsule packing statistics determine?

A

% of capsule volume occupied by each ingredient

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16
Q

How can you find a capsule packing statistic?

A

pack 3 or more size 1 capsules and average the weights

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17
Q

parenteral

A

sterile dosage forms that avoid the GI tract

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18
Q

Intravenous Route

A

admin directly into the vein

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19
Q

Intramuscular Route

A

injected deep into large muscle mass
less than or equal to 2.5 mL
vaccines

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20
Q

Subcutaneous Route

A

injected beneath the surface of the skin
less than or equal to 2 mL

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21
Q

IVP

A

intravenous push

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22
Q

IVPB

A

Intravenous piggy back

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23
Q

SVP

A

small volume parenteral
less than or equal to 100mL

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24
Q

LVP

A

large volume parenteral
greater than 100mL

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25
Q

epidural

A

injected into epidural space
we compound for this

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26
Q

Intra-articular route

A

into a joint
we compound for this

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27
Q

Intrapleural route

A

into the sac surrounding the lungs
we compound for this

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28
Q

Intravitrial route

A

into the eye
503B compounds this a lot

29
Q

Intraosseous

A

directly into the bone marrow

30
Q

needle length

A

0.5-2 in

31
Q

needle gauge

A

diameter of shaft
is inversely related to gauge numeral

32
Q

ideal needle for compounding

A

18 gauge x 1.5in

33
Q

what color is the 18 gauge needle?

A

pink

34
Q

Can you use no core needles in patients?

A

no, compounding only

35
Q

Needle filters are how many microns?

A

5

36
Q

What color are sharps containers?

A

red

37
Q

Why don’t we use our thumb to cap needles?

A

you’ll stick yourself
use the counter

38
Q

Do we use self capping needles in compounding?

A

no, the cap gets in the way

39
Q

syringe sizes (mL)

A

1, 3, 5, 10, 20, 30, 60

40
Q

Best practice syringe selection

A

min 20% volume, max 80% volume
ex. 10 mL syringe can have fluids 2-8 mL

41
Q

What is the syringe selection for chemo?

A

75% max, 25% min
ex. if you have a 10 mL syringe it could hold 2.5-7.5 mL

42
Q

How many access ports do IV admixture bags have?

A

2
additive and administrative

43
Q

IV Admixture bags come with how much overfill?

A

10%

44
Q

What volumes in mL do IV admixture bags come in?

A

50, 100, 250, 500, 1000, or empty

45
Q

Normal Saline contents

A

0.9% NaCl
154 mEq of NaCl/ L
308 mOsmol/ L

46
Q

D5W contents

A

5% dextrose
252 mOsmol/ L

47
Q

Mini-Bag Plus and Advantage bag have a “hat” that can attach to what?

A

a vial

48
Q

Duplex bags have what kind of drug?

A

antibiotic

49
Q

Roller clamp adjusts?

A

speed

50
Q

y-site

A

can attach another IV bag

51
Q

guardrails

A

protect the rate of infusion from going too low or too high

52
Q

aseptic technique

A

procedures done to remove the risk of contaminants in compounding

53
Q

Where should items be placed in relation to air flow in the laminar air flow hood?

A

parallel

54
Q

Ability produce a sterile preparation is directly related to the?

A

cleanliness of the work area
the quality of air in the area
process & preparation quality controls

55
Q

What particle sizes present the greatest risk to health?

A

0.3-0.9 microns

56
Q

What is the USP particle size for regulation?

A

greater than or equal to 0.5 microns

57
Q

Which ISO classes fall under clean room theory?

A

5-8

58
Q

Laminar Airflow Hood

A

where compounding takes place
ISO class 5
planar or in sheets

59
Q

Buffer Area

A

where the laminar airflow hood is located
ISO class 7

60
Q

Ante Area

A

prep area for sterile compounding
ISO class 8

61
Q

Air flows from the buffer area to ?

A

ante area

62
Q

DCA

A

direct compounding area

63
Q

HEPA

A

high efficiency particulate air filter
removes 99.97% of particles greater than 0.3 microns
ISO Class 5
for non Hazardous preparations

64
Q

CleanRoom air

A

class 10,000
ISO class 7
gross filtered air

65
Q

6 Inch Rule

A

Work within 6 inches of the laminar airflow hood

66
Q

Should products be placed next to each other or behind each other to prevent contamination?

A

next to each other

67
Q

The blower should be operated for how many minutes prior to compounding?

A

30 mins

68
Q

What should you clean the airflow hood with?

A

70% isopropyl alcohol

69
Q

Vertical Flow Hood

A

air flow downward and not towards the operator
glove box/isolator

Compounding (6 decks)

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