Ranolazine Flashcards Preview

CV PHARM...Antianginal > Ranolazine > Flashcards

Flashcards in Ranolazine Deck (7)
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1

what is it?

novel metabolic modulator

2

MOA

unknown
partial fatty acid oxidase inhibitor--> increases glucose oxidation--> increased O2 utilization efficiency in heart

3

Effects

No effect on HR or BP

4

Indications

chronic stable angina

in combination w/:
--amlodapine,
--BBs, or
--Nitrates

5

acute anginal attacks

will not relieve

6

Problems

Pregnancy category C

Expensive w/ only marginal benefit

7

Contraindications

use w/ cyp3A inhibitors
hepatic impairment