Rate Limiting Enzymes Flashcards

(32 cards)

1
Q

rate limiting enzyme of glycolysis

A

PFK-1

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2
Q

rate limiting enzyme of gluconeogenesis

A

fructose 1,6-bisphosphatase

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3
Q

rate limiting enzyme of TCA cycle

A

isocitrate dehydrogenase

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4
Q

rate limiting enzyme of of glycogenesis

A

glycogen synthase

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5
Q

rate limiting enzyme of glycogenolysis

A

glycogen phosphorylase

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6
Q

rate limiting enzyme of HMP shunt (pentose phosphate pathway)

A

glucose-6-phosphate dehydrogenase (G6PD)

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7
Q

rate limiting enzyme of purine synthesis

A

glutamine phosphoribosylphosphate amidotransferase (PRPP)

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8
Q

rate limiting enzyme of pyrimidine synthesis

A

CPS II

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9
Q

rate limiting enzyme of urea cycle

A

CPS I

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10
Q

rate limiting enzyme of fatty acid synthesis

A

acetyl CoA carboxylase

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11
Q

rate limiting enzyme of fatty acid oxidation

A

carnitine acyltransferase I (CAT I)

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12
Q

rate limiting enzyme of ketogenesis

A

HMG CoA synthase

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13
Q

rate limiting enzyme of cholesterol synthesis

A

HMG CoA reductase

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14
Q

what is the rate limiting enzyme of bile synthesis

A

7-alpha hydroxylase

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15
Q

what are 2 activators of PFK-1, the rate limiting enzyme of glycolysis

A

AMP
fructose 2,6-bisphosphate

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16
Q

what are 2 inhibitors of PFK-1, the rate limiting enzyme of glycolysis

17
Q

what are 2 activators of fructose 1,6-bisphosphate, the rate limiting enzyme of gluconeogenesis

18
Q

what is an activator of the isocitrate dehydrogenase, the rate limiting enzyme of the TCA cycle

19
Q

what are 2 inhibitors of isocitrate dehydrogenase, the rate limiting enzyme of the TCA cycle

20
Q

what are 3 activators of glycogen synthase, the rate limiting enzyme of glycogenesis

A

glucose 6-phosphate
insulin
cortisol

21
Q

what are 2 inhibitors of glycogen synthase, the rate limiting enzyme of glycogensis

A

epinephrine
glucagon

22
Q

what are 3 activators of glycogen phosphorylase, the rate limiting enzyme of glycogenolysis

A

epinephrine
glucagon
AMP

23
Q

what are 3 inhibitors of glycogen phosphorylase, the rate limiting enzyme of glycogenolysis

A

glucose 6 phosphate
insulin
ATP

24
Q

what activates G6PD, the rate limiting enzyme of the HMP shunt

25
what inhibits G6PD, the rate limiting enzyme of the HMP shunt
NADPH
26
what 2 molecules activate CPS II, the rate limiting enzyme of pyrimidine synthesis
ATP PRPP
27
what inhibits CPS II, the rate limiting enzyme of pyrimidine synthesis
UTP
28
what 3 molecules inhibit PRPP, the rate limiting enzyme of purine synthesis
GXP AXP IMP
29
what activates CPS I, the rate limiting enzyme of the urea cycle
NAG
30
what 2 molecules activate acetyl CoA carboxylase, the rate limiting enzyme of FA synthesis
insulin citrate
31
what molecule inhibit acetyl CoA carboxylase, the rate limiting enzyme of FA synthesis
glucagon
32
what molecule inhibits CAT I, the rate limiting enzyme of fatty acid oxidation
malonyl CoA