Receptors Flashcards
(17 cards)
Nicotinic N
Type
Location
Response
Nicotinic N
Type cholinergic
Location Adrenal medulla
postganglionic neuron
Response Release of epi from adrenal medulla
Postganglionic neural transmission
Nicotinic M
Type
Location
Response
Type cholinergic
Location Neuromuscular junction
Response Contraction of skeletal muscle
Preganglionic Neurotransmitter
and found in synaptic cleft in PSNS; SNS and released by motor neuron of the SoNS?
Receptor found in synaptic cleft before postganglinic neuron of the PaSNS; SNS and adrenal medulla?
ACh
Nn = Nicotinic N
Transmitter and receptor after postganglionic neuron AKA neuroeffector transmitter in the PaSNS?
ACh; NicotinicN
Transmitter and receptor after postganglionic neuron AKA neuroeffector transmitter in the SNS (except sweat glands)?
NorEpi (NE); a and b adrenergic
Transmitter and receptor after postganglionic neuron AKA neuroeffector transmitter in the sweat glands (SNS)?
ACh; Muscarinc
Neuroeffector Transmitter and receptor after stimulation of the adrenal medulla in the SNS?
Epi; a, b
Transmitter and receptor after motor neuron in the SoNS?
ACh; Nicotinic M
Receptor Subtype alpha 1
Tissues
Response
Receptor Subtype alpha 1 postsynaptically
vascular smooth muscle contract
GU smooth muscle contract
GI smooth muscle relax
heart increase inotropy & excitability
Liver glyconeolysis & gluconeogenesis
Receptor Subtype alpha 2
Tissues
Response
Receptor Subtype alpha 2
Pancreatic B cell inhibit insulin secretion
Platelets aggregation
Nerve Decrease NE release
Vascular smooth muscle contract
Receptor Subtype Beta 1
Tissues
Response
Receptor Subtype Beta 1
TISSUE
Heart inc. chronotrophy & inotrophy
Heart inc. AV node conduction velocity
Renal juxtaglomerular cells increase renin secretion
Receptor Subtype Beta 2
Tissues
Response
Receptor Subtype Beta 2
TISSUE
Smooth muscle Relaxation of uterine & Bronchial
liver Glycogenolysis & Gluconeogenesis
skeletal muscle Glycogenolysis & K+ uptake
Receptor Subtype Beta 3
Tissues
Adipose lipolysis
Alpha 1 receptor effect on vessels eye bladder sphincter blood pressure
vessels vasoconstriction & inc. BP
increase peripheral resistance
eye mydriasis
bladder internal sphincter closure
Alpha 2 receptor is found?
action?
Presynaptic junction
pancreatic B cells - insulin inhibition
autonomic inhibition - inhibit NE release
inhibit ACh release
Beta 2 agonist action bladder detrussor eye ciliar muscle GI tract Liver Smooth muscle
bladder detrussor relax
eye ciliar muscle relax
GI tract decrease motility
Liver Smooth muscle incr. glucose metabolism/lipolysis
Vascular SM relax
Alpha Adrenoceptors affinity
Beta adrenoreceptors
epi, norepi, isproterenol
isoproterenol, Epi, NE
