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HEMATOLOGY 1 > RBC PRODUCTION AND DESTRUCTION > Flashcards

RBC PRODUCTION AND DESTRUCTION Flashcards

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1
Q

factors that will induce it to mature in such a way that it will eventually lead in the production of RBC.

A

chemokines or cytokines

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2
Q

what is the goal of hematopoiesis

A

combat/alleviate any problems that the body experiences

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3
Q

erythroid progenitor cells that the rbc develop in the bone marrow

A

burst-forming unit-erythroid (BFU-E)
colony-forming unit-erythroid (CFU-E).

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4
Q

youngest to oldest precursor

A

pronormoblast
basophilic normoblast
polychromatic normoblast
orthochromic normoblast
polychromatic erythrocyte or reticulocyte.

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5
Q

what do you call the old erythroid

A

polychromatic erythrocyte or reticulocyte stage

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6
Q

what color reflects abundant ribosomal RNA

A

blue

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7
Q

what color reflects when hemoglobin accumulates &
the RNA is degraded.

A

salmon pink

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8
Q

specified or locked in in a specific
lineage

A

Totipotential

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9
Q

immature rbcs will undergo

A

mitosis

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10
Q

main function of rbc

A

carry hemoglobin to (?) path which are high

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11
Q

purpose of hemoglobin

A

carry oxygen & release oxygen to tissues

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12
Q

Goal of precursors

A

gaining of its function or maturation.

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13
Q

they’re the ones in charge stockpiling the hemoglobin while developing

A

precursor

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14
Q

t/f: The more immature the cell is, the more larger the nucleus

A

true

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15
Q

Hemoglobin has a protein component your globin & heme component, combination of

A

protoporphyrin 9
iron

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16
Q
A
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17
Q

opposite of active chromatin/ clumped chromatin

A

Heterochromatin

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18
Q

is just a string or thread and spindle is your chromatin

A

DNA

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19
Q

building up mechanism, because the nucleus itself isn’t the one making the protein/hemoglobin

A

Proerythroblast

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19
Q

The one making hemoglobin or globin portion

A

ribosome

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19
Q

signify protein production

A

Large nucleus & large component of euchromatin

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19
Q

t/f: That unwound DNA is your heterochromatin

A

false

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20
Q

excluded nucleus

A

Pyrenocyte

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20
Q

In this early phase, there are still a lot of mRNA production wala pa kaayo ribosoemes

A

Proerythroblast

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21
consumable cells
RBC
22
How can you say the cell is already a pronormoblast from your colony forming units?
There is production of organelles that will lead to hemoglobin production
23
nc ratio of pronormoblast
8:1
24
what is the color of cytoplasm of pronormoblast and why?
dark blue due to concentration of ribosomes & RNA.
25
The pronormoblast undergoes mitosis & gives rise to
2 daughter pronormoblasts
26
begins to accumulate the components necessary for hemoglobin production.
pronormoblast
27
globin production begins
pronormoblast
28
nucleus will stain what color and why
blue because nucleus is acidic
29
basic stain gives what color
blue
30
acidic stain will give what color
red
31
In the context of your cytoplasm, why is it dark blue?
There are a lot euchromatin and mRNA
32
is the most immature phase
pronormoblast
33
The chromatin begins to condense, revealing clumps along the periphery of the nuclear membrane and a few in the interior
BASOPHILIC NORMOBLAST
34
nc ratio of basophilic normoblast
6:1
35
chromatin color of basophilic normoblast
deep purple-red
36
chiefly for hemoglobin production
mRNA
37
N:C ratio of polychromatic normoblast
4:1
38
Notably, no nucleoli are present.
polychromatic normoblast
39
color of polychromatic normoblast
pink
40
why is the polychromatic normoblast pink
decreasing amounts of RNA.
41
This is the last stage in which the cell is capable of undergoing mitosis,
polychromatic normoblast
42
is a protein in the human body and it is more basic because of the amount of amino acids.
Hemoglobin
43
nc ratio of orthochromic normoblast
1:2
43
reflects nearly complete hemoglobin production.
orthochromic normoblast
44
color of orthochromic normoblast
salmon pink
44
not capable of division because of the condensation of the chromatin.
orthochromic normoblast
45
Late in the stage, the nucleus is ejected from the cell
orthochromic normoblast
46
there is no nucleus.
polychromatic erythrocyte
47
how long does the polychromatic erythrocyte resides in the bone marrow
1 to 2 days
47
the cell is the same color as a mature RBC
salmon pink, polychromatic erythrocyte
47
how long does the polychromatic erythrocyte resides in the bone marrow
1 day before reaching maturity.
48
digests the ribosomes.
Endoribonuclease
48
We will only call it reticulocyte when we stain it with
supravital stain
49
completes production of hemoglobin from a small amount of residual messenger RNA using the remaining ribosomes
polychromatic erythrocyte
50
what cells do supravital stain stains?
live cells
51
there are still reticulum left which is composed of RNA
reticulocyte
52
stain used in erythrocyte
Wright-stained blood film
53
life span of rbc
120 days
54
Aging of rbc leads to their removal by what organ
spleen
55
spherical rbc/circle shape
hard time transferring your gasses
56
57
donut shape rbc
gas transfer is faster
58
the ability to traverse through tight curvices, tight blood vessels
Deformability
59
how many days for the BFU-E to mature to an RBC
18 to 21
60
how many days are spent as identifiable precursors in the bone marrow.
6 days
61
what organ who produces EPO
kidney
62
a hormone that stimulates production and survival of red blood cells
Erythropoietin
63
transmembrane receptor that stimulate apoptosis
Fas receptor
64
cells give iron to the red blood cells.
nurse cells
65
red blood cell precursor get iron is from, a soluble transport type of your iron
transferrin
66
primary hormone that stimulates the production of erythrocytes,
EPO
67
the ligand, is expressed by older erythroid precursors.
FasL
68
increases hepcidin. Meaning, there is an increase in iron absorption.
Erythroferrone
69
rescues CFU-E cells from apoptosis
EPO
70
cannot regenerate catabolized enzymes because they lack a nucleus.
Aged RBCs
71
accounts for most normal RBC deaths.
macrophage-mediated hemolysis
71
results when mechanical factors rupture the cell membrane while the cell is in the peripheral circulation.
intravascular hemolysis
71
marker for phagocytosis
Phosphatidylserine
72
This pathway accounts for a minorcomponent of normal destruction of RBCs
intravascular hemolysis

HEMATOLOGY 1 (6 decks)

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