Radiochemistry/Pharmacy Flashcards
(68 cards)
A chemical substance that contains radioactive atoms within its structure and is suitable for administration to humans for diagnosis or treatment of disease is known as a (an):
Radiopharmaceutical
Allergic reactions to radiopharmaceuticals are very common due to the large amount of active ingredients found in their formulations: (T/F)
False
Which of the agency is responsible for regulating and monitoring the manufacture, distribution, safety, and effectiveness of all drugs and medications, including radiopharmaceuticals, in the United States?
Food & Drug Administration (FDA)
The atomic mass of an element represents __________.
The number of protons and neutrons in one atom of an element. (Electrons are also included but the majority of the time, are excluded from calculations)
Based on manufacturer recommendations, Tc99m elution expires at:
12 Hours
A unique characteristic of a pharmaceutical includes __________, whereas a unique characteristic of an isotope includes ______________.
Biodistribution, half-life
The half-life of a radionuclide is ____________.
The time for any quantity of radionuclide to decrease to half its original value.
A radiopharmaceutical decaying as a (Beta -) emitter would most likely be useful in which of the following applications?
Therapy
The amount of radioactivity administered to a patient (dosage) is expressed in:
Curies (Ci)
The mechanism of decay for nuclides that have too many protons relative to the numer of neutrons is:
(Beta +)
When one of the species in a coordination compound is a metal ion, the resulting entity is known as a metal complex. Electron donor atoms that bond with the metal ion are donated by a species known as a(an) ___________.
Ligand
Radiopharmaceutical kits reconstitued with Tc99m Pertechnetate are prepared in nitrogen- or argon- purged vials to prevent:
Oxidation
Which of the following is not part of a commercially produced Tc99m radiopharmaceutical reagent vial?
a) Stannous Ion
b) Reducing Agent
c) Lyphilized Compound
d) Preservative-free Saline
d) Preservative-free Saline
What effect does hydrolysis have on the desired radiopharmaceutical product?
Produces Tc99mO2 complexed with other ingredients.
When labeling Tc99m (VII), in what state is the Tc99m changed to make it more reactive?
(IV) (4)
What is the purpose of ITLC (Instant Thin Layer Chromatography)?
Separate substances into their components.
A Tc-99m MDP dose is 20 mCi calibrated at 11:00. The patient shows up 3 hours late for their study. How much activity remains in the dose?
14.1 mCi
25 mCi is equivalent to how many MBq?
925 MBq
Which of the following components in a Tc99m labeled radiopharmaceutical preparation is a radiochemical impurity?
a) Aluminum
b) Mo99
c) 0.9% NaCl
d) Tc99m04-
d) Tc99m04-
The test kit used to measure aluminum ion concentration in Tc99m elute contains specially treated indicator paper and an aluminum solution with concentration of approximately:
10 ug/mL
On the basis of USP criteria, MAA particle size should be no larger than __________ in size?
150 um
What is the purpose of heating some kits during preparation?
Supply energy to complete the chemical reaction
Which species is not part of a Tc99m radiopharmaceutical preparation?
a) Tc99m04-
b) Hydrolyzed-Reduced Tc99m
c) Tc99m - Chelate
d) Tc99m - Buffer
d) Tc99m - Buffer
Microembolization of particles describes which method of localization?
Capillary Blockade
