Rate Limiting Enzymes Flashcards Preview

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Flashcards in Rate Limiting Enzymes Deck (26):
1

Glycolysis

Phosphofructokinase-1 (PFK-1)

2

PFK-1 regulators

Pos: AMP, F26BP
Neg: ATP, citrate
GLYCOLYSIS

3

Gluconeogenesis

Fructose-1,6-bisphoshatase

4

F16BP regulators

Pos: ATP, acetyl-CoA
Neg: AMP, F26BP
GLUCONEOGENESIS

5

TCA cycle

Isocitrate dehydrogenase

6

Isocitrate dehydrogenase regulators

Pos: ADP
Neg: ATP, NADH
TCA CYCLE

7

Glycogenesis

Glycogen synthase

8

Glycogen synthase regulators

Pos: G6P, insulin, cortisol
Neg: epinephrine, glucagon
GLYCOGENESIS

9

Glycogenolysis

Glycogen phosphorylase

10

Glycogen phosphorylase regulators

Pos: epinephrine, glucagon, AMP
Neg: G6P, insulin, ATP
GLYCOGENOLYSIS

11

HMP shunt/PPP

Glucose-6-phosphate dehydrogenase (G6PD)

12

G6PD regulators

Pos: NADP+
Neg: NADPH
HMP SHUNT/PPP

13

De novo pyrimidine synthesis

Carbamoyl phosphate synthetase II

14

Carbamoyl phosphate synthetase II regulators

None
DE NOVO PYRIMIDINE SYNTHESIS

15

De novo purine synthesis

Glutamine-phosphoribosylpyrophosphate (PRPP) aminotransferase

16

PRPP aminotransferase regulators

Neg: AMP, inosine monophosphate, GMP
DE NOVO PURINE SYNTHESIS

17

Urea cycle

Carbamoyl phosphate synthetase I

18

Carbamoyl phosphate synthetase I regulators

Pos: N-acetylglutamate
UREA CYCLE

19

FA synthesis

Acetyl-CoA carboxylase (ACC)

20

Acetyl-CoA carboxylase regulators

Pos: insulin, citrate
Neg: glucagon, palmitoyl-CoA
FA SYNTHESIS

21

FA oxidation

Carnitine acyltransferase I

22

Carnitine acyltransferase I regulators

Neg: malonyl-CoA
FATTY ACID OXIDATION

23

Ketogenesis

HMG-CoA synthase

24

HMG-CoA synthase regulators

None
KETOGENESIS

25

Cholesterol synthesis

HMG-CoA reductase

26

HMG-CoA reductase regulators

Pos: insulin, thyroxine
Neg: glucagon, cholesterol
CHOLESTEROL SYNTHESIS