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Zak, MSK 2 > RA Pharmacology > Flashcards

RA Pharmacology Flashcards

1
Q

MOA: Prednisone

A

Acts on NF-kß and AP-1 to cause immunosuppression Activates Lipocortin which inhibits PLA2

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2
Q

MOA: Methotrexate

A

Blocks Thymidylate Synthase –> accumulation of AICAR –> adenosine efflux –> adenosine activating GPCR –> anti-inflammatory effects

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3
Q

MOA: Hydroxychloroquine

A

Weak base that increases pH in lysosomes preventing peptide loading onto MHC2

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4
Q

MOA: Leflunomide

A

Blocks synthesis of ribonucleotides inhibiting T cell proliferation

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5
Q

MOA: Etanercept

A

TNF inhibitor

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6
Q

MOA: Infliximab

A

TNF inhibitor

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7
Q

MOA: Adalimumab

A

TNF inhibitor

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8
Q

MOA: Rituximab

A

Binds CD20 on B cells acting as opsonizing agent –> depletion of immature B cells –> decreased production of autoAb

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9
Q

MOA: Abatacept

A

Prevents CD28 binding w/ CD80/86 preventing activation of T cells by APCs

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10
Q

MOA: Tocilizumab

A

Anti-IL-6R IgG Ab limiting hepatic acute phase response

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11
Q

MOA: Tofacitinib

A

JAK3 enzyme inhibitor

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12
Q

MOA: Anakinra

A

Blocks pro-inflammatory activity of IL-1

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13
Q

Clinical application: Prednisone

A

Relieve pain/inflammation until DMARD kicks in Tx for flare ups

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14
Q

Clinical application: Methotrexate

A

1st choice for RA

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15
Q

Clinical application: Hydroxychloroquine

A

Combined w/ MTX (safe in pregnancy)

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16
Q

Clinical application: Sulfasalazine

A

Alone or combo (safe in pregnancy)

17
Q

Clinical application: Leflunomide

A

Last choice for RA

18
Q

Clinical application: Rituximab

A

Combo w/ MTX in pts w/ RA not responding to TNFi’s

19
Q

Clinical application: Abatacept

A

Moderate/Severe RA when TNFi’s fail

20
Q

Clinical application: Tocilizumab

A

Moderate/Severe RA when DMARDs and TNFi’s fail

21
Q

Clinical application: Tofacitinib

A

Moderate/Severe active RA

22
Q

Clinical application: Anakinra

A

Moderate/Severe RA

23
Q

Major SE’s: Hydroxychloroquine

A

Retinal damage

24
Q

Major SE’s: Leflunomide

A

Respiratory infection Reversible alopecia

25
Q

Major SE’s: Abatacept

A

Serious infection

26
Q

Major SE’s: Tocilizumab

A

URI

27
Q

Major SE’s: Tofacitinib

A

Fatal/opportunistic infections Malignancy

28
Q

What drugs are in the Non-biologic DMARD category

A

MTX Hydroxychloroquine Sulfasalazine Leflunomide

29
Q

What drugs are in the Biologic DMARD category

A

Etanercept, Infliximab, Adalimumab Rituximab Abatacept Tocilizumab Tofacitinib Anakinra

Zak, MSK 2 (17 decks)

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