Flashcards in Quiz 5 Deck (26)
Are 1° or 2° (metastatic) tumors of the liver more common?
2° - metastasis from other tissues
frequently GI - colon cancer
MC 1° liver tumor:
hepatic hemangioma (benign)
MC 1° liver cancer:
hepatocellular carcinoma (hepatoma)
2nd MC - cholangiocarcinoma (<10%)
Vascular tumor of the liver characterized by dilated vascular spaces filled with blood:
Hepatic adenoma risk is increased in young women who use:
resolves upon discontinuation of the pill
Hepatic adenomas are (benign/malignant) and have potential to (metastasize/rupture).
Hepatic adenoma appearance - gross:
cells resemble normal hepatocytes
loss of lobar architecture
Cancer coming from cells that line the bile ducts & create sinus passages for bile flow:
Rare 1° forms of liver cancer:
sarcoma of the liver
In countries such as China, where it is endemic, _______ is the MC cause of hepatocellular carcinoma.
HBV (viral hepatitis)
MC cause in US: cirrhosis (2° to alcohol or HCV)
Histology of HCC:
loss of normal architecture
Infants who contract HBV at birth have a _____x increased risk of developing HCC.
A clue to the presence of a HCC neoplasm is an elevated:
may also obstruct biliary tract & lead to elev serum alk phos
Is HCC MC in men or women?
Risk factors for development of cholangiocarcinoma:
chronic injury of the biliary epithelium
classified as: intra- or extra-hepatic
intra- further classified: hilar or peripheral (MC)
Tumor markers you might use to differentiate cholangiocarcinoma from HCC:
Type of endothelial tumor that may occur in the skin & soft tissue organs, such as breast, heart:
hepatic angiosarcomas are rare
What exposure is of notable interest d/t association with hepatic angiosarcoma?
such as pesticides, polyvinyl chloride in plastics
Biliary atresia occurs as a (congenital/acquired) dz?
congenital - common bile duct blocked/absent
acquired - MC in autoimmune dz, common form of chronic rejection of a transplanted liver allograft.
Features of biliary atresia in infants:
fat-soluble vit deficiencies
eventual cirrhosis w/portal HTN
=> liver failure
Congenital cystic dilatations of the bile ducts:
MC - Type I (80-90%)
most dx'd during infancy/childhood, mb found at any age
Most feared complication of choledochal cysts:
cholangiocarcinoma (9-28% incidence)
Choledochal cyst presentation - infants:
Infants - jaundice, clay-colored stool, palpable mass in RUQ, hepatomegaly
Children - palpable mass in RUQ, jaundice, OR intermittent colicky abd pain (ssx like pancreatitis)
Adults - MC abd pain (vague epigastric/RUQ pain),
jaundice, cholangitis, mb palpable RUQ abd mass
Crystalline mass formed in GB by accretion of bile components:
Risk factors for cholelithiasis:
fat, female, 40
N/S American Indian
prolonged PPI use
lack of melatonin
low fiber/high cholesterol diet
high starch diet
rapid wt loss
low intake of: folate, mg, ca, vit C