Random

Question 1

Drugs used for parkinsons

Answer 1

Carbidopa/levodopa
Dopamine agonists: ropinerole, pramipexole
COMT inhibtors: entacapone
Rescue: amorphine
Anticholinergics: benztropine (for tremors)
MAOBs: selegaline (for tremors)
Amantadine (for dyskinesia)

Question 3

Drugd used for Alzheimer’s

Answer 3

Donepazil, rivastigmine, galantamine (acetylcholinesterase inhibitors), memantine

Question 4

Epilepsy terminology

Answer 4

Tonic: rigid or tense (stiff) muscles
Clonic: jerking movements
Myoclonus: muscle twitching
Atonic: limp or weak muscles

Question 5

Acute seizure treatment

Answer 5

Stabilize (0-5 min)
IV lorazepam or IM midazolam (5-20 min)
IV fosphenytoin, valproic acid, levitiracetam (20-40 min)

Question 6

Braod antiepileptics

Answer 6

Lamotrigine
Levitiracetam
Valproic acid
Topiramate

Question 7

What to supplement with AEDs

Answer 7

Vitamin D + calcium

Question 8

What AEDs not to use in pregnancy

Answer 8

Valproic acid and carbamazepine

Question 9

Which AEDs increase GABA

Answer 9

Phenobarb, levitiracitam, valproic acid, benzos

Question 10

AED MOA besides GABA

Answer 10

Na and Ca channel blockers

Question 10

Which AEDs are enzyme inducers

Answer 10

Carbamazepine, oxcarbazepine, phenytoin, phenobarb, primidone

Question 10

Specific AED drug interaction

Answer 10

Valproic acid increases lamotrigine levels (use lower dose of lamotragine)

Question 11

Which AEDs cause hyponatremia

Answer 11

Carbamzepine, oxcarbazepine

Question 12

Which AED causes myelosuppression

Answer 12

Carbamazepine

Question 13

Max doses of AEDs

Answer 13

Levitiracetam: 3000 mg
Carbamazepine: 1600 mg
Oxarbazepine: 2400 mg
Phenytoin: 50 mg/minute
Topiramate: 400 mg
Lacosamide: 400 mg
Valproic acid: 60 mg/kg

Question 14

AED therapeutic ranges

Answer 14

Phenytoin: 1-2.5 (free) 10-20 (total)

Question 15

SSRI Max doses

Answer 15

Citalopram: 40 mg (20 mg in elderly)
Escitalopram: 20 mg (10 mg in elderly)
Fluoxetine: 80 mg

Question 16

Preferred SSRI in cardiac risk

Answer 16

Sertraline

Question 17

Preferred SSRI with tamoxifen

Answer 17

Venlafaxine

Question 18

Major issues with tricyclics

Answer 18

QT prolongation and anticholinergic

Question 19

Lithium

Answer 19

Na levels inversely affect lithium levels
Toxicity includes ataxia, tremor, arrhythmias, coma, vomiting, CNS depression
Take with food
Therapeutic range: 0.6-1.2
5 mg syrup = 8 mEq lithium ion = 300 mg tabs

Question 20

HCV Treatment

Answer 20

Mavyret or Epclusa

Question 21

Epclusa drug interaction

Answer 21

contains sofosbuvir — interacts with amiodarone
contains velpastavir — interacts with H2RAs and PPIs

Question 22

HBV Treatment

Answer 22

Tenofovir, entecavir or interferon alfa (lamivudine is alternative)

Question 23

PH Treatment

Answer 23

Oral CCB Epoprostenol, selexipag, ambresentan, sildenafil, riociguat

Question 24

Smoking drug interaction

Answer 24

induces CYP enzymes

Question 25

ICR and Correction factor calculations

Answer 25

ICR: 450 (regular) or 500 (rapid) Correction factor: 1500 (regular) or 1800 (rapid)

Question 26

Starting insulin dose T1DM and T2DM

Answer 26

0.5 units/kg/day 0.1-0.2 units/kg/day

Question 27

Levothyroxine IV:PO

Answer 27

0.75:1

Question 28

A1c = BG

Answer 28

6% = 126, each 1% increase is 28