Quiz 2 Practice Questions

Question 1

Immunoglobulin light chain

Answer 1

VJ

Question 2

TCR alpha chain

Answer 2

VJ

Question 3

TCR beta chain

Answer 3

VDJ

Question 4

Immunoglobulin heavy chain

Answer 4

VDJ

Question 5

DCs vs MPs

Answer 5

Sim: phagocytes, leukocytes, tissue residents, degrade pathogens
Diff: DCs transport antigen from epithelia to draining LN to activate naive T cells

Question 6

T cell Ag

Answer 6

8-25 AA peptide

PRIMARY structure recognized as non-self AFTER DEGRADATION

Question 7

CD8+ T cells

Answer 7

activation -> activate B cell

kill infected cells by inducing apoptosis

Question 8

most abundant serum Abs

Answer 8

GAM

IgG, IgA, IgM

Question 9

Abs expressed on naive B cell

Answer 9

DM

IgD or IgM

Question 10

somatic hypermutation

Answer 10

mutational mechanism resulting in production of abs that bind antigen w/higher affinity

Question 11

isotype switching

Answer 11

results in change of constant region of heavy chain of abs, causing change in effector fxn and transport properties of abs

Question 12

Incontrasttoimmunoglobulins,alpha\betaT‐cellreceptorsrecognize epitopespresentonantigens:
A.  carbohydrate 
B.  lipid 
C.  protein 
D.  carbohydrateandlipid 
E.  carbohydrate,lipidandprotein.

Answer 12

PROTEIN

Question 13

WhichofthefollowingcharacteristicsiscommontobothT‐cellreceptorsandimmunoglobulins?
A. SomaticrecombinationofV,DandJsegmentsisresponsibleforthediversityofantigen‐
bindingsites.
B. Somatichypermutationchangestheaffinityofantigen‐bindingsitesandcontributesto
furtherdiversification.
C. Classswitchingenablesachangeineffectorfunction.
D. Theantigenreceptoriscomposedoftwoidenticalheavychainsandtwoidenticallight
chains.
E. Carbohydrate,lipidandproteinantigensarerecognizedandstimulatearesponse.

Answer 13

SOMATIC RECOMBINATION OF VDJ INCREASES FAB DIVERSITY IN TCRS AND BCRS

Question 14

TCR Fab

Answer 14

V alpha + V beta

Most VARIABLE domains on TCR

Question 15

TCRs recognize…

Answer 15

PEPTIDES BOUND TO MHC

Question 16

CD8 T cells combat…

Answer 16

INTRAcellular pathogens

Question 17

CD4 T cells combat…

Answer 17

EXTRAcellular pathogens

Question 18

CD4 Th1 cells activate…

Answer 18

Macrophages

Question 19

CD4 Th2 cells activate and are associated with

Answer 19

B cell activation

HIV infection

Question 20

MHC I peptide-binding groove

Answer 20

Alpha 1 + alpha 2

Question 21

CD4 binds ____ MHC II domain

Answer 21

Beta 2

Question 22

CD8 binds ___ MHC I domain

Answer 22

Alpha 3

Question 23

MHC I peptide processing

Answer 23

proteasome -> TAP 1/2 -> ER -> MHC I -> plasma membrane

Question 24

MHC II peptide processing

Answer 24

endocytosis -> proteases -> remove CLIP from MHC II -> peptide binds MHC II -> plasma membrane

Question 25

Peptide-binding motif

Answer 25

combo of anchor residues in peptide that are capable of binding a particular MHC haplotype

Question 26

MHC restriction

Answer 26

specificity of TCR for particular peptide/MHC complex

Question 27

Balancing selection

Answer 27

maintenance of variety of MHC isoforms in a population

Question 28

Directional selection

Answer 28

replacement of older MHC isoforms with newer variants

Question 29

Interallelic conversion

Answer 29

gene conversion b/w alleles on homologous chromosomes

Question 30

Dendrites

Answer 30

Highly elaborated finger-like processes on activated DCs upon arriving at LNs

Question 31

Immunological synapse

Answer 31

area of contact between membranes of a T cell and an antigen‐presenting cell where a  clustering of protein–protein interactions occur

Question 32

Th2 cytokines differentiate...

Answer 32

B cells

Question 33

T cell prolif induced by...

Answer 33

IL-2 binding of HIGH affinity receptor -> T cell prolif of activated T cells

Question 34

IFNg transcr factor for which cell

Answer 34

T-bet CD4 Th1 cell FOR MY MEMORY: I F'n betcha won!

Question 35

IL-4 transcr factor for which cell

Answer 35

GATA-3 CD4 Th2 cell FOR MY MEMORY: 2345, 13

Question 36

Cytokine receptors associated w/...

Answer 36

JAK=cytoplasmic protein kinase | STAT=transcription factor

Question 37

CD8 T cells make...

Answer 37

IFNg, TNFa, lymphotoxin, Fas ligand

Question 38

CD4 Th2 cells make...

Answer 38

IL-4, CD40L, TGF-b, IL-10

Question 39

Signal transducers and activators of transcription (STATs) are

Answer 39

Transcr factors (JAKs)