Random Flashcards
(52 cards)
What polypeptide chains does hemoglobin f have?
2 alpha
2 gamma
What is the amino acid substitution that causes sickle cell anemia?
Valine is substituted for glutamic acid at sixth position on beta chain
What is the function of a plasma cell?
Activated b-lymph that is actively synthesizing antibody
How might lymphoma cells be recognized on Wright Stain peripheral smears?
A cleft in the nucleus in the lymphocytes.
What is the difference between a lymphoma and leukemia?
Lymphoma occur in the lymph nodes and leukemias occur in the bone marrow
What is a hemoglobinopathy?
Disease of abnormal hemoglobin
What is the main site of hematopoiesis?
Flat bones
The majority of rbcs are removed from the body by what type of catabolism?
Extra vascular
The packed cell volume is also known as?
Hematocrit
EDTA, heparin, and sodium citrate are all examples of…
Anticoagulants
What statistical term reflects the best general index of precision?
Coefficient of variation (CV)
What is considered normal?
+ or - 2 standard deviations from the mean
What are Howell-Jolly bodies made of?
DNA fragments of the nucleus
What are Pappenheimer bodies made of?
Iron aggregates
What are Heninz bodies made from?
Precipitated, denatured hemoglobin
What is the basophilic stippling in a RBC?
RNA and ribosomes
The MCHC reflects the…
Concentration of hemoglobin in RBCs
What are platelets made from?
Fragments of the megakaryocyte cytoplasm
Is the Wright stain used to detect Heinz bodies?
No
Why does a person with sickle cell trait have an advantage against a person without or with sickle cell disease?
The parasite burrows in the rbcs taking up the oxygen
What chains are in hemoglobin Bart’s?
4 gamma chains
What are knuckle cells associated with?
Hemoglobin SC
The cause of most aplastic anemias?
Unknown or uncertain
What is the migration pattern for electrophoresis using cellulose acetate?
A
F
S
C