Random Flashcards

(52 cards)

0
Q

What polypeptide chains does hemoglobin f have?

A

2 alpha

2 gamma

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1
Q

What is the amino acid substitution that causes sickle cell anemia?

A

Valine is substituted for glutamic acid at sixth position on beta chain

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2
Q

What is the function of a plasma cell?

A

Activated b-lymph that is actively synthesizing antibody

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3
Q

How might lymphoma cells be recognized on Wright Stain peripheral smears?

A

A cleft in the nucleus in the lymphocytes.

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4
Q

What is the difference between a lymphoma and leukemia?

A

Lymphoma occur in the lymph nodes and leukemias occur in the bone marrow

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5
Q

What is a hemoglobinopathy?

A

Disease of abnormal hemoglobin

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6
Q

What is the main site of hematopoiesis?

A

Flat bones

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7
Q

The majority of rbcs are removed from the body by what type of catabolism?

A

Extra vascular

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8
Q

The packed cell volume is also known as?

A

Hematocrit

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9
Q

EDTA, heparin, and sodium citrate are all examples of…

A

Anticoagulants

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10
Q

What statistical term reflects the best general index of precision?

A

Coefficient of variation (CV)

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11
Q

What is considered normal?

A

+ or - 2 standard deviations from the mean

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12
Q

What are Howell-Jolly bodies made of?

A

DNA fragments of the nucleus

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13
Q

What are Pappenheimer bodies made of?

A

Iron aggregates

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14
Q

What are Heninz bodies made from?

A

Precipitated, denatured hemoglobin

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15
Q

What is the basophilic stippling in a RBC?

A

RNA and ribosomes

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16
Q

The MCHC reflects the…

A

Concentration of hemoglobin in RBCs

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17
Q

What are platelets made from?

A

Fragments of the megakaryocyte cytoplasm

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18
Q

Is the Wright stain used to detect Heinz bodies?

A

No

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19
Q

Why does a person with sickle cell trait have an advantage against a person without or with sickle cell disease?

A

The parasite burrows in the rbcs taking up the oxygen

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21
Q

What chains are in hemoglobin Bart’s?

A

4 gamma chains

22
Q

What are knuckle cells associated with?

A

Hemoglobin SC

23
Q

The cause of most aplastic anemias?

A

Unknown or uncertain

24
Q

What is the migration pattern for electrophoresis using cellulose acetate?

25
The symptoms of Beta Thalassemia | would be detected?
A few months after birth
26
The primary cause of vitamin b12 deficiency is?
Malabsorption
27
Hemoglobinemia, hemoglobinuria, and hemosiderinuria are indicators of?
Intravascular hemolysis
28
Intrinsic factor is synthesized by the?
Stomach
29
Hyper segmented neutrophils are associated with what RBC anemia?
Vitamin B12 deficiency
30
Where is most of the body's iron?
Circulating RBCs
31
Transferrin is what?
Iron transport protein
32
How many genes are required for normal hemoglobin beta chain synthesis?
Two
33
A common feature of Sideroblastic anemias is?
Marrow NRBCs with excess cytoplasmic iron
34
Hemoglobin C is most common in?
African Americans
35
Aplastic anemias commonly demonstrate a decreased production of?
All hematopoietic precursors
36
What race is hereditary hemochromatosis common in!
Northern Europeans
37
What is a control specimen?
A blood like specimen with a known range
38
What is the most practical test to diagnose infectious mononucleosis?
Serological test for heterophile antibodies
39
A ground glass cytoplasm is associated with?
Monocytes
40
When trying to identify a cell as mature or immature, what should be the single most important characteristic to evaluate?
Nuclear chromatin
41
The earliest granulocyte in which secondary or specific granules appear in is the?
Myelocyte
42
What is diapedesis?
Cells moving from the marginal pool to the circulating blood
43
What are retics?
Anuclear RBC with cytoplasmic RNA
44
The byproduct of heme catabolism that is toxic and must be excreted is?
Bilirubin
45
The progression of erythropoiesis from prenatal life to adulthood is?
Yolk sac ➡️ lived and spleen ➡️ bone marrow
46
What is the most common acute leukemia in children 2-10 years old?
ALL
47
What condition do you see Auer rods?
AML
48
The most common chronic leukemia is?
CLL
49
CLL is usually a _________ disorder.
B-cell
50
Pro lymphocytic leukemias are characterized by?
Immature looking lymphocytes with nucleoli and large numbers of lymphs with scanty cytoplasm
51
Rouleaux formation may be useful to identify what diseases?
Multiple myeloma and Waldenstroms macroglobulinemia
71
What CBC results are affected by lipemia?
Hemoglobin