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Flashcards in Rate Determining Enzymes Deck (10):
1

Glycolysis

Phosphofructokinase-1

Fructose-6-Pi ---> Fructose 1,6 BisPi

Regulation: (+) F23BP, AMP
(-) ATP and Citrate

2

Gluconeogenesis


** Where does the ATP that drives gluconeogenesis come from?

Fructose 1,6 Bisphosphatase

Fructose 1,6 BPi ---> Fructose 6 Pi

(-) F 23 BP

**Oxidation of Fatty acids

3

TCA cycle

Isocitrate Dehydrogenase

Isocitrate ---> Alpha Ketoglutarate

(+) ADP
(-) NADH

4

Glycogen Synthesis

Glycogen Synthase

(-) when phosphyrolated due to ^[cAMP] and ^ [PKA]

5

Glycogenolysis

Glycogen Phosphorylase

(+) when phosphorylated due to ^[cAMP] and ^[PKA] due to glucagon and epinepherine

6

HMP Shunt (Pentose Phosphosphate Pathway)

What does this enzyme cause production of?

Glucose 6 Phosphate Dehydrogenase

G-6-P ---> Ribulose 5 Phosphate

Generates NADPH necessary to maintain reduced glutothionine

7

Fatty Acid Synthesis

Acetyl-CoA carboxylase

8

Fatty Acid Oxidation

Carnitine Acetyltransferase 1 (CAT-1)
Fatty Acyl CoA + Carnitine ---> Fatty Acyl Carnitine + CoA

(-) Malonyl CoA inhibits CAT 1 during FA synthesis to avoid a futile cycle.
(+) ^ Fatty Acid Concentration

9

Ketogenesis

HMG-CoA synthase

10

Cholesterol Synthesis

HMG CoA reductase