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MTAP-3-Hematology > RBC > Flashcards

RBC Flashcards

(61 cards)

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1
Q

Insufficient erythropoisis refers to the production of _____ RBC ______

A

Low number; RBC precursors

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2
Q

Term referring to the total mass of RBC in the blood and marrow

A

ERYTHRON

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3
Q

What type of abnormal eythropoeisis do thalassemia and sideroblastic anemia, vit b12/folate deficiency produce?

A

INEFFECTIVE erythropoeisis

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4
Q

3 conditions that result in the decrease in the production of RBC count (insufficient erythropoeisis)

A
  1. IDA
  2. RENAL DISEASE
  3. ACUTE LEUKEMIA
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5
Q

Colony Forming Unit- Erythroid is a type of what RBC cell

A

Progenitor = morphologically UNIDENTIFIABLE

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6
Q

Classical marker of HSC

A

CD 34

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7
Q

Earliest marker of erythroid differentiation is ______

It also functions as ______

A
  1. CD 71

2. Aka TRANSFERRIN RECEPTOR

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8
Q

The major mechanism of EPO that increases RBC mass is via

A

Prevention of apoptosis

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9
Q

Primary cell source of EPO is

A

Peritubular interstitial cell

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10
Q

Progenitor cells such as CFU-E is target by what hormone?

A

EPO

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11
Q

3 mechanisms why EPO can increase RBC count

A
  1. Decrease maturation time
  2. Early reticulocyte release
  3. Apoptosic Rescue
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12
Q

This is a non-dialyzable and thermos table hormone

A

EPO

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13
Q

What is labelled to RBC in order to determine survival time? This is reported in ___

A
  1. Chromium-51

2. 51Cr half survival time

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14
Q

What is the normal RBC survival time range

A

28-38 days

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15
Q

What hormone has an application in enabling autologous predonation

A

EPO

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16
Q

Hormone produced by the testes is ______

Action: ______

Affects what organ:______

A
  1. Testosterone
  2. Indirect stimulation of EPO
  3. Signals kidney to produce EPO
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17
Q

Which 2 hormones directly stimulate erythropoeisis. Which organs secrete/produce them?

A

GH (pituitary gland)

Prolactin (Ant. Pituitary gland)

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18
Q

Main reason why males have higher RBC mass than females

A

Hormones. Females have ESTROGEN = inhibits EPO (INDIRECTLY)

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19
Q

Estrogen mechanism of action

A

Inhibits EPO production by suppressing its production in kidney

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20
Q

Which hormone secreted by the pituitary gland that affects the BM

A

GH

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21
Q

Blood doping may result to what condition/s

A

Arterial and venous thrombosis

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22
Q

In order for HIV-anemic patients to use Zidovudine (AZT), what is needed?

A

EPO

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23
Q

One BFU-E matures, how long does it stay in the bone marrow being a recognizable precursor

A

6 days

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24
Q

How long does BFU-E mature?

A

18-21 days

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25
Examples of supravital stains
1. New methylene blue | 2. Brilliant cresyl blue
26
Other names of EARLY NORMOBLAST
1. Basophilic normoblast/ erythroblast | 2. Prorubricyte
27
Metarubricyte is also known as
Orthochromatic normoblast/ erythroblast
28
When reticulocytes are Wright-stained, they are now termed as:
1. Polychromatophilic erythrocytes | 2. Diffusely basophilic erythrocytes
29
Which stage is the pink acidophilic stain visible on red cells
Rubricyte/ polychromatic normoblast
30
How many nucleolus can be seen in prorubricytes/ basophilic normoblasts
None to 1
31
It is in this stage that nuclear membrane becomes thick
Rubricyte/ polychromatic
32
Most helpful criteria to distinguish rubriblast from prorubricyte
PRORUBRICYTE: 1. Coarser chromatin 2. No nucleoli
33
Which RBC precursor is often confused with lymphocytes?
Rubricyte
34
Blueness/ basophilic intensity correlates with the _____
Amount of rRNA
35
Last stage capable of dividing
rubricyte
36
1st stage that Hb is produced
Prorubricyte
37
Earliest recognizable precursor ____ N:C ratio is ____
1. Rubriblast | 2. (8:1)
38
Checkered nucleus is a helpful distinguishing criteria of which precursor. This helps the RMT from confusing it from what cell
Rubricyte has checker nucleus; gray cytoplasm to differentiate it from LYMPHOCYTE
39
Appearance of lymphocyte to differentiate it from orthochromatic normoblast
Nucleus - crushed velvet Cytoplasm - sky blue or robin egg
40
Which stage you begin to notice acidophilia/ pink color in cytoplasm
Polychromatophilic/ Rubricyte
41
Which RBC precursor cytoplasm has same color with a mature RBC
Late normoblast/ orthochromatic/ Metarubricyte
42
3 alternative name of Metarubricyte
1. Acidophilic 2. NRBC 3. Pyknotic
43
The presence of _____may indicate that a patient has no spleen
Howell-Jolly bodies
44
Last stage with a nucleoli
Prorubricyte/ basophilic/early
45
Last stage with a nucleus
Metarubricyte/ orthochromatic/ late
46
_____ is an enveloped extruded nucleus
Pyrenocyte
47
Small DNA fragments left in a cell is called ____
Howell jolly body
48
A dense mass of degenerated chromatin is referred as
Pyknotic
49
Which part of ACIDOPHILIC erythroblast is seen as color salmon pink?
Cytoplasm
50
Before becoming a mature RBC, reticulocytes spend how many days in the peripheral blood
1 day
51
Reticulocytes spend ______ days in the bone marrow before maturing
2 to 3 days
52
Severe conditions such as hemolytic anemia cause the appearance of what type of reticulocytes??
Stress reticulocyte a.k.a MACROreticulocyte
53
Polychromatophilic macrocytes is also known as ______; this is seen in what cases?
1. SHIFT retics | 2. Seen in increased RBC production
54
What 3 components are still present in reticulocyte that enable the production of hemoglobin and aerobic metabolism
RNA, Golgi body, mitochondria remnants
55
1st stage of Hemoglobinization
Prorubricyte / basophilic / early
56
Last stage of hemoglobinization
Reticulocyte
57
Production of ____ WBC & ___ PLT = ____ RBC ____RBC, respectively
1 WBC = 600 RBC | 1 PLT = 15 RBC
58
How many Metarubricyte is made from 1 rubricyte?
2
59
1 basophilic normoblast can produce ______
1 prorubricyte = 4 rubricyte
60
1 rubriblast can produce _____
2 prorubricyte
61
Color of cytoplasm in reticulocyte
Polychromatophilic since there are still small amounts of RNA left

MTAP-3-Hematology (4 decks)

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