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Flashcards in Receptors Deck (18)
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1

affinity =

potency

2

tendency to activate a receptor =

efficacy

3

antagonists and efficacy =

antagonists have 0 efficacy (when neutral)

4

a partial agonist and efficacy

partial agonists have an intermediate level of efficacy.so even at 100% binding to receptors, they can only produce an intermediate effect

5

efficacy describes

the tendency of the drug-receptor complex to adopt the active AR* rather than the resting AR state.

A drug with 0 efficacy has no tendency to cause receptor activation and causes no tissue response.

6

muscarinic actylcholine receptors
adrenoreceptors

GPCR

7

nicotinic acetylcholine receptor
GABA

Ligand gated

8

fast transmission is associated with

ligand gated channels

9

cys-loop receptor subunits

five subunits !!

10

inotropic glutmate receptor subunits

four !!

11

Examples of cys-loop receptors

nicotinic acteylcholine receptor, glycine receptor, 5ht-3receptor

12

Examples of inotropic glutamate receptors

AMPA receptor
NMDA receptor
kaintate receptor

13

gating on a cys-loop receptor

the second transmembrane domain of the subunit generally obstructs the pore

14

cys-loop receptor has two

alpha sub units

15

Drugs that act on cys-loop receptors

Nicotine/Chantix (nACH)
Ambien, barbiturates, ETOH -> GABAa

16

drugs that act on inotropic glutamate receptors

Ketamine (NMDA)
Aniracetam (AMPA)

17

Special properties that underly NMDA receptor involvement in LTP

VG magnesium block, permeability to Ca2+

18

most common target for pharmacetuicals

GPCR