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1
Q

Most common inherited hypercoagulability

A

Factor V Leiden

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2
Q

Most common inherited bleeding disorder

A

von Willebrand Dz

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3
Q

Most common inherited hymolytic anemia

A

HS, test is osmotic fragility

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4
Q

Anemia with absent radii and tumbs, diffuse hyperpigmentation, cafe au lait spots, microcephaly, pancytopenia

A

Fancony anemia

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5
Q

meds that cause aplastic anemia

A

Chloramphenicol, sulfonamides

chemotherapy and radiation

HIV, hepatitis, parvo B19, EBV

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6
Q

TTP pentad?

A

FAT RN
Fever, anemia, thrombocytopenia, Renal dys, neuro abn

Rx: plasmapheresis, roids
plt txfusion contraindictated!

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7
Q

HUS triad?

A

Anemia, thrombocytopenia, AKI

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8
Q

14 yo girl, prolonged bleeding after dental surgery and menses, normal PT, normal or high PTT

A

vWillebrand Dz
Rx: desmopressin, FFP, cryo-ppt

high PTT because vWF stabilizes factor VIII

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9
Q

10 yo boy, fever, weight loss, night sweats, antierior mediastinal mass

A

Suspect Non-Hodgkin Lymphoma

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10
Q

Reed-Sternberg cells

A

Hodgkin lymphoma

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11
Q

80 yo with fatigue, lymphadenopathy, splenomegaly, lymphocytosis (isolated)

A

CLL

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12
Q

Fever, bone pain, splenomegaly, pancytopenia in CML pt

A

Blast crisis, life threatening

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13
Q

Auer Rods

A

AML

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14
Q

AML subtype associated with DIC?

A

M3, Rx with Retinoic Acid

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15
Q

50 yo with early satiety, splenomegaly, bleeding. t(9,22).

A

CML

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16
Q

boy with chronic sinopulmonary infections and negative nitroblue tetrazolium test

A

Chronic granulomatous disease

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17
Q

Child with eczema, thrombocytopenia, high IgA

A

Wiskott-Aldrich syndrome

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18
Q

4 month old boy with life-threatening pseudomonas infection

A

Bruton’s X linked agammaglobluinemia (no b cells)

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19
Q

Vaccinations at 6 mo well child

A

HBV, DTaP, Hib, IPV, PCV, rota

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20
Q

Lung cancer associated with hypercalcemia

A

Squamous cell carcinoma (NSCLC)

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21
Q

lung cancer associated with SIADH

A

Small Cell Lung Cancer (SCLC)

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22
Q

Lung cancer associatd with Lambert Eaton

A

SCLC

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23
Q

RTA associated with abn H+ secretion and nephrolitiasis

A

Type I distal

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24
Q

RTA with abn HCO3- reabsorption and rickets

A

Type II proximal

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25
RTA associated with low aldosterone (low Na, High K)
Type IV distal
26
Most common type of nephrolith
calcium oxalate
27
Test of choice for nephrolith
NONCON ct scan | US next best?
28
Hematuria, HTN, oliguria
Nephritic Syndrome
29
Proteinuria, hypoalbuminemia, hyperlipidemia, edema
nephrotic syndrome
30
Most common nephrotic syndrome in adults
Focal segmental glomerulosclerosis
31
Nephritic syndrome 3 days after URI, normal C3
IgA nephropathy (Berger), immune complex roids for some, ACEI if proteinuria
32
Glomerulonephritis with deafness
Alport Syndrome
33
Glomerulonephritis with hemoptysis
Goodpastures or granulomatosis with polyangitis
34
Red cell casts
glomerulonephritis/nephritic syndrome
35
Eosinophils in urine
allergic interstitial nephritis
36
Waxy casts and maltese crosses
nephrotic syndome
37
muddy brown casts
acute tubular necrosis
38
drowsiness, asterixis, nausea, pericardial friction rub
Uremic syndrome in renal failure
39
hematuria in 50 yo smoker
bladder cancer
40
hematuria, flank pain, palpable flank mass
Renal Cell Carcinoma
41
Testicular cancer with high beta-HCG
choriocarcinoma
42
most common testicular tumor
seminoma, a germ cell tumor
43
most common bladder cancer histology
transitional cell carcinoma
44
Hematuria, oliguria, 2-6 weeks after infection, low C3
Postinfectious glomerulonephritis
45
granulomatosis with polyangiitis systems?
kidney + lung + sinus
46
Microscopic polyangiitis systems?
kidney + lung
47
Churg-strauss systems?
kidney + asthma
48
DDx for low C3 nephritic/nephrotics?
post-infectious GN membranoproliferative GN mixed cryoglobulinemia SLE
49
palpable purpura, arthralgias, nephritic/nephrotic, low C3, positive HCV
mixed cryoglobulinemia (a type of MPGN?)
50
Strep infection 2-6 weeks ago, oliguria, tea or cola colured urine, Low C3, increased anti-DNase titiers, lumpy-bumpy
Postinfectious GN Supportive care with diuretics for fluid overload immune complex
51
palpable purpura, arthralgias, abd pain, normal C3 also Rx?
Henoch-Schonlein purpura, small vessel vasculitis supportive +/- roids
52
Respiratory and sinus symptoms, granulomas, cavitary pulmonary lesions causing hemoptysis, renal involvement, positive cANCA also Rx?
Wegeners (gran with polyang) high-dose roids, cytotoxics, rituximab
53
respiratory symptoms, hemoptysis, renal involvement, pANCA positive, no granulomas also Rx?
Microscopic polyangiitis roids, cyclophosphamide, ritux
54
Asthma, sinusitis, skin nodules/purpura, peripheral neuropathy, pANCA positive, elevated IgE also Rx?
Eosinophilic gran with polyang (churg-strauss) roids
55
Rx Goodpasture's
plasma exchange therapy | pulsed roids
56
Sudden onset edema, Hodgkin Lymphoma, NSAID use, tendency for thrombotic events
Minimal Change, effaced podocytes roids
57
African American, HTN, IV drugs and HIV with nephrotic sympotoms also Rx?
FSGS pred, cytotoxics, ACEI/ARB for proteinuria
58
Adenocarcinoma or other solid tumor, nephrotic syndrome, Spike and dome deposits of IgG and C3 in basement membrane also Rx?
Membranous nephropathy pred and cytotoxics
59
Long standing DM, retinopathy, nephrotic syndrome, thick GBM, Increased mesangial matrix, kimmelstiel-Wilson lesion also Rx?
Diabetic nephropathy glycemic control
60
histology of lupus nephritis
mesangial proliferation, subendothelial and or subepithelial immune complex deposits
61
Multiple myeloma or RA (chronic inflammatory disease) with apple-green birefringence on congo red stain, renal involvement, nodular glomerulosclerosis also Rx?
Renal amyloidosis pred and melphalan
62
HBV, HCV, Tram Track, double layer basement membrane, subendothelial deposits, mesangial deposits, low C3 also Rx?
Type 1 Membranoproliferative roids
63
Four types of stones
Calcium oxalate/phosphate - idiopathic hypercalciuria Struvite - staghorn, proteus, urease producers Uric Acid - RADIOLUCENT, gout, purine turnover Cystine - hexagonal crystals, + cyanide nitro test

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