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Flashcards in Quiz 4 Deck (34):
1

Aminoglycosides act on DNA synthesis.

FALSE

2

All bacteria have lipopolysacharide (endotoxin) in their cell walls.

FALSE
-Only gram negative organisms have endotoxin in their cell wall.

3

Light microscopy can be used in the routine laboratory to examine unstained specimens of urine and cerebrospinal fluid (CSF) for the presence of pus cells (white blood cells).

TRUE

4

An organism which is sensitive to an antibiotic will always be killed by it.

FALSE

5

Penicillin allergic patients may also be allergic to cephalosporins.

TRUE

6

Light microscopy can be used in the routine laboratory to screen faeces for the presence of vires.

FALSE
-Viruses can only be seen by electron microscopy.

7

Third generation cephalosporins (eg, ceftazidime) have better anti-staphylococcal activity than the earlier cephalosporins

FALSE

8

Concerning diagnostic methods: direct immunofluorescence can be used to identify specific organisms in clinical material.

TRUE

9

Pasteurisation results in sterilisation of milk.

FALSE
-Pasteurization can be used on many other liquids (eg plasma) but it will only reduce the bacterial load, not sterilize the liquid.

10

All bacteria have lipopolysaccharide (endotoxin) in their cell walls.

FALSE
-Only Gram negative organisms have endotoxin in their cell wall.

11

Malaria is never passed from human to human.

FALSE
-Malaria can be transferred via blood transfusion.

12

Amphotericin B treatment should not be started until laboratory sensitivity results are available.

FALSE

13

Concerning diagnostic methods: A single elevated IgM titre is generally acceptable as serological proof of infection.

TRUE
-IgM represents the acute response and therefore suggests current infection.

14

Prophylaxis should be given before every operation.

FALSE

15

The complement fixation test detects killed virus in the patients blood.

FALSE

16

Gentamicin is associated with ototoxicity, and all aminoglycosides are ototoxic.

TRUE

17

Trimethoprim interferes with protein synthesis at the ribosomal level.

FALSE

18

Concerning diagnostic methods: a single elevated IgG titre is generally acceptable as serological proof of infection.

FALSE
-A rising litre would be required.

19

An infection should be treated with an antibiotic with high MIC for the causative organism.

FALSE

20

Neisseria gonorrhoea is an example of a Gram-negative bacillus.

FALSE
-It is a gram negative cocci.

21

Escherichia coli is an example of Gram-negative bacillus.

TRUE

22

Metronidazole is widely used to treat anaerobic infection.

TRUE

23

Amphotericin acts against a wide range of bacteria.

FALSE

24

Blood and Cerebrospinal (CSF) have their own normal bacterial flora.

FALSE
-These are sterile sites.

25

Concerning diagnostic methods: ELISA (also called EIA) tests can be designed to measure antigen or antibody in serum.

TRUE

26

A four fold rise in antigen is required to make a serological diagnosis.

FALSE
-Antigen is either present or absent. A four fold rise in antibody titre is usually required for a serological diagnosis the difference between antigen and antibody is basic and important.

27

Diagnosis of malaria is made by visualisation of parasites in a peripheral blood film.

TRUE

28

Bacterial exotoxins are released on cell death.

FALSE
Exotoxins are usually released by the live organism. Endotoxin is released on cell death.

29

Concerning diagnostic methods: a single elevated IgG titre is generally acceptable as serological proof of infection.

FALSE
-A rising litre would be required.

30

Concerning bacterial culture: all clinically important bacteria grow within 48 hours.

FALSE
- There are many slow growing organisms (eg, Mycobacterium tuberculosis can take 4 - 6 weeks to grow).

31

Fluconazole is active against yeasts but not against filamentous fungi such as Aspergillus.

TRUE

32

The complement fixation test measures only IgG antibody in the patients serum.

FALSE
-The complement fixation test measures antibody in the patients serum by virtue of its ability to fix complement. Thus it detects a mixture of IgG and IgM and does not distinguish between them.

33

Clostridium tetani is an example of a Gram-positive coccus.

FALSE

34

Concerning diagnostic methods: A single elevated IgM titre is generally acceptable as serological proof of infection.

TRUE
-IgM represents the acute response and therefore suggests current infection.