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Rapid Review Flashcards

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1
Q

Increase risk of Digoxin toxicity

A

Quinidine, cimetidine, amiodarone, CCBs

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2
Q

Competition for albumin binding sites

A

Warfarin, ASA, phenytoin

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3
Q

Hemolysis in G6PD

A

Sulfonamides, INH, ASA, ibuprofen, Nitrofurantoin, primaquine, pyrimethamine, chloramphenicol

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4
Q

Gynecomastia

A 
Some Excellent Drugs Create Awesome Knocker
Spironolactone
Estrogens
Digitalis
Cimetidine
Alchohol (chronic)
Ketoconazole
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5
Q

Steven-Johnson Syndrome

A

Anticonvulsants
Sulfonamides
penicillins

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6
Q

Photosensitivity

A

Tetracycline, amiodarone, sulfonamides

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7
Q

Drug-induced SLE

A

Procainamide, hydralazine, INH, penicillamine, chlopromazine, methyldopa, quinidine

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8
Q

Rx for anticholinesterases/organophosphate OD

A

Atropine, pralidoxime

presents with SLUDGE

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9
Q

Rx anticholinergic OD

A

Physostigmine

Red as a beat, dry as a bone, mad as a hatter

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10
Q

Betablocker OD Rx

A

glucagon

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11
Q

barbiturate OD Rx

A

urine alkalinization, dialysis, supportive

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12
Q

Benzos OD Rx

A

flumazenil

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13
Q

Black widow bite Rx

A

Ca gluconate, methocarbamol

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14
Q

Cyanide OD Rx

A

hydroxycobalamin, amyl nitrate, sodium nitrate, sodium thiosulfate

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15
Q

Arsenic Rx

A

succimer, dimercaprol (penicillamine)

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16
Q

Copper Rx

A

Penicillamine

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17
Q

Digitalis OD

A

normalize K, anti-dig Fab, avoid giving Ca, Mg, or lidocaine

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18
Q

Salicylate OD Rx

A

Urine alk, dialysis, charcoal

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19
Q

tPA, streptokinase Rx

A

aminocaproic acid

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20
Q

Amantadine SE

A

Ataxia, Livedo reticularis

dopamine agonist

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21
Q

Aminoglycosides SE

A

ototox, nephrotox (acute tubular necrosis)

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22
Q

Amiodarone SE

A

Acute: AV block, hypotension, brady
Chronic: pulm fibro, bluish discoloration, arrhythmia, hypo/hyperthyroid, corneal deposits

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23
Q

Azoles SE

fluconazole

A

Inhibition of P-450 enzymes

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24
Q

AZT SE

A

thrombocytopenia, megaloblastic anemia

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25
carbamazepine SE
induce p450 AGRANULOCYTOSIS liver tox
26
Chloramphenicol SE
Gray baby syndrome, aplastic anemia
27
Cisplatin SE
nephrotox, acoustic nerve damage
28
Clonidine SE
severe rebound HA and HTN
29
Clozapine SE
agranulocytosis
30
cyclophosphamide SE
hemorrhagic systitis (give MESNA) risk for bladder cancer
31
Digoxin SE
GI disturbance (nausea) Yellow vision changes Arrythmias (junctional or SVT) atrial tach with AV block
32
Doxorubicin SE
Cardiotoxicity
33
Fluoroquinolones SE
carilage damage in children, Achilles tendo rupture in adults
34
Furosemide SE
Ototox, hypoK, nephritis, gout
35
Gemfibrozil SE
myositis
36
Halothane SE
malignant hyperthermia | hepatotox
37
HCTZ SE
Hypo-K,Na,Mg | Hyper-glyc,uremia,calcemia
38
Hydralazine SE
drug induced SLE
39
INH SE
Peripheral neuropathy (give pyridozine/B6) Hepatotox, inhib p450, SZ hemolysis in G6PD
40
MAOIs (selegeline)
Hypertensive Tyramine Reaction, Serotonin Syndrome with meperidine
41
methotrexate SE
Hepatic fibrosis, pneumonitis, anemia (folate inhibition)
42
methyldopa SE
Drug induced SLE
43
Metronidazole SE
disulfiram rxn, vestibular dys, metallic taste
44
Penicillamine SE
Drug induced SLE
45
Phenytoin SE
Gingival hyperplasia, hirsutism, nystagmus, diplopia, ataxia, arrhythmia, teratogen
46
Procainamide SE
Drug-Induced SLE
47
PTU SE
agranulocytosis, aplastic anemia
48
Quinidine SE
torsades, cinchonism (HA, tinnitus), Drug-induced Lupus
49
Succinylcholine SE
malignant hyperthermia, hyper K
50
Tetracyclines SE
tooth discolor, photosens, fanconi syndrome, GI distress dont give to kids under 8
51
Valproate SE
teratogen = neural tube defect, rare fatal hepatotox
52
Vinblastine SE
severe myelosuppression
53
Vincristine SE
peripheral neuropathy, paralytic ileus
54
Vit A Def
night blindness, dry skin
55
Vit B1 (thiamine) Def
Beriberi (polyneuritis, dilated cardiomyopathy, hyigh-output CHF, edema) Wernicke-Korsakoff (gait, eye problems, confabulation)
56
Vit B2 (riboflavin) Def
Angular stomatitis, cheilosis, corneal vascularization
57
Vit B3 (niacin) Def
Pellagra DDD (diarrhea, dermatitis, dementia)
58
Vit B5 (pantothenate) Def
Dermatitis, enteritis, alopecia, adrenal insufficiency (hypotension, hyponatremia, hyperk)
59
Vit B6 (pyridoxine) Def
Convulsions, hyperirritability
60
Vit C Def
Scurvy (swollen gums, bruising, anemia, poor wound healing, curly hair?)
61
Vit E Def
Fragile RBCs --> hemolysis?
62
Vit K Def
neonatal hemorrhage, high PT and aPTT
63
Biotin Def
Dermatitis, enteritis, caused by raw egg ingestion
64
Mg deficiency
weakness, muscle cramps, tremors, choreoathetoid mvmt, hypocalcemic tetany
65
Selenium def
cardioyopathy (Keshan dz)

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