Quiz 3 Flashcards

(97 cards)

1
Q

macrolides

A

antimycobacterial 2nd line

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2
Q

terbinafine

A

other antifungals

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3
Q

anidulafungin

A

Echinocardins

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4
Q

ethionamide

A

antimycobacterial 2nd line

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5
Q

erythromycin

A

macrolides/ketolides

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6
Q

posaconazole

A

azole

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7
Q

voriconazole

A

azole

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8
Q

methenamine

A

urinary tract antiseptics

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9
Q

interferon

A

antiviral ( hepatitis)

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10
Q

acydovir

A

antiviral herpes

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11
Q

ofloxacin

A

flouroquinolone

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12
Q

rifampin

A

antimycobacterial 1st line

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13
Q

flucytosine

A

Other Antifungals

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14
Q

tigecycline

A

tetracyclines

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15
Q

clarithromycin

A

macrolides/ketolides

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16
Q

Amphotericin B

A

polyene Ab

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17
Q

isoniazid

A

antimycobacterial 1st line

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18
Q

trifluridine

A

antiviral herpes

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19
Q

demeclocycline

A

tetracyclines

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20
Q

micafungin

A

Echinocardins

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21
Q

oseltamivir

A

antiviral ( Influenza)

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22
Q

cotrimoxazole

A

antifolate drugs “sulfas”

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23
Q

sulfamethoxazole

A

antifolate drugs “sulfas”

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24
Q

azithromycin

A

macrolides/ketolides

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25
ethambutol
antimycobacterial 1st line
26
valacyclovir
antiviral herpes
27
caspafungin
Echinocardins
28
capreomycin
antimycobacterial 2nd line
29
gemfloxacin
flouroquinolone
30
gentamicin
aminoglycosides
31
nitrofurantoin
urinary tract antiseptics
32
rifabutin
antimycobacterial 1st line
33
telithromycin
macrolides/ketolides
34
ribavirin
antiviral ( hepatitis)
35
boceprevir
antiviral ( hepatitis)
36
rifapentin
antimycobacterial 1st line
37
moxifloxacin
flouroquinolone
38
chloramphenicol
" Others" protein synthesis Ab
39
famciclovir
antiviral herpes
40
telaprivir
antiviral ( hepatitis)
41
tobramycin
aminoglycosides
42
sulfectamide
antifolate drugs "sulfas"
43
linezolid
Others" protein synthesis Ab
44
cidofovir
antiviral ( cytomegalovirus infections)
45
nystatin
polyene Ab
46
ketoconazole
azole
47
ciprofloxacin
flouroquinolone
48
tenofivir
antiviral ( hepatitis)
49
fidaxomicin
macrolides/ketolides
50
ganciclovir
antiviral ( cytomegalovirus infections)
51
doxycycline
tetracyclines
52
zanamivir
antiviral ( Influenza)
53
trimethropim
antifolate drugs "sulfas"
54
sulfadiazine
antifolate drugs "sulfas"
55
clindamycin
Others" protein synthesis Ab
56
minocycline
tetracyclines
57
flouroquinolones
antimycobacterial 2nd line
58
itraconazole
azole
59
amikacin
aminoglycosides
60
streptomycin
aminoglycosides
61
norfloxacin
flouroquinolone
62
griseofulvin
other antifungals
63
cycloserine
antimycobacterial 2nd line
64
pyrazinamide
antimycobacterial 1st line
65
fluconazole
azole
66
levofloxacin
flouroquinolone
67
rimantadine
antiviral ( Influenza)
68
Amantadine
antiviral ( Influenza)
69
neomycin
aminoglycosides
70
lamivudine
antiviral ( hepatitis)
71
- block viral membrane matrix protein M2 - functions as a channel for hydrogen ions -
Antiviral MoA ( respiratory)
72
- Enter Bacteria by passive diffusion - inhibit replication of DNA by interfering with DNA gyrase and topoisomerase IV
Flouroquinolones MoA
73
- active molecule targets enzymes responsible for synthesis of mycolic acid and blocks its production - interacts with bacterial RNA polymerase - decreases ic pH and inhibits growth
Antimicrobial Drugs 1st Line MoA
74
- interfere with the synthesis of beta glucan - disrupts cell wall - causes lysis and cell death
Echinocardins MoA
75
- inhibits P450 enzyme responsible for converting lanosterol to ergosterol - inhibits human gonadal and adrenal steroid synthesis
Azoles MoA
76
- reversibly bind to the 30s ribosomal subunit and prevent the binding of tRNA - prevents the addition of new amino acids to the growing peptide chain - inhibits protein synthesis
Tetracyclines MoA
77
- binds to 30s ribosomal subunit and interfers with initiation of protein synthesis - interferes with initiation complex of peptide formation
aminoglycosides MoA
78
Binds to 50s subunit blocks peptidyltransferase center
macrolides MoA
79
decomposes at 5.5 or less produces formaldehyde toxic to bacteria
urinary tract antiseptics MoA
80
-structural analogues of PABA compete with dihydropterase synthetase inhibit folate production
sulfanomides MoA
81
- not completely understood thought to induce host cell enzymes to inhibit viral RNA translation
anitiviral MoA ( hepatic)
82
- converted to active form by viral enzyme ( thymine kinase) - competes as a substrate for viral DNA polymerase ans is incorp into the viral DNA
antiviral MoA ( herpes )
83
inhibitis dihydrofolate reductase higher affinity for bacterial enzyme than mammalian
Trimethoprim MoA
84
- decomposes at pH of 5.5 or less - produces formaldehyde which is toxic to bacteria
Methenamine MoA
85
Damages bacterial DNA
Nitrofurantoin MoA
86
bind to ergosterol in the plasma membrane and form a pore this allows small molecules to escape -\> cell death
Amphotericin B
87
enters fungal cell and disrupts DNA/protein synthesis
Flucysotine MoA
88
- inhibits squalene epoxidase - blocks synthesis of ergosterol , squalene buillds up and becomes toxic
Terbinafine MoA
89
- inhibits fungal mitosis - deposited in newly forming skin protecting it from new infection - induces hepatic P450 activity
Griseofulvine MoA
90
- prodrug; activated by mycobacterial enzyme - active molecule targets enzymes responsible for synthesis of mycolic acid and blocks its production
Isoniazid MoA
91
lowers ic pH and inhibits growth
Pyrazinimide MoA
92
interferes with cell wall synthesis
ethambutol MoA
93
- block viral membrane protein M2 inhibits viral encoding
Amantadine and Rimantadine MoA
94
induce host cell enzymes to inhibit viral RNA translation
Interferon MoA
95
inhibits Hepatitis B DNA polymerase and HIV reverse transcriptase
Lamivudine MoA
96
blocks synthesis of viral DNA and RNA
Ribavirin MoA
97
binds to active site of Hep C Virus protease
Boceprevir and Telaprevir MoA