Quiz 2/Midterm 2 Flashcards
(105 cards)
Neuroimaging techniques
brain imaging techniques used to reveal brain structure and function.
Brain anatomy
Accurate information about the site and extent of a lesion very soon after injury. After stoke you can see the lesion.
Brain function
compare healthy individuals vs. individuals suffering from neurological conditions. Compare healthy people with people with a brain disorder, get them to do the same tasks.
Contrast X-rays
Inject a substance into the brain that is differentially absorbed by x-rays depending on the surrounding tissue (e.g., cerebral angiogram). Use a dye to see a specific region.
Use catheter that inserted into thigh and make way to brain to enhance sight of blood vessels to see blockage.
Computed Tomography (CT)
Multiple x-ray scans are computer-enhanced to form a 3D image of the brain. Different densities of bone and tissue and CSF so your able to localized different pats and you can also spot brain tumors.
Bone, tissue, fluid have different absorbency properties
Magnetic Resonance Imaging
In the presence of an external magnetic (MRI machine) and radio frequency waves, hydrogen protons in the brain generate small, measurable magnetic fields.
Brain is mainly water so full of hydrogen and therefore and admit magnetic field.
When you go in there is a magnetic field applied to head and hydrogen will all spin in same direction. Radio freq pulse will be applied and then the hydrogen will move out of line. The pulse will stop and the continue with just magnetic field spinning. Relaxation time for dif tissues at dif density and this is how we get the image as they’re emitting magnetic field.
Magnetic Resonance Imaging FYI
Safe and painless
Provides far more detail than CT scans
Brain Function
Neural activity leads to oxygen consumption
What carries oxygen throughout your body?
O2 metabolism leads to localized changes in blood flow to a region (e.g., hemodynamic response)
Measured by fMRI & PET
Positron Emission Tomography (PET)
Measures local cerebral blood flow (rCBF)
Radioactive tracer injected into blood stream
Image of the levels of radioactivity
Radioactive tracer tricks brain to thinking it is glucose, it will be sent to more active parts of brain. So, it will build up. More level of activity means more radioactive tracer.
Colors of PET
Red - a lot of radioactive tracers
Orange- less
Yellow-lesser
Blue/purple-none
Localizing activity
fMRI Measures…
Changes in Blood Oxygenation (BOLD signal) neural activity goes up + blood oxygen goes up then, fMRI signal goes up
Visual Word Recognition Task
Words vs Letter strings
Control perceiving and then compare experimental and control group
The Active Brain
Cognitive activity = activity of neurons
Neurons performing similar functions tend to cluster together (functional specialization), for example the neurons that function the visual are clustered in the occipital lobe.
Neural activity generates electrical signals
Measure activity with electrophysiological techniques
Single-cell recording, Electroencephalgram (EEG), Magnetoencephalography (MEG)
Electroencephalogram (EEG)
Electrodes placed on the scalp
Measures summed electrical potentials from millions of neurons
Use gel to help capture the electrode activity at the scalp of the head.
Capturing post-synaptic potentials in EEG study (EPSPs specifically)
Used clinically and in research
Neurological disorders that EEG can help with diagnosis and the impact (eg., Epilepsy)
Event-related brain potentials or Evoked Potentials
ERPs are derived from EEG via signal averaging.
Reflect the brain’s detection and response to an event
Provide a record of cognitive processing as it unfolds in time
Link specific ERPs to a cognitive function via experimental manipulations
If you want to see the electrode activity while people are doing a task you need to repeat the task over and over
Do it 30-50 times and then average over all trials, you cancel all things that are happening internally and externally to get the wave of signal happening during the task.
Hard to assess people with autism, so use ERP
ERP Primer-Semantic Priming Task
Is the target related to the prime? What is the brain wave that can be captured when you have to fully process the meaning of the word?
ERP signal
average of the EGG signal
The BIG WAVE in ERP
The big wave is the processing of the meaning of the presented word
UP?
DOWN?
Up=negative
Down=positive
Naming Convention- N400
N= negative going
400 peaks approx. 400 msec after stimulus onset
*N400-linked to semantic processing
Invasive Physiological Research Methods
Mainly limited to animal research:
-Lesioning
-Electrical stimulation
-Invasive recording methods
Invasive Physiological Research Methods
Mainly limited to animal research:
-Lesioning
-Electrical stimulation
-Invasive recording methods
Stereotaxic Surgery
Used to position experimental devices within the brain
Stereotaxic atlas
provides coordinates for locating structures within the brain